Cells  

Masaki Hosoya and Katherine Czysz

Despite continuous efforts to improve the process of drug discovery and development, achieving success at the clinical stage remains challenging because of a persistent translational gap between the preclinical and clinical settings. Under these circumsta... see more

Marcel Kapahnke, Antje Banning and Ritva Tikkanen

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated sequence 9 (CRISPR/Cas9) system is widely used for genome editing purposes as it facilitates an efficient knockout of a specific gene in, e.g. cultured cells. Targeted doubl... see more

Mark Fields, Hui Cai, Jie Gong and Lucian Del Priore

The field of stem cell biology has rapidly evolved in the last few decades. In the area of regenerative medicine, clinical applications using stem cells hold the potential to be a powerful tool in the treatment of a wide variety of diseases, in particular... see more

Justine H. Dewald, Florent Colomb, Marie Bobowski-Gerard, Sophie Groux-Degroote and Philippe Delannoy

Glycosylation is one of the most important modifications of proteins and lipids, and cell surface glycoconjugates are thought to play important roles in a variety of biological functions including cell-cell and cell-substrate interactions, bacterial adhes... see more

Alexander V. Sirotkin

The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of ovarian functions at various regulatory levels. External and endocrine factors can affect female reproduction via SIRTs-mammalian target of rapamycin (mTOR) system... see more

Lauren J. Porter, Mark R. Holt, Daniel Soong, Catherine M. Shanahan and Derek T. Warren

Vascular smooth muscle cell (VSMC) motility is essential during both physiological and pathological vessel remodeling. Although ageing has emerged as a major risk factor in the development of cardiovascular disease, our understanding of the impact of agei... see more

Asma Yaghi and Myrna B. Dolovich

Airway epithelium is the first line of defense against exposure of the airway and lung to various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an important part of the mucociliary transport apparatus. To be effective in tra... see more

Hans-Werner Denker

“Organoids”, i.e., complex structures that can develop when pluripotent or multipotent stem cells are maintained in three-dimensional cultures, have become a new area of interest in stem cell research. Hopes have grown that when focussing experimentally o... see more

Sohair M. Khojah, Anthony P. Payne, Dagmara McGuinness and Paul G. Shiels

There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA ß-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different brain... see more

Subarna Dutta, Maitree Bhattacharyya and Kaushik Sengupta

Lamins are mechanosensitive and elastic components of the nuclear lamina that respond to external mechanical cues by altering gene regulation in a feedback mechanism. Numerous mutations in A-type lamins cause a plethora of diverse diseases collectively te... see more