Cells  

Petros Batsios, Xiang Ren, Otto Baumann, Denis A. Larochelle and Ralph Gräf

The nuclear envelope (NE) consists of the outer and inner nuclear membrane (INM), whereby the latter is bound to the nuclear lamina. Src1 is a Dictyostelium homologue of the helix-extension-helix family of proteins, which also includes the human lamin-bin... see more

Frank Christian, Emma L. Smith and Ruaidhrí J. Carmody

The NF-?B transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-?B regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proli... see more

María Milagros López de Armentia, Celina Amaya and María Isabel Colombo

Autophagy is an intracellular process that comprises degradation of damaged organelles, protein aggregates and intracellular pathogens, having an important role in controlling the fate of invading microorganisms. Intracellular pathogens are internalized b... see more

Laura D’Ignazio and Sonia Rocha

As Nuclear Factor-?B (NF-?B) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-?B becomes activated in hypoxia is still not completel... see more

Doranda Perdomo, Mélanie Bonhivers and Derrick R. Robinson

Sub-species of Trypanosoma brucei are the causal agents of human African sleeping sickness and Nagana in domesticated livestock. These pathogens have developed an organelle-like compartment called the flagellar pocket (FP). The FP carries out endo- and ex... see more

Noam Zuela and Yosef Gruenbaum

Matefin/SUN-1 is an evolutionary conserved C. elegans inner nuclear membrane SUN-domain protein. By creating a bridge with the KASH-domain protein ZYG-12, it connects the nucleus to cytoplasmic filaments and organelles. Matefin/SUN-1 is expressed in the g... see more

Beyenech Binotti, Reinhard Jahn and John Jia En Chua

Presynaptic neurotransmitter release is dominated by the synaptic vesicle (SV) cycle and entails the biogenesis, fusion, recycling, reformation or turnover of synaptic vesicles—a process involving bulk movement of membrane and proteins. As key mediators o... see more

Jacob Keeling, Leonidas Tsiokas and Dipak Maskey

Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility, and... see more

Cells Editorial Office

Irina Vlasova-St. Louis and Paul R. Bohjanen

In response to environmental signals, kinases phosphorylate numerous proteins, including RNA-binding proteins such as the AU-rich element (ARE) binding proteins, and the GU-rich element (GRE) binding proteins. Posttranslational modifications of these prot... see more

Marie Trudel, Qin Yao and Feng Qian

Polycystin-1 (PC1) plays an essential role in renal tubular morphogenesis, and PC1 dysfunction causes human autosomal dominant polycystic kidney disease. A fundamental characteristic of PC1 is post-translational modification via cleavage at the juxtamembr... see more

Frank Entschladen, Dane A. Thyssen and David W. Drell

Most patients that die from cancer do not die due to the primary tumor but due to the development of metastases. However, there is currently still no drug on the market that specifically addresses and inhibits metastasis formation. This lack was, in the p... see more

Bor Luen Tang

The evolutionarily-conserved mitochondrial Rho (MIRO) small GTPase is a Ras superfamily member with three unique features. It has two GTPase domains instead of the one found in other small GTPases, and it also has two EF hand calcium binding domains, whic... see more