Cells  

Flaminia Chellini, Alessia Tani, Larissa Vallone, Daniele Nosi, Paola Pavan, Franco Bambi, Sandra Zecchi Orlandini and Chiara Sassoli

The antifibrotic potential of platelet-rich plasma (PRP) is controversial. This study examined the effects of PRP on in vitro transforming growth factor (TGF)-β1-induced differentiation of fibroblasts into myofibroblasts, the main drivers of fibrosis... see more

Maryam Oroujeni, Javad Garousi, Ken G. Andersson, John Löfblom, Bogdan Mitran, Anna Orlova and Vladimir Tolmachev

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Ruhel Ahmad, Vincenza Sportelli, Michael Ziller, Dietmar Spengler and Anke Hoffmann

Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in thinking, perception, emotion, language, sense of self, and behavior. Epidemiological evidence suggests that subtle perturbations in early neurodevelopment increa... see more

Joel K. Durand, Qing Zhang and Albert S. Baldwin

While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of t... see more

Michaela Dostalova Merkerova, Hana Remesova, Zdenek Krejcik, Nikoleta Loudova, Andrea Hrustincova, Katarina Szikszai, Jaroslav Cermak, Anna Jonasova and Monika Belickova

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Marie Bobowski-Gerard, Francesco Paolo Zummo, Bart Staels, Philippe Lefebvre and Jérôme Eeckhoute

Hepatic stellate cells (HSCs) serve as the main body storage compartment for vitamin A through retinyl ester (RE)-filled lipid droplets (LDs). Upon liver injury, HSCs adopt a myofibroblastic phenotype characterized by an elevated expression of extracellul... see more

Martin Kräter, Jiranuwat Sapudom, Nicole Christin Bilz, Tilo Pompe, Jochen Guck and Claudia Claus

The cellular cytoskeleton is central for key cellular functions, and as such is a marker for diseased and infected cell states. Here we analyzed infection with rubella virus (RV) strains with respect to phenotypes in cellular mechanical properties, cell m... see more

Yue Wang, Xiaochen Meng and Lianqing Zhu

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Duy N. Do, Pier-Luc Dudemaine, Bridget E. Fomenky and Eveline M. Ibeagha-Awemu

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Julia Concetti and Caroline L. Wilson

Current evidence strongly suggests that aberrant activation of the NF-κB signalling pathway is associated with carcinogenesis. A number of key cellular processes are governed by the effectors of this pathway, including immune responses and apoptosis... see more

Erik W. Martin and Myong-Hee Sung

Technological advances are continually improving our ability to obtain more accurate views about the inner workings of biological systems. One such rapidly evolving area is single cell biology, and in particular gene expression and its regulation by trans... see more

Estefania Carrasco-Garcia, Isabel Martinez-Lacaci, Leticia Mayor-López, Elena Tristante, Mar Carballo-Santana, Pilar García-Morales, Maria Paz Ventero Martin, Maria Fuentes-Baile, Álvaro Rodriguez-Lescure and Miguel Saceda

Glioblastomas are highly resistant to radiation and chemotherapy. Currently, there are no effective therapies for this type of tumor. Signaling mechanisms initiated by PDGFR and IGF-1R are important in glioblastoma, and inhibition of the signal transducti... see more

Mohamed A. Elmonem, Sante Princiero Berlingerio, Lambertus P. Van den Heuvel, Peter A. De Witte, Martin Lowe and Elena N. Levtchenko

The structural and functional similarity of the larval zebrafish pronephros to the human nephron, together with the recent development of easier and more precise techniques to manipulate the zebrafish genome have motivated many researchers to model human ... see more

Jasmina Makarevic, Jochen Rutz, Eva Juengel, Sebastian Maxeiner, Jens Mani, Stefan Vallo, Igor Tsaur, Frederik Roos, Felix K.-H. Chun and Roman A. Blaheta

This study was designed to investigate whether epigenetic modulation by histone deacetylase (HDAC) inhibition might circumvent resistance towards the mechanistic target of rapamycin (mTOR) inhibitor temsirolimus in a prostate cancer cell model. Parental (... see more

Natsuko Miura and Mitsuyoshi Ueda

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Andrea Aparecida De Aro, Giane Daniela Carneiro, Luis Felipe R. Teodoro, Fernanda Cristina Da Veiga, Danilo Lopes Ferrucci, Gustavo Ferreira Simões, Priscyla Waleska Simões, Lúcia Elvira Alvares, Alexandre Leite R. De Oliveira, Cristina Pontes Vicente, Caio Perez Gomes, João Bosco Pesquero, Marcelo Augusto M. Esquisatto, Benedicto De Campos Vidal and Edson Rosa Pimentel

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Robin Lüling, Harald John, Thomas Gudermann, Horst Thiermann, Harald Mückter, Tanja Popp and Dirk Steinritz

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Bakhtiar Yamini

Although glioblastoma (GBM) has always been recognized as a heterogeneous tumor, the advent of largescale molecular analysis has enabled robust categorization of this malignancy into several specific subgroups. Among the subtypes designated by expression ... see more

Noritoshi Shamoto, Keishi Narita, Tomohiro Kubo, Toshiyuki Oda and Sen Takeda

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Avat Shekoofa and Thomas R. Sinclair

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Jens Staal and Rudi Beyaert

Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and benign. Due to its high prevalence, it is, however, still the second most common cause of death by cancer in men in the West. The higher prevalence of prostate cancer... see more

Marisa M. L. Tillery, Caitlyn Blake-Hedges, Yiming Zheng, Rebecca A. Buchwalter and Timothy L. Megraw

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Xiaoxu Li, Salman Ahmad, Cun Guo, Jing Yu, Songxiao Cao, Xiaoming Gao, Wei Li, Hong Li and Yongfeng Guo

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Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Tara M. Mahvelati, Abdelaziz Amrani and Denis Gris

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Jianlin Wang, Zhaoping Qiu and Yadi Wu

Histone post-translational modifications influence many fundamental cellular events by regulating chromatin structure and gene transcriptional activity. These modifications are highly dynamic and tightly controlled, with many enzymes devoted to the additi... see more

Bessi Qorri, Regina-Veronicka Kalaydina, Aleksandra Velickovic, Yekaterina Kaplya, Alexandria Decarlo and Myron R. Szewczuk

The extracellular matrix (ECM) is a highly dynamic noncellular structure that is crucial for maintaining tissue architecture and homeostasis. The dynamic nature of the ECM undergoes constant remodeling in response to stressors, tissue needs, and biochemic... see more

Seulah Lee, Seul Lee, Hyun-Soo Roh, Seong-Soo Song, Rhim Ryoo, Changhyun Pang, Kwan-Hyuck Baek and Ki Hyun Kim

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Jack A. Prescott and Simon J. Cook

Deregulated NF-κB signalling is implicated in the pathogenesis of numerous human inflammatory disorders and malignancies. Consequently, the NF-κB pathway has attracted attention as an attractive therapeutic target for drug discovery. As the pr... see more

Camilla Paoletti, Carla Divieto and Valeria Chiono

The irreversible loss of functional cardiomyocytes (CMs) after myocardial infarction (MI) represents one major barrier to heart regeneration and functional recovery. The combination of different cell sources and different biomaterials have been investigat... see more