30 articles in this issue
Takahiro Sakai, Ryosuke Kurokawa, Shin-ichi Hirano and Jun Imai
Bacteria inhabiting the human gut metabolize microbiota-accessible carbohydrates (MAC) contained in plant fibers and subsequently release metabolic products. Gut bacteria produce hydrogen (H2), which scavenges the hydroxyl radical (•OH). Because H2 d... see more
Felix Beyer, Iria Samper Agrelo and Patrick Küry
The adult mammalian central nervous system (CNS) is generally considered as repair restricted organ with limited capacities to regenerate lost cells and to successfully integrate them into damaged nerve tracts. Despite the presence of endogenous immature ... see more
Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang and Chia-Hwa Lee
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Marwa Almosailleakh and Juerg Schwaller
Acute myeloid leukaemia (AML) is a rare but severe form of human cancer that results from a limited number of functionally cooperating genetic abnormalities leading to uncontrolled proliferation and impaired differentiation of hematopoietic stem and proge... see more
Bilal Haider Abbasi, Aisha Siddiquah, Duangjai Tungmunnithum, Shankhamala Bose, Muhammad Younas, Laurine Garros, Samantha Drouet, Nathalie Giglioli-Guivarc’h and Christophe Hano
Shinnosuke Ishikawa, José Barrero, Fuminori Takahashi, Scott Peck, Frank Gubler, Kazuo Shinozaki and Taishi Umezawa
Dormancy is the mechanism that allows seeds to become temporally quiescent in order to select the right time and place to germinate. Like in other species, in barley, grain dormancy is gradually reduced during after-ripening. Phosphosignaling networks in ... see more
Rebecca Njeri Damaris, Zhongyuan Lin, Pingfang Yang and Dongli He
Alpha-amylase, the major form of amylase with secondary carbohydrate binding sites, is a crucial enzyme throughout the growth period and life cycle of angiosperm. In rice, alpha-amylase isozymes are critical for the formation of the storage starch granule... see more
Chengzhu Liao, Yuchao Li and Sie Chin Tjong
Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic and healthcare products, antimicrobial textiles, wound ... see more
Ingo Gerhauser, Florian Hansmann, Malgorzata Ciurkiewicz, Wolfgang Löscher and Andreas Beineke
Kathrin Maly, Inna Schaible, Jana Riegger, Rolf E. Brenner, Andrea Meurer and Frank Zaucke
Osteoarthritis (OA) is a progressive joint disease characterized by a continuous degradation of the cartilage extracellular matrix (ECM). The expression of the extracellular glycoprotein thrombospondin-4 (TSP-4) is known to be increased in injured tissues... see more
Abdellah Tebani, Lenaig Abily-Donval, Isabelle Schmitz-Afonso, Monique Piraud, Jérôme Ausseil, Farid Zerimech, Carine Pilon, Tony Pereira, Stéphane Marret, Carlos Afonso and Soumeya Bekri
Metabolic phenotyping is poised as a powerful and promising tool for biomarker discovery in inherited metabolic diseases. However, few studies applied this approach to mcopolysaccharidoses (MPS). Thus, this innovative functional approach may unveil compre... see more
Chloe-Anne Martinez, Bernadette Kerr, Charley Jin, Peter A. Cistulli and Kristina M. Cook
Giovanna Ferrara, Maria Grazia Petrillo, Teresa Giani, Edoardo Marrani, Cesare Filippeschi, Teresa Oranges, Gabriele Simonini and Rolando Cimaz
Corticosteroids are the mainstay of therapy for many pediatric disorders and sometimes are life-saving. Both endogenous and synthetic derivatives diffuse across the cell membrane and, by binding to their cognate glucocorticoid receptor, modulate a variety... see more
Maria A. Streltsova, Sofya A. Erokhina, Leonid M. Kanevskiy, Maria V. Grechikhina, Polina A. Kobyzeva, Dean A. Lee, William G. Telford, Alexander M. Sapozhnikov and Elena I. Kovalenko
A pattern of natural killer cell (NK cell) heterogeneity determines proliferative and functional responses to activating stimuli in individuals. Obtaining the progeny of a single cell by cloning the original population is one of the ways to study NK cell ... see more
