30 articles in this issue
Srinivasan Vedantham, Anna-Kristina Kluever and Elisabeth Deindl
Cardiovascular diseases (CVD) are still the prevailing cause of death not only in industrialized countries, but even worldwide. Type 2 diabetes mellitus (type 2 DM) and hyperlipidemia, a metabolic disorder that is often associated with diabetes, are major... see more
Yangmin X. Kim, Burkhard Stumpf, Jwakyung Sung and Sang Joon Lee
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M Carmen Martinez-Ballesta, Paula Garcia-Ibañez, Lucía Yepes-Molina, Juan José Rios and Micaela Carvajal
In animals and plants, membrane vesicles containing proteins have been defined as key for biological systems involving different processes such as trafficking or intercellular communication. Docking and fusion of vesicles to the plasma membrane occur in l... see more
Nadezda V. Andrianova, Stanislovas S. Jankauskas, Ljubava D. Zorova, Irina B. Pevzner, Vasily A. Popkov, Denis N. Silachev, Egor Y. Plotnikov and Dmitry B. Zorov
Dietary restriction (DR) is one of the most efficient approaches ameliorating the severity of different pathological conditions including aging. We investigated the protective potential of short-term DR in the model of acute kidney injury (AKI) in young a... see more
Po Yee Chung, Pik Ling Lam, Yuanyuan Zhou, Jessica Gasparello, Alessia Finotti, Adriana Chilin, Giovanni Marzaro, Roberto Gambari, Zhaoxiang Bian, Wai Ming Kwok, Wai Yeung Wong, Xi Wang, Alfred King-yin Lam, Albert Sun-chi Chan, Xingshu Li, Jessica Yuen Wuen Ma, Chung Hin Chui, Kim Hung Lam and Johnny Cheuk On Tang
Andrew Paul, Joanne Edwards, Christopher Pepper and Simon Mackay
The cellular kinases inhibitory-κB kinase (IKK) α and Nuclear Factor-κB (NF-κB)-inducing kinase (NIK) are well recognised as key central regulators and drivers of the non-canonical NF-κB cascade and as such dictate the initia... see more
Magdalena Dziegala, Kamil A. Kobak, Monika Kasztura, Jacek Bania, Krystian Josiak, Waldemar Banasiak, Piotr Ponikowski and Ewa A. Jankowska
Andrea M. Halsey, Alex C. Conner, Roslyn M. Bill, Ann Logan and Zubair Ahmed
After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissu... see more
Mahmoud Farrag and Nic D. Leipzig
A combinatorial approach integrating stem cells and capable of exploiting available cues is likely needed to regenerate lost neural tissues and ultimately restore neurologic functions. This study investigates the effects of the subcutaneous maturation of ... see more
Braulio Vargas Möller-Hergt, Andreas Carlström, Tamara Suhm and Martin Ott
Rohit Gundamaraju, Ravichandra Vemuri, Wai Chin Chong, Stephen Myers, Shaghayegh Norouzi, Madhur D. Shastri and Rajaraman Eri
Elisabetta Mattioli, Marta Columbaro, Mohammed Hakim Jafferali, Elisa Schena, Einar Hallberg and Giovanna Lattanzi
Tomer Harpaz, Heba Abumock, Einat Beery, Yonatan Edel, Meir Lahav, Uri Rozovski and Orit Uziel
Telomeres (TLs) protect chromosome ends from chromosomal fusion and degradation, thus conferring genomic stability, and play crucial roles in cellular aging and disease. Recent studies have found a correlation between environmental, physiological and even... see more
Shuya Yano and Robert M. Hoffman
Most cytotoxic agents have limited efficacy for solid cancers. Cell-cycle phase analysis at the single-cell level in solid tumors has shown that the majority of cancer cells in tumors is not cycling and is therefore resistant to cytotoxic chemotherapy. In... see more
Muhammad Nawaz, Neelam Shah, Bruna Riedo Zanetti, Marco Maugeri, Renata Nacasaki Silvestre, Farah Fatima, Luciano Neder and Hadi Valadi
Extracellular vesicles (EVs) are membrane enclosed micro- and nano-sized vesicles that are secreted from almost every species, ranging from prokaryotes to eukaryotes, and from almost every cell type studied so far. EVs contain repertoire of bioactive mole... see more
Martha Wium, Juliano D. Paccez and Luiz F. Zerbini
Receptor tyrosine kinases (RTKs) regulate cellular processes by converting signals from the extracellular environment to the cytoplasm and nucleus. Tyro3, Axl, and Mer (TAM) receptors form an RTK family that plays an intricate role in tissue maintenance, ... see more
