Cells  

Jin Li, Deli Zhang, Marit Wiersma and Bianca J. J. M. Brundel

Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions. It has been... see more

Yoomi Chun and Joungmok Kim

Autophagy is a lysosome-dependent cellular degradation program that responds to a variety of environmental and cellular stresses. It is an evolutionarily well-conserved and essential pathway to maintain cellular homeostasis, therefore, dysfunction of auto... see more

Timothy Masiello, Atul Dhall, L. P. Madhubhani Hemachandra, Natalya Tokranova, J. Andres Melendez and James Castracane

The transcoelomic metastasis pathway is an alternative to traditional lymphatic/hematogenic metastasis. It is most frequently observed in ovarian cancer, though it has been documented in colon and gastric cancers as well. In transcoelomic metastasis, prim... see more

Mariangela Centrone, Maria Penelope De Santo, Isabella Nicotera, Cristina Labate, Marianna Ranieri, Annarita Di Mise, Maria Grazia Mola, Maria Mastrodonato, Rosangela Elliani, Riccardo Barberi, Vincenzo Formoso, Grazia Tamma and Giovanna Valenti

Vesicle fusion is a fundamental cell biological process similar from yeasts to humans. For secretory vesicles, swelling is considered a step required for the expulsion of intravesicular content. Here this concept is revisited providing evidence that it ma... see more

Olga N. Ivanova, Anastasiya V. Snezhkina, George S. Krasnov, Vladimir T. Valuev-Elliston, Olga A. Khomich, Alexey R. Khomutov, Tuomo A. Keinanen, Leena Alhonen, Birke Bartosch, Anna V. Kudryavtseva, Sergey N. Kochetkov and Alexander V. Ivanov

Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification within the local microenvironment. In particular, cancer cells exhibit elevated levels of biogeni... see more

Saima Kausar, Feng Wang and Hongjuan Cui

Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen species, and also have a biological role in antioxidant activities and Ca2+ ... see more

Sara Busatto, George Vilanilam, Taylor Ticer, Wen-Lang Lin, Dennis W. Dickson, Shane Shapiro, Paolo Bergese and Joy Wolfram

Concentration of extracellular vesicles (EVs) from biological fluids in a scalable and reproducible manner represents a major challenge. This study reports the use of tangential flow filtration (TFF) for the highly efficient isolation of EVs from large vo... see more

Silvia Pietrobono and Barbara Stecca

Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in mainta... see more

Alexandru Florin Rogobete, Dorel Sandesc, Ovidiu Horea Bedreag, Marius Papurica, Sonia Elena Popovici, Tiberiu Bratu, Calin Marius Popoiu, Razvan Nitu, Tiberiu Dragomir, Hazzaa I. M. AAbed and Mihaela Viviana Ivan

A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point ... see more

Weijie Xie, Ping Zhou, Yifan Sun, Xiangbao Meng, Ziru Dai, Guibo Sun and Xiaobo Sun

-

Meenakshi Agarwal, Ashish Pathak, Rajesh Singh Rathore, Om Prakash, Rakesh Singh, Rajneesh Jaswal, John Seaman and Ashvini Chauhan

-

Donata Orioli and Elena Dellambra

Skin undergoes continuous renewal throughout an individual’s lifetime relying on stem cell functionality. However, a decline of the skin regenerative potential occurs with age. The accumulation of senescent cells over time probably reduces tissue re... see more

Ruirui Wang, Min Wang, Kehao Chen, Shiyu Wang, Luis Alejandro Jose Mur and Shiwei Guo

Aquaporins (AQPs) are membrane channel proteins regulating the flux of water and other various small solutes across membranes. Significant progress has been made in understanding the roles of AQPs in plants’ physiological processes, and now their ac... see more

Lavinia L. Ruta, Melania A. Banu, Aurora D. Neagoe, Ralph Kissen, Atle M. Bones and Ileana C. Farcasanu

-

Hamidreza Maroof, Farhadul Islam, LanFeng Dong, Prabha Ajjikuttira, Vinod Gopalan, Nigel A.J. McMillan and Alfred K. Lam

-

Chiara Volani, Giuseppe Paglia, Sigurdur V. Smarason, Peter P. Pramstaller, Egon Demetz, Christa Pfeifhofer-Obermair and Guenter Weiss

Iron is an essential co-factor for several metabolic processes, including the Krebs cycle and mitochondrial oxidative phosphorylation. Therefore, maintaining an appropriate iron balance is essential to ensure sufficient energy production and to avoid exce... see more

