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16  Articles
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The mechanical bidomain model is a mathematical description of biological tissue that focuses on mechanotransduction. The model’s fundamental hypothesis is that differences in the intracellular and extracellular displacements activate integrins, causing a... see more

Cardiac fibrosis, the excessive accumulation of extracellular matrix (ECM), remains an unresolved problem in most forms of heart disease. In order to be successful in preventing, attenuating or reversing cardiac fibrosis, it is essential to understand the... see more

New effective methods of extremities gunshot wounds treatment development has acquired a great importance because of military operations on theterritoryofDonetskand Lugansk regions ofUkraine. The development of the technological process in medical practic... see more

Objective Prolonged immobilization or unloading of skeletal muscle causes muscle disuse atrophy, which is characterized by a reduction in muscle cross-sectional area and compromised contractile function. To date, the mechanisms of anabolic mechanotransduc... see more

In the last years, many papers highlighted the possibility to use epigenetic modifiers to directly interact with the epigenetic signature of an adult mature cell (Pennarossa et al., 2013; Chandrakantan et al., 2016). In particular, the molecule 5-azacytid... see more

Compressibility influences the mechanical bidomain model describing the elastic properties of the tissue. In this model, the displacements of the intracellular and extracellular spaces are analyzed individually, and differences in these displacements give... see more


The heart is a mechanically-active organ that dynamically senses its own mechanical environment. This environment is constantly changing, on a beat-by-beat basis, with additional modulation by respiratory activity and changes in posture or physical activi... see more

Quantification of the actin cytoskeleton is of prime importance to unveil the cellular force sensing and transduction mechanism. Although fluorescence imaging provides a convenient tool for observing the morphology of the actin cytoskeleton, due to the la... see more

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