21 articles in this issue
Marcelina Parra, Seth Stahl and Hanjo Hellmann
Vitamin B6 is one of the most central molecules in cells of living organisms. It is a critical co-factor for a diverse range of biochemical reactions that regulate basic cellular metabolism, which impact overall physiology. In the last several years, majo... see more
Oleksandra Tiapko and Klaus Groschner
TRPC3 is one of the classical members of the mammalian transient receptor potential (TRP) superfamily of ion channels. TRPC3 is a molecule with intriguing sensory features including the direct recognition of and activation by diacylglycerols (DAG). Althou... see more
Giulia Sita, Patrizia Hrelia, Agnese Graziosi, Gloria Ravegnini and Fabiana Morroni
Transient receptor potential (TRP) proteins have been implicated in several cell functions as non-selective cation channels, with about 30 different mammalian TRP channels having been recognized. Among them, TRP-melastatin 2 (TRPM2) is particularly involv... see more
Eric Smith, Helen M. Palethorpe, Yoko Tomita, Jinxin V. Pei, Amanda R. Townsend, Timothy J. Price, Joanne P. Young, Andrea J. Yool and Jennifer E. Hardingham
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Alessandro Malara, Daniela Ligi, Christian A. Di Buduo, Ferdinando Mannello and Alessandra Balduini
Metalloproteinases (MMPs) are zinc-dependent endopeptidases that play essential roles as the mediator of matrix degradation and remodeling during organogenesis, wound healing and angiogenesis. Although MMPs were originally identified as matrixin proteases... see more
Jenna Lynne Wingfield and Karl-Ferdinand Lechtreck
Julien Guinde, Diane Frankel, Sophie Perrin, Valérie Delecourt, Nicolas Lévy, Fabrice Barlesi, Philippe Astoul, Patrice Roll and Elise Kaspi
Yunpeng Cao, Dandan Meng, Yu Chen, Muhammad Abdullah, Qing Jin, Yi Lin and Yongping Cai
Navid Sobhani, Anna Ianza, Alberto D’Angelo, Giandomenico Roviello, Fabiola Giudici, Marina Bortul, Fabrizio Zanconati, Cristina Bottin and Daniele Generali
Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis. In an era of personalized medicine, there is... see more
Elkin Navarro Quiroz, Roberto Navarro Quiroz, Mostapha Ahmad, Lorena Gomez Escorcia, Jose Luis Villarreal, Cecilia Fernandez Ponce and Gustavo Aroca Martinez
The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CN... see more
Xibao Liu, Hwei Ling Ong and Indu Ambudkar
Salivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely important role in the maintenance of oral health. Loss of salivary secretion causes a dry mouth condition, xerostomia, which has numerous deleterious consequences i... see more
Oliver J. Gruss
Sexual reproduction requires the generation of gametes, which are highly specialised for fertilisation. Female reproductive cells, oocytes, grow up to large sizes when they accumulate energy stocks and store proteins as well as mRNAs to enable rapid cell ... see more
Marina Del Fiacco, Maria Pina Serra, Marianna Boi, Laura Poddighe, Roberto Demontis, Antonio Carai and Marina Quartu
The presence of transient receptor potential vanilloid type-1 receptor (TRPV1)-like immunoreactivity (LI), in the form of nerve fibres and terminals, is shown in a set of discrete gray matter subregions placed in the territory of the human cuneate nucleus... see more
Daisuke Ito and Mónica Bettencourt-Dias
The centrosome is the major microtubule organizing centre (MTOC) in animal cells. The canonical centrosome is composed of two centrioles surrounded by a pericentriolar matrix (PCM). In contrast, yeasts and amoebozoa have lost centrioles and possess acentr... see more
Giuseppe A. Ramirez, Lavinia A. Coletto, Clara Sciorati, Enrica P. Bozzolo, Paolo Manunta, Patrizia Rovere-Querini and Angelo A. Manfredi
Allergy and autoimmune diseases are characterised by a multifactorial pathogenic background. Several genes involved in the control of innate and adaptive immunity have been associated with diseases and variably combine with each other as well as with envi... see more
Madison Turk, Victor Naumenko, Douglas J. Mahoney and Craig N. Jenne
Recent advances in imaging technology have made it possible to track cellular recruitment and behavior within the vasculature of living animals in real-time. Using approaches such as resonant scanning confocal and multiphoton intravital microscopy (IVM), ... see more
Charlotte Domblides, Lydia Lartigue and Benjamin Faustin
Innate and adaptive immune cells from myeloid and lymphoid lineages resolve host infection or cell stress by mounting an appropriate and durable immune response. Upon sensing of cellular insults, immune cells become activated and undergo rapid and efficie... see more
Tomer Avidor-Reiss
Centrioles are ancient subcellular protein-based organelles that maintain a conserved number and structure across many groups of eukaryotes. Centriole number (two per cells) is tightly regulated; each pre-existing centriole nucleates only one centriole as... see more
Sindora R. Baddam, Paul T. Arsenovic, Vani Narayanan, Nicole R. Duggan, Carl R. Mayer, Shaston T. Newman, Dahlia A. Abutaleb, Abhinav Mohan, Andrew P. Kowalczyk and Daniel E. Conway
Cell-cell junctions are critical structures in a number of tissues for mechanically coupling cells together, cell-to-cell signaling, and establishing a barrier. In many tissues, desmosomes are an important component of cell-cell junctions. Loss or impairm... see more
Julie C. Nielsen, Cathrine Nordgaard, Maxim A. X. Tollenaere and Simon Bekker-Jensen
Centriolar satellites (CS) are small proteinaceous granules that cluster around the centrosome and serve as cargo vehicles for centrosomal proteins. It is generally accepted that CS support a number of canonical and specialized centrosome functions. Conse... see more
Gianluca Sgarbi, Giulia Gorini, Francesca Liuzzi, Giancarlo Solaini and Alessandra Baracca
The role of reactive oxygen species (ROS) in the metabolic reprogramming of cells adapted to hypoxia and the interplay between ROS and hypoxia in malignancy is under debate. Here, we examined how ROS levels are modulated by hypoxia in human cancer compare... see more