Cells  

Christina N. Cheng, Valerie A. Verdun and Rebecca A. Wingert

The kidney is comprised of working units known as nephrons, which are epithelial tubules that contain a series of specialized cell types organized into a precise pattern of functionally distinct segment domains. There is a limited understanding of the gen... see more

Mona Grimmel, Charlotte Backhaus and Tassula Proikas-Cezanne

Autophagy is a lysosomal degradation process for cytoplasmic components, including organelles, membranes, and proteins, and critically secures eukaryotic cellular homeostasis and survival. Moreover, autophagy-related (ATG) genes are considered essential f... see more

Izma Abdul Zani, Sam L. Stephen, Nadeem A. Mughal, David Russell, Shervanthi Homer-Vanniasinkam, Stephen B. Wheatcroft and Sreenivasan Ponnambalam

Scavenger receptors (SRs) are a ‘superfamily’ of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous protein... see more

José A. Morales-González, Eduardo Madrigal-Santillán, Ángel Morales-González, Mirandeli Bautista, Evila Gayosso-Islas and Cecilia Sánchez-Moreno

It has been known for years that, after chemical damage or surgical removal of its tissue, the liver initiates a series of changes that, taken together, are known as regeneration, which are focused on the recovery of lost or affected tissue in terms of th... see more

Emily Koeneke, Olaf Witt and Ina Oehme

The exploitation of autophagy by some cancer entities to support survival and dodge death has been well-described. Though its role as a constitutive process is important in normal, healthy cells, in the milieu of malignantly transformed and highly prolife... see more

Radleigh Santos, Alcinette Buying, Nazila Sabri, John Yu, Anthony Gringeri, James Bender, Sylvia Janetzki, Clemencia Pinilla and Valeria A. Judkowski

Mirja Krause, Aleksandra Rak-Raszewska, Ilkka Pietilä, Susan E. Quaggin and Seppo Vainio

The kidney plays an essential role during excretion of metabolic waste products, maintenance of key homeostasis components such as ion concentrations and hormone levels. It influences the blood pressure, composition and volume. The kidney tubule system is... see more