Cells  

Susana Brun, Nicolas Schall, Hélène Jeltsch-David, Jérôme de Sèze and Sylviane Muller

The rat sciatic nerve has attracted widespread attention as an excellent model system for studying autophagy alterations in peripheral neuropathies. In our laboratory, we have developed an original rat model, which we used currently in routine novel drug ... see more

Andrea Duechting, Anna Przybyla, Stefanie Kuerten and Paul V. Lehmann

During immune responses, different classes of T cells arise: Th1, Th2, and Th17. Mobilizing the right class plays a critical role in successful host defense and therefore defining the ratios of Th1/Th2/Th17 cells within the antigen-specific T cell reperto... see more

Eleni Nikolakaki, Ilias Mylonis and Thomas Giannakouros

Yanfang Chen, Vincent Scarcelli and Renaud Legouis

Macroautophagy (hereafter referred to as autophagy) is an intracellular degradative process, well conserved among eukaryotes. By engulfing cytoplasmic constituents into the autophagosome for degradation, this process is involved in the maintenance of cell... see more

Bor Luen Tang

The proneural factor Achaete-scute complex-like 1 (Ascl1/Mash1) acts as a pioneering transcription factor that initializes neuronal reprogramming. It drives neural progenitors and non-neuronal cells to exit the cell cycle, and promotes neuronal differenti... see more

Irene Benito-Cuesta, Héctor Diez, Lara Ordoñez and Francisco Wandosell

Autophagy is a complex process that controls the transport of cytoplasmic components into lysosomes for degradation. This highly conserved proteolytic system involves dynamic and complex processes, using similar molecular elements and machinery from yeast... see more

Natalia Jiménez-Moreno, Petros Stathakos, Maeve A. Caldwell and Jon D. Lane

Human induced pluripotent stem cells (hiPSCs) are invaluable tools for research into the causes of diverse human diseases, and have enormous potential in the emerging field of regenerative medicine. Our ability to reprogramme patient cells to become hiPSC... see more

Raffaela Torggler, Daniel Papinski and Claudine Kraft

Autophagy is an intracellular process responsible for the degradation and recycling of cytoplasmic components. It selectively removes harmful cellular material and enables the cell to survive starvation by mobilizing nutrients via the bulk degradation of ... see more

Péter Lorincz, Caroline Mauvezin and Gábor Juhász

Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation of cellular components within lysosomes. In recent decades, several model systems were utilized to dissect the molecular machinery of autophagy and to identify th... see more

Benan John Mathai, Annemarie H. Meijer and Anne Simonsen

Autophagy is an evolutionarily conserved catabolic process which allows lysosomal degradation of complex cytoplasmic components into basic biomolecules that are recycled for further cellular use. Autophagy is critical for cellular homeostasis and for degr... see more

Idil Orhon and Fulvio Reggiori

The vast number of implications of autophagy in multiple areas of life sciences and medicine has attracted the interest of numerous scientists that aim to unveil the role of this process in specific physiological and pathological contexts. Cell cultures a... see more

Eline E. Van Haaften, Carlijn V. C. Bouten and Nicholas A. Kurniawan

The paradigm of regenerative medicine has recently shifted from in vitro to in situ tissue engineering: implanting a cell-free, biodegradable, off-the-shelf available scaffold and inducing the development of functional tissue by utilizing the regenerative... see more

Eunice Domínguez-Martín, Elena Cardenal-Muñoz, Jason S. King, Thierry Soldati, Roberto Coria and Ricardo Escalante

Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic intracell... see more

Wim Martinet, Lynn Roth and Guido R. Y. De Meyer

Autophagy is a highly conserved lysosomal degradation pathway with major impact on diverse human pathologies. Despite the development of different methodologies to detect autophagy both in vitro and in vivo, monitoring autophagy in tissue via immunohistoc... see more

Fengjuan Wang, Baihui Li, Nicolas Schall, Maud Wilhelm and Sylviane Muller

Autophagy is a tightly regulated mechanism that allows cells to renew themselves through the lysosomal degradation of proteins, which are misfolded or produced in excess, and of damaged organelles. In the context of immunity, recent research has specially... see more