Cells  

Stuart J. Mills, Allison J. Cowin and Pritinder Kaur

Pericytes are cells that reside on the wall of the blood vessels and their primary function is to maintain the vessel integrity. Recently, it has been realized that pericytes have a much greater role than just the maintenance of vessel integrity essential... see more

Chenggang Jin, Diana R. Roen, Paul V. Lehmann and Gottfried H. Kellermann

Lyme Borreliosis is an infectious disease caused by the spirochete Borrelia burgdorferi that is transmitted through the bite of infected ticks. Both B cell-mediated humoral immunity and T cell immunity develop during natural Borrelia infection. However, c... see more

Thomas A. Robertson, Florestan Bunel and Michael S. Roberts

Intravital fluorescence microscopy enables the direct imaging of fluorophores in vivo and advanced techniques such as fluorescence lifetime imaging (FLIM) enable the simultaneous detection of multiple fluorophores. Consequently, it is now possible to reco... see more

Ida Annunziata and Alessandra D'Azzo

The dynamic interplay among intracellular organelles occurs at specific membrane tethering sites, where two organellar membranes come in close apposition but do not fuse. Such membrane microdomains allow for rapid and efficient interorganelle communicatio... see more

Eric Hervouet, Mathilde Cheray, François Marie Vallette and Pierre-François Cartron

Apoptosis is a cell death programme primordial to cellular homeostasis efficiency. This normal cell suicide program is the result of the activation of a cascade of events in response to death stimuli. Apoptosis occurs in normal cells to maintain a balance... see more

Bashar Ibrahim, Richard Henze, Gerd Gruenert, Matthew Egbert, Jan Huwald and Peter Dittrich

Yujing Sun, Ting Gui, Aiko Shimokado and Yasuteru Muragaki

TRPS1 is a GATA-type transcription factor that is closely related to human tricho-rhino-phalangeal syndrome (TRPS) types I and III, variants of an autosomal dominant skeletal disorder. During embryonic development, Trps1 represses Sox9 expression and regu... see more

Uwe Warnken, Kolja Schleich, Martina Schnölzer and Inna Lavrik

Contemporary quantitative mass spectrometry provides fascinating opportunities in defining the stoichiometry of high-molecular weight complexes or multiprotein platforms. The composition stoichiometry of multiprotein platforms is a key to understand the r... see more

Sreedhar Thirumala, Jeffrey M. Gimble and Ram V. Devireddy

The thermoresponsive behavior of a Methylcellulose (MC) polymer was systematically investigated to determine its usability in constructing MC based hydrogel systems in cell sheet engineering applications. Solution-gel analyses were made to study the effec... see more