Abdalla Abdrabou and Zhixiang Wang

Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhes... see more

Chien-Yu Huang, Po-Li Wei, Wei-Yu Chen, Wei-Chiao Chang and Yu-Jia Chang

The incidence of colorectal cancer (CRC) has significantly increased in recent decades, and this disease has become an important health issue worldwide. Currently, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (HSP27... see more

Sergey A. Sinenko, Elena V. Skvortsova, Mikhail A. Liskovykh, Sergey V. Ponomartsev, Andrey A. Kuzmin, Aleksandr A. Khudiakov, Anna B. Malashicheva, Natalia Alenina, Vladimir Larionov, Natalay Kouprina and Alexey N. Tomilin

AlphoidtetO-type human artificial chromosome (HAC) has been recently synthetized as a novel class of gene delivery vectors for induced pluripotent stem cell (iPSC)-based tissue replacement therapeutic approach. This HAC vector was designed to deliver copi... see more

Sanja Stojanovic, Stevo Najman and Aleksandra Korac

Lipomas are benign adipose tissue tumors of unknown etiology, which can vary in size, number, body localization and cell populations within the tissue. Lipoma-derived stem cells (LDSCs) are proposed as a potential tool in regenerative medicine and tissue ... see more

Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Anna Laemmerer, Patrick Moser, Lisa Gabler, Diana Groza, Christian R. Kowol, Petra Heffeter, Michael Grusch and Walter Berger

Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for understanding drug efficacy as well as intrinsic and acquired cellular resistance mechanisms. However, the factors driving subcellular drug distribution are complex and poo... see more

Can Wang, Zhuo Ma, Dong-Ying Yan, Chang Liu, Yu Deng, Wei Liu, Zhao-Fa Xu and Bin Xu

Synaptic vesicle fusion is mediated by an assembly of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptors (SNAREs), composed of syntaxin 1, soluble NSF-attachment protein (SNAP)-25, and synaptobrevin-2/VAMP-2. Previous studies h... see more

Ping Wee and Zhixiang Wang

The overactivation of epidermal growth factor (EGF) receptor (EGFR) is implicated in various cancers. Endocytosis plays an important role in EGFR-mediated cell signaling. We previously found that EGFR endocytosis during mitosis is mediated differently fro... see more

Chantal Guindi, Alexandre Cloutier, Simon Gaudreau, Echarki Zerif, Patrick P. McDonald, Olga Tatsiy, Claude Asselin, Gilles Dupuis, Denis Gris and Abdelaziz Amrani

Dendritic cells (DCs) play a major role in innate and adaptive immunity and self-immune tolerance. Immunogenic versus tolerogenic DC functions are dictated by their levels of costimulatory molecules and their cytokine expression profile. The transcription... see more

Miruna Mihaela Micheu, Alina Ioana Scarlatescu, Alexandru Scafa-Udriste and Maria Dorobantu

Despite significant progress in treating ischemic cardiac disease and succeeding heart failure, there is still an unmet need to develop effective therapeutic strategies given the persistent high-mortality rate. Advances in stem cell biology hold great pro... see more

Soyoung Park, Yohan Lim, Duckgue Lee, Rosalie Elvira, Ji-Min Lee, Man Ryul Lee and Jaeseok Han

Global warming poses a considerable threat to human health, necessitating a proper understanding of mechanisms underlying cell death in the pathogenesis of heat-related diseases. Although mechanisms governing cytoplasmic response to heat are well understo... see more

Lubos Danisovic, Martina Culenova and Maria Csobonyeiova

-

Wei Zhang, Feng Zhao, Lihui Jiang, Cun Chen, Lintao Wu and Zhibin Liu

Plants constantly suffer from simultaneous infection by multiple pathogens, which can be divided into biotrophic, hemibiotrophic, and necrotrophic pathogens, according to their lifestyles. Many studies have contributed to improving our knowledge of how pl... see more

Vinicius Guzzoni, Heloisa Sobreiro Selistre-de-Araújo and Rita De Cássia Marqueti

Exercise training (ET), anabolic androgenic steroids (AAS), and aging are potential factors that affect tendon homeostasis, particularly extracellular matrix (ECM) remodeling. The goal of this review is to aggregate findings regarding the effects of resis... see more

Adel Alhazzani, Prasanna Rajagopalan, Zaher Albarqi, Anantharam Devaraj, Mohamed Hessian Mohamed, Ahmed Al-Hakami and Harish C. Chandramoorthy

Cell-therapy modalities using mesenchymal stem (MSCs) in experimental strokes are being investigated due to the role of MSCs in neuroprotection and regeneration. It is necessary to know the sequence of events that occur during stress and how MSCs compleme... see more