30 articles in this issue
Tawfeek Altawaty, Lulu Liu, Hongyong Zhang, Cong Tao, Shaohua Hou, Kui Li and Yanfang Wang
The essential requirement of the lymphotoxin beta receptor (LTβR) in the development and maintenance of peripheral lymphoid organs is well recognized. Evidence shows that LTβR is involved in various cellular processes; however, whether it plays ... see more
Friederike K. Kosyna and Reinhard Depping
Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essen... see more
Michela Deiana, Luca Dalle Carbonare, Michela Serena, Samuele Cheri, Francesca Parolini, Alberto Gandini, Giulia Marchetto, Giulio Innamorati, Marcello Manfredi, Emilio Marengo, Jessica Brandi, Daniela Cecconi, Antonio Mori, Maria Mihaela Mina, Franco Antoniazzi, Monica Mottes, Natascia Tiso, Giovanni Malerba, Donato Zipeto and Maria Teresa Valenti
The mortality rate for malignant melanoma (MM) is very high, since it is highly invasive and resistant to chemotherapeutic treatments. The modulation of some transcription factors affects cellular processes in MM. In particular, a higher expression of the... see more
Claudia Ricci, Carlotta Marzocchi and Stefania Battistini
Amyotrophic lateral sclerosis (ALS) is an incurable and fatal disorder characterized by the progressive loss of motor neurons in the cerebral cortex, brain stem, and spinal cord. Sporadic ALS form accounts for the majority of patients, but in 1–13.5... see more
Michael Mederos y Schnitzler, Thomas Gudermann and Ursula Storch
Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels. TRPC4 and TRPC5 channels are widely accepted as... see more
Chih-Hsuan Hsia, Marappan Velusamy, Thanasekaran Jayakumar, Yen-Jen Chen, Chih-Wei Hsia, Jie-Heng Tsai, Ruei-Dun Teng and Joen-Rong Sheu
Several studies have reported that metal complexes exhibit anti-inflammatory activities; however, the molecular mechanism is not well understood. In this study, we used a potent ruthenium (II)-derived compound, [Ru(η6-cymene)2-(1H-benzoimidazol-2-yl)-... see more
Urszula Majcher, Greta Klejborowska, Magdalena Kaik, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski and Adam Huczynski
Specific modifications of colchicine followed by synthesis of its analogues have been tested in vitro with the objective of lowering colchicine toxicity. Our previous studies have clearly shown the anticancer potential of double-modified colchicine deriva... see more
Yoshihiko Kuchitsu and Mitsunori Fukuda
Rab7 (or Ypt7 in yeast) is one of the well-characterized members of the Rab family small GTPases, which serve as master regulators of membrane trafficking in eukaryotes. It localizes to late endosomes and lysosomes and has multiple functions in the autoph... see more
Cécile Polge, Julien Aniort, Andrea Armani, Agnès Claustre, Cécile Coudy-Gandilhon, Clara Tournebize, Christiane Deval, Lydie Combaret, Daniel Béchet, Marco Sandri, Didier Attaix and Daniel Taillandier
Skeletal muscle mass is reduced during many diseases or physiological situations (disuse, aging), which results in decreased strength and increased mortality. Muscle mass is mainly controlled by the ubiquitin-proteasome system (UPS), involving hundreds of... see more
Sandra Maaß, Andreas Otto, Dirk Albrecht, Katharina Riedel, Anke Trautwein-Schult and Dörte Becher
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Tatsuya Nagano, Motoko Tachihara and Yoshihiro Nishimura
Kwanhyeong Kim, Juyeon Lee, Hyunji Moon, Sang-Ah Lee, Deokhwan Kim, Susumin Yang, Dae-Hee Lee, Gwangrog Lee and Daeho Park
Ephexin4 is a guanine nucleotide-exchange factor (GEF) for RhoG and is involved in various RhoG-related cellular processes such as phagocytosis of apoptotic cells and migration of cancer cells. Ephexin4 forms an oligomer via an intermolecular interaction,... see more
Ibrahim González-Marrero, Luis G. Hernández-Abad, Emilia M. Carmona-Calero, Leandro Castañeyra-Ruiz, José A. Abreu-Reyes and Agustín Castañeyra-Perdomo
Aquaporin 1 (AQP1) and aquaporin 4 (AQP4) have been identified in the eye as playing an essential role in the formation of the aqueous humor along with the Na+/K+ ATPase pump. Different authors have described the relationship between blood pressure, aqueo... see more
