8 articles in this issue
Eloise Keeling, Andrew J. Lotery, David A. Tumbarello and J. Arjuna Ratnayaka
Chronic degeneration of the Retinal Pigment Epithelium (RPE) is a precursor to pathological changes in the outer retina. The RPE monolayer, which lies beneath the neuroretina, daily internalises and digests large volumes of spent photoreceptor outer segme... see more
Jessica Fletcher, Liam Griffiths and Thomas Caspari
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Giulia Cazzanelli, Flávia Pereira, Sara Alves, Rita Francisco, Luísa Azevedo, Patrícia Dias Carvalho, Ana Almeida, Manuela Côrte-Real, Maria José Oliveira, Cândida Lucas, Maria João Sousa and Ana Preto
Pablo R. Duchowicz
A structurally diverse dataset of 530 polo-like kinase-1 (PLK1) inhibitors is compiled from the ChEMBL database and studied by means of a conformation-independent quantitative structure-activity relationship (QSAR) approach. A large number (26,761) of mol... see more
Graziella Curtale
Innate immune cells form an integrative component of the tumor microenvironment (TME), which can control or prevent tumor initiation and progression, due to the simultaneous processing of both anti- and pro-growth signals. This decision-making process is ... see more
Emilie Lukášová, Aleš Kovarík and Stanislav Kozubek
Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these int... see more
Felix Urusov, Dina Glazkova, Denis Omelchenko, Elena Bogoslovskaya, Galina Tsyganova, Katerina Kersting, German Shipulin and Vadim Pokrovsky
C-C chemokine receptor type 5 (CCR5) is utilized by human immunodeficiency virus (HIV) as a co-receptor for cell entry. Suppression of the CCR5 gene by artificial microRNAs (amiRNAs) could confer cell resistance. In previous work, we created a lentivector... see more
José Serrado Marques, Vera Teixeira, António Jacinto and Ana Teresa Tavares