Muttiah Barathan, Rosmawati Mohamed, Yean K. Yong, Meganathan Kannan, Jamuna Vadivelu, Alireza Saeidi, Marie Larsson and Esaki Muthu Shankar
Hepatitis C virus (HCV) represents a challenging global health threat to ~200 million infected individuals. Clinical data suggest that only ~10–15% of acutely HCV-infected individuals will achieve spontaneous viral clearance despite exuberant virus-... see more
Mohamed Altai, Charles Dahlsson Leitao, Sara S. Rinne, Anzhelika Vorobyeva, Christina Atterby, Stefan Ståhl, Vladimir Tolmachev, John Löfblom and Anna Orlova
Overexpression of human epidermal growth factor receptor type 3 (HER3) is associated with tumour cell resistance to HER-targeted therapies. Monoclonal antibodies (mAbs) targeting HER3 are currently being investigated for treatment of various types of canc... see more
Magdalena Opalinska and Hanna Janska
Milton O. Aguilera, Laura R. Delgui, Patricia S. Romano and María I. Colombo
Multiple tissues and systems in the organism undergo modifications during aging due to an accumulation of damaged proteins, lipids, and genetic material. To counteract this process, the cells are equipped with specific mechanisms, such as autophagy and se... see more
Hooi-Yeen Yap, Sabrina Zi-Yi Tee, Magdelyn Mei-Theng Wong, Sook-Khuan Chow, Suat-Cheng Peh and Sin-Yeang Teow
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern. This disorder usually does not directly cause death but significantly reduces the qualit... see more
Valeria Tosello, Gloria Milani, Annalisa Martines, Nadia Macri, Wouder Van Loocke, Filip Matthijssens, Barbara Buldini, Sonia Minuzzo, Deborah Bongiovanni, Richard Fabian Schumacher, Alberto Amadori, Pieter Van Vlierberghe and Erich Piovan
Ewa Ambrozewicz, Piotr Wójcik, Adam Wronski, Wojciech Luczaj, Anna Jastrzab, Neven Žarkovic and Elzbieta Skrzydlewska
Inflammatory granulocytes are characterized by an oxidative burst, which may promote oxidative stress and lipid modification both in affected tissues and on a systemic level. On the other hand, redox signaling involving lipid peroxidation products acting ... see more
Patrizia Procacci, Claudia Moscheni, Patrizia Sartori, Michele Sommariva and Nicoletta Gagliano
The extracellular matrix (ECM) in the tumor microenvironment modulates the cancer cell phenotype, especially in pancreatic ductal adenocarcinoma (PDAC), a tumor characterized by an intense desmoplastic reaction. Because the epithelial-to-mesenchymal trans... see more
Jingyu Chen and Lesley A. Stark
Nucleoli are emerging as key sensors of cellular stress and regulators of the downstream consequences on proliferation, metabolism, senescence, and apoptosis. NF-κB signalling is activated in response to a similar plethora of stresses, which leads t... see more
Noemi Di Marzo, Elisa Chisci and Roberto Giovannoni
Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox metabolism reactions and processes of the cells. H2O2 is recognized as one of the main molecules in the sensing, modulation and signaling of redox metabolism, and it is acti... see more
Charlotte Graham, Agnieszka Jozwik, Andrea Pepper and Reuben Benjamin
Patient derived anti-CD19 chimeric antigen receptor-T (CAR-T) cells are a powerful tool in achieving a complete remission in a range of B-cell malignancies, most notably B-acute lymphoblastic leukaemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL). Ho... see more
Celia Salazar, Paula Ruiz-Hincapie and Lina María Ruiz
Raquel L. Bernardino, David F. Carrageta, Ana M. Silva, Giuseppe Calamita, Marco G. Alves, Graça Soveral and Pedro F. Oliveira
High 17β-Estradiol (E2) levels are known to cause alterations of spermatogenesis and environments throughout the male reproductive tract. Sertoli cells (SCs) ensure an adequate environment inside the seminiferous tubule. Glycerol stands as essential ... see more
Umama Shahid and Priyanka Singh
Multiciliated cells (MCCs) have several hair-like structures called cilia, which are required to propel substances on their surface. A cilium is organized from a basal body which resembles a hollow microtubule structure called a centriole. In terminally d... see more