Marcelo Ozu, Luciano Galizia, Cynthia Acuña and Gabriela Amodeo
Aquaporins (AQPs) function as tetrameric structures in which each monomer has its own permeable pathway. The combination of structural biology, molecular dynamics simulations, and experimental approaches has contributed to improve our knowledge of how pro... see more
Ita Novita Sari, Lan Thi Hanh Phi, Nayoung Jun, Yoseph Toni Wijaya, Sanghyun Lee and Hyog Young Kwon
The Hedgehog (Hh) pathway is a signaling cascade that plays a crucial role in many fundamental processes, including embryonic development and tissue homeostasis. Moreover, emerging evidence has suggested that aberrant activation of Hh is associated with n... see more
Andreia F. Mósca, Andreia De Almeida, Darren Wragg, Ana P. Martins, Farzana Sabir, Stefano Leoni, Teresa F. Moura, Catarina Prista, Angela Casini and Graça Soveral
José Paulo De Pizzol Júnior, Estela Sasso-Cerri and Paulo Sérgio Cerri
Tamar Segal, Mali Salmon-Divon and Gabi Gerlitz
H3K9me3, H3K27me3, and H4K20me1 are epigenetic markers associated with chromatin condensation and transcriptional repression. Previously, we found that migration of melanoma cells is associated with and dependent on global chromatin condensation that incl... see more
Daniela Ribeiro, Marisa Freitas, Sílvia Rocha, José L. F. C. Lima, Félix Carvalho and Eduarda Fernandes
In neutrophils, intracellular Ca2+ levels are regulated by several transporters and pathways, namely SERCA [sarco(endo)plasmic reticulum Ca2+-ATPase], SOCE (store-operated calcium entry), and ROCE (receptor-operated calcium entry). However, the exact mech... see more
Adele Vivacqua, Anna Sebastiani, Anna Maria Miglietta, Damiano Cosimo Rigiracciolo, Francesca Cirillo, Giulia Raffaella Galli, Marianna Talia, Maria Francesca Santolla, Rosamaria Lappano, Francesca Giordano, Maria Luisa Panno and Marcello Maggiolini
Estrogens acting through the classic estrogen receptors (ERs) and the G protein estrogen receptor (GPER) regulate the expression of diverse miRNAs, small sequences of non-coding RNA involved in several pathophysiological conditions, including breast cance... see more
Ralph Gräf
Ethan Chernivec, Jacie Cooper and Kari Naylor
Bruna F. Pinto, Nayara I. Medeiros, Tereza C. M. Fontes-Cal, Isabela M. Naziazeno, Rodrigo Correa-Oliveira, Walderez O. Dutra and Juliana A. S. Gomes
Xiaolan Chen, Hongjia Ouyang, Zhijun Wang, Biao Chen and Qinghua Nie
Juhyung Lee and Yihong Ye
Protein secretion in general depends on signal sequence (also named leader sequence), a hydrophobic segment located at or close to the NH2-terminus of a secretory or membrane protein. This sequence guides the entry of nascent polypeptides into the lumen o... see more
Rosanna Avola, Adriana Carol Eleonora Graziano, Giovanna Pannuzzo and Venera Cardile
The development in digital screen technology has exponentially increased in the last decades, and many of today’s electronic devices use light-emitting diode (LED) technology producing very strong blue light (BL) waves. Long-term exposure at LED-BL ... see more
Pilar Garcia-Broncano, Luz Maria Medrano, Juan Berenguer, Juan González-García, Mª Ángeles Jiménez-Sousa, Ana Carrero, Victor Hontañón, Josep M. Guardiola, Manuel Crespo, Carmen Quereda, José Sanz, Ana Belen García-Gómez, Jose Luis Jimenez, Salvador Resino and The GESIDA 3603b Study Group
Huayu Sun, Sining Wang, Yongfeng Lou, Chenglei Zhu, Hansheng Zhao, Ying Li, Xueping Li and Zhimin Gao
Shuyuan Wang, Wencan Wang, Qianqian Meng, Shunheng Zhou, Haizhou Liu, Xueyan Ma, Xu Zhou, Hui Liu, Xiaowen Chen and Wei Jiang
Autophagy is a complex cellular digestion process involving multiple regulators. Compared to post-translational autophagy regulators, limited information is now available about transcriptional and post-transcriptional regulators such as transcription fact... see more
Bruna Silva Oliveira, Catherine M. Pirkle, Maria Victoria Zunzunegui, Silvia Regina Batistuzzo de Medeiros, Ronaldo Luis Thomasini and Ricardo Oliveira Guerra