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135  Articles
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Background: Cancer is a term that is used to describe a wide range of diseases, but they all have some characteristics in common. The goal of this review is to highlight the most commonly used cancer models as well as their role in tumor biology. Although... see more

 

The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective... see more

Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure an... see more

Prostate cancer (PCa) is one of the most common cancers and among the leading causes of cancer deaths for men in industrialized countries. It has long been recognized that the prostate is an androgen-dependent organ and PCa is an androgen-dependent diseas... see more

Functional genomics has provided evidence that the human genome transcribes a large number of non-coding genes in addition to protein-coding genes, including microRNAs and long non-coding RNAs (lncRNAs). Among the group of lncRNAs are pseudogenes that hav... see more

BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the regulation and differentiation of breast tumorigenesis. Some ERa polymorphisms, including ERa rs3798577, are reported to be associated with the risk and aggressiveness o... see more

Inflammation plays an important role to the development of cancer and promotes all stages of tumorigenesis. Cancer cells, as well as inflammatory cells, carry out reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cancer cells w... see more

BACKGROUND: Interaction between estrogen and estrogen receptor (ER) takes part in the regulation and differentiation of breast tumorigenesis. Some ERa polymorphisms, including ERa rs3798577, are reported to be associated with the risk and aggressiveness o... see more

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