Cells  

Michael Batie, Jimena Druker, Laura D’Ignazio and Sonia Rocha

Hypoxia is not only a developmental cue but also a stress and pathological stimulus in many human diseases. The response to hypoxia at the cellular level relies on the activity of the transcription factor family, hypoxia inducible factor (HIF). HIF-1 is r... see more

Mailin Li, Pasquale Cascino, Simone Ummarino and Annalisa Di Ruscio

The burst of reprogramming technology in recent years has revolutionized the field of stem cell biology, offering new opportunities for personalized, regenerative therapies. The direct reprogramming of somatic cells to induced pluripotent stem cells (iPSC... see more

Robert Lindner

Invariant chain (Ii/CD74) has been identified as a surface receptor for migration inhibitory factor (MIF). Most cells that express Ii also synthesize major histocompatibility complex class II (MHC II) molecules, which depend on Ii as a chaperone and a tar... see more

Nicholas Brookhouser, Sreedevi Raman, Christopher Potts and David. A. Brafman

In the decade since Yamanaka and colleagues described methods to reprogram somatic cells into a pluripotent state, human induced pluripotent stem cells (hiPSCs) have demonstrated tremendous promise in numerous disease modeling, drug discovery, and regener... see more

Aakriti Garg, Jin Yang, Winston Lee and Stephen H. Tsang

Stem cell therapy has long been considered a promising mode of treatment for retinal conditions. While human embryonic stem cells (ESCs) have provided the precedent for regenerative medicine, the development of induced pluripotent stem cells (iPSCs) revol... see more

Miki Hieda

The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins. Increasing evidence has point... see more

Emmanuel Terriac, Giovanna Coceano, Zahra Mavajian, Tijmen A. G. Hageman, Andreas F. Christ, Ilaria Testa, Franziska Lautenschläger and Annica K. B. Gad

Metastasizing tumor cells show increased expression of the intermediate filament (IF) protein vimentin, which has been used to diagnose invasive tumors for decades. Recent observations indicate that vimentin is not only a passive marker for carcinoma, but... see more

Cells Editorial Office

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