Christine E. Tanna, Louisa B. Goss, Calvin G. Ludwig and Pei-Wen Chen
Arf GTPase-activating proteins (Arf GAPs) control the activity of ADP-ribosylation factors (Arfs) by inducing GTP hydrolysis and participate in a diverse array of cellular functions both through mechanisms that are dependent on and independent of their Ar... see more
Hansheng Li, Yumeng Lyu, Xiaohui Chen, Congqiao Wang, Deheng Yao, Shanshan Ni, Yuling Lin, Yukun Chen, Zihao Zhang and Zhongxiong Lai
Light is an important factor that affects the synthesis of functional metabolites in longan embryogenic calli (ECs). However, analysis of the effect of light on functional metabolites in longan ECs via RNA sequencing has rarely been reported and their lig... see more
Min Lu
Integral membrane proteins of the divalent anion/Na+ symporter (DASS) family are conserved from bacteria to humans. DASS proteins typically mediate the coupled uptake of Na+ ions and dicarboxylate, tricarboxylate, or sulfate. Since the substrates for DASS... see more
Yanna Gurianov, Faina Nakonechny, Yael Albo and Marina Nisnevitch
Alejandra Chávez-Carbajal, Khemlal Nirmalkar, Ana Pérez-Lizaur, Fernando Hernández-Quiroz, Silvia Ramírez-del-Alto, Jaime García-Mena and César Hernández-Guerrero
Obesity is an excessive fat accumulation that could lead to complications like metabolic syndrome. There are reports on gut microbiota and metabolic syndrome in relation to dietary, host genetics, and other environmental factors; however, it is necessary ... see more
Mariya Tsaneva, Kristof De Schutter, Bruno Verstraeten and Els J.M. Van Damme
Johannes Vogel, Cora Sandra Thiel, Svantje Tauber, Christian Stockmann, Max Gassmann and Oliver Ullrich
Immune system deterioration in space represents a major risk, which has to be mitigated for exploration-class missions into the solar system. Altered gravitational forces have been shown to regulate adaptation processes in cells of the immune system, whic... see more
Agata Przekora
The aim of engineering of biomaterials is to fabricate implantable biocompatible scaffold that would accelerate regeneration of the tissue and ideally protect the wound against biodevice-related infections, which may cause prolonged inflammation and bioma... see more
Celeste Caruso Bavisotto, Federica Scalia, Antonella Marino Gammazza, Daniela Carlisi, Fabio Bucchieri, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello and Claudia Campanella
Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central... see more
Jonna Jalanka, Giles Major, Kathryn Murray, Gulzar Singh, Adam Nowak, Caroline Kurtz, Inmaculada Silos-Santiago, Jeffrey M. Johnston, Willem M. de Vos and Robin Spiller
Muhammad Amjad Ali, Mahpara Shahzadi, Adil Zahoor, Abdelfattah A. Dababat, Halil Toktay, Allah Bakhsh, Muhammad Azher Nawaz and Hongjie Li
Cereal cyst nematodes (CCNs) are among the most important nematode pests that limit production of small grain cereals like wheat and barley. These nematodes alone are estimated to reduce production of crops by 10% globally. This necessitates a huge enhanc... see more
Sarah B. Miller, Adam L. Heuberger, Corey D. Broeckling and Courtney E. Jahn
Kenichi Nagase, Momoko Hasegawa, Eri Ayano, Yoshie Maitani and Hideko Kanazawa
Alice Guazzelli, Parisa Meysami, Emyr Bakker, Constantinos Demonacos, Antonio Giordano, Marija Krstic-Demonacos and Luciano Mutti
Federica Logiodice, Letizia Lombardelli, Ornela Kullolli, Herman Haller, Enrico Maggi, Daniel Rukavina and Marie-Pierre Piccinni
Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing ... see more
Makoto Tsuchimochi, Haruka Yamaguchi, Kazuhide Hayama, Yasuo Okada, Tomoyuki Kawase, Takamasa Suzuki, Norio Tsubokawa, Noriaki Wada, Atsushi Ochiai, Satoshi Fujii and Hirofumi Fujii
The accurate detection of lymph node metastases is essential for treatment success in early-stage malignant cancer. Sentinel lymph node (SLN) biopsy is the most effective procedure for detecting small or micrometastases that are undetectable by convention... see more