Cells  

Stéphane Demine, Sébastien Michel, Kayleen Vannuvel, Anaïs Wanet, Patricia Renard and Thierry Arnould

Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstra... see more

Marika Nordberg, Pia Forsberg, Dag Nyman, Barbro H. Skogman, Clara Nyberg, Jan Ernerudh, Ingvar Eliasson and Christina Ekerfelt

The aim of this prospective study was to investigate the diagnostic performance of Borrelia (Bb)-induced interferon (IFN)-? secretion detected by ELISPOT modified to be feasible for clinical laboratories as a supplementary test to the laboratory diagnosis... see more

Maria Faresjö

In order to provide better therapy we strive to increase our knowledge of how the immune system behaves and communicates in common pediatric immunological diseases, such as type 1 diabetes, allergic and celiac diseases. However, when dealing with pediatri... see more

Donald D. Anthony, Kimberly A. Milkovich, Wenji Zhang, Benigno Rodriguez, Nicole L. Yonkers, Magdalena Tary-Lehmann and Paul V. Lehmann

Chronic allograft rejection is in part mediated by host T cells that recognize allogeneic antigens on transplanted tissue. One factor that determines the outcome of a T cell response is clonal size, while another is the effector quality. Studies of alloim... see more

Anatoli M. Malyguine, Susan Strobl, Kimberly Dunham, Michael R. Shurin and Thomas J. Sayers

The profiling and monitoring of immune responses are key elements in the evaluation of the efficacy and development of new biotherapies, and a number of assays have been introduced for analyzing various immune parameters before, during, and after immunoth... see more

Jennifer R. Zitzner and Anat R. Tambur

Immunologic risk in kidney transplantation is typically minimized by avoiding, or at least limiting, the potential of donor specific humoral responses by testing for the presence of donor-specific antibodies (DSA). Additionally, selecting donor and recipi... see more

Camilla Tincati, Amedeo J. Cappione III and Jennifer E. Snyder-Cappione

Mycobacterium tuberculosis (MTB) is a global heath epidemic, its threat amplified by HIV infection and the emergence of multidrug-resistant tuberculosis (MDR-TB). Interferon (IFN)-gamma release assays (IGRAs) have improved the accuracy of detection of MTB... see more

Kazuhisa Hasui, Taku Nagai, Jia Wang, Xinshan Jia, Katsuyuki Aozasa, Shuji Izumo, Yoshifumi Kawano, Takuro Kanekura, Yoshito Eizuru and Takami Matsuyama

Immunohistochemistry (IHC) for detecting key signal molecules involved in programmed cell death (PCD) in archival human pathology specimens is fairly well established. Detection of cleaved caspase-3 in lymphocytes in rheumatoid arthritis (RA) and gastric ... see more

Masahiro Hirayama, Eiichi Azuma and Yoshihiro Komada

Acute graft-versus-host disease (aGVHD) remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Infections may coexist and in certain circumstances aggravate aGVHD. It was described that type 1 as w... see more

Stine Kiaer Larsen, Morten Hansen, Inge Marie Svane, Per Thor Straten and Mads Hald Andersen

Tobias M. Nowacki, Dominik Bettenworth, Matthias Ross, Jan Heidemann, Paul V. Lehmann and Andreas Lügering

The role of cytomegalovirus (CMV) infection in the pathogenesis and exacerbation of Inflammatory Bowel Disease (IBD) has been unresolved. Typically, the CMV genome remains dormant in infected cells, but a breakdown of immune surveillance can lead to re-ac... see more

Gun Kesa, Per H. Larsson, Niklas Ahlborg and Bernt Axelsson

We have evaluated a novel B-cell FluoroSpot assay for the analysis of antibody responses in healthy individuals vaccinated intramuscularly with Influenza A (H1N1) antigen (Pandemrix®, GlaxoSmithKline). Using the FluoroSpot assay and an ELISpot assay run i... see more