30 articles in this issue
Chloe J. Peach, Viviane W. Mignone, Maria Augusta Arruda, Diana C. Alcobia, Stephen J. Hill, Laura E. Kilpatrick and Jeanette Woolard
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Vadim Demidchik
Anna Tankiewicz-Kwedlo, Justyna Magdalena Hermanowicz, Krystyna Pawlak, Robert Czarnomysy, Krzysztof Bielawski, Izabela Prokop and Dariusz Pawlak
The Bruton’s tyrosine kinase (BTK) inhibitor LFM-A13 has been widely employed as an antileukemic agent, but applications in solid cancer have been found recently. The compound promotes apoptosis, has an antiproliferative effect, and increases cancer... see more
Junko Masuda, Tsukasa Shigehiro, Takuma Matsumoto, Ayano Satoh, Akifumi Mizutani, Chiho Umemura, Shoki Saito, Mayumi Kijihira, Eiji Takayama, Akimasa Seno, Hiroshi Murakami and Masaharu Seno
T cell-deficient mice such as nude mice are often used to generate tumor xenograft for the development of anticancer agents. However, the functionality of the other immune cells including macrophages, dendritic cells (DCs), and myeloid-derived suppressor ... see more
Pengfei Xu, Yonggong Zhai and Jing Wang
The prevalence of obesity and atherosclerosis has substantially increased worldwide over the past several decades. Peroxisome proliferator-activated receptors (PPARs), as fatty acids sensors, have been therapeutic targets in several human lipid metabolic ... see more
Kentaro Inamura
Chun-Tang Chiou, Kaw-Chen Wang, Ying-Chen Yang, Chuen-Lin Huang, Sien-Hung Yang, Yao-Haur Kuo and Nai-Kuei Huang
Flávia V. Soares, Alexandre A. De Castro, Ander F. Pereira, Daniel H. S. Leal, Daiana T. Mancini, Ondrej Krejcar, Teodorico C. Ramalho, Elaine F. F. Da Cunha and Kamil Kuca
Organophosphorus compounds (OP) are part of a group of compounds that may be hazardous to health. They are called neurotoxic agents because of their action on the nervous system, inhibiting the acetylcholinesterase (AChE) enzyme and resulting in a choline... see more
Raquibul Hasan and Xuming Zhang
Ca2+ signaling influences nearly every aspect of cellular life. Transient receptor potential (TRP) ion channels have emerged as cellular sensors for thermal, chemical and mechanical stimuli and are major contributors to Ca2+ signaling, playing an importan... see more
Shyh-Han Tan, Gyorgy Petrovics and Shiv Srivastava
Yaqi Dou, Shan He, Xu-Fang Liang, Wenjing Cai, Jie Wang, Linjie Shi and Jiao Li
Aya Mizutani Akimoto, Erika Hasuike Niitsu, Kenichi Nagase, Teruo Okano, Hideko Kanazawa and Ryo Yoshida
Elizabeth Kazarian, HyunYoung Son, Paulene Sapao, Wei Li, Zhibing Zhang, Jerome F. Strauss III and Maria E. Teves
Yann Guillermin, Jonathan Lopez, Kaddour Chabane, Sandrine Hayette, Claire Bardel, Gilles Salles, Pierre Sujobert and Sarah Huet
High throughput sequencing (HTS) is increasingly important in determining cancer diagnoses, with subsequent prognostic and therapeutic implications. The biology of cancer is becoming increasingly deciphered and it is clear that therapy needs to be individ... see more
Simona Granata, Gloria Santoro, Valentina Masola, Paola Tomei, Fabio Sallustio, Paola Pontrelli, Matteo Accetturo, Nadia Antonucci, Pierluigi Carratù, Antonio Lupo and Gianluigi Zaza
Muhammad Salman Hameed, Zhengbing Wang, Liette Vasseur and Guang Yang
Man Zhao, Peng Chen, Wenyi Wang, Fengjie Yuan, Danhua Zhu, Zhao Wang and Xiangxian Ying
Jacob Raber, Eileen Ruth S. Torres, Tunde Akinyeke, Joanne Lee, Sydney J. Weber Boutros, Mitchell S. Turker and Amy Kronenberg
The space radiation environment includes helium (4He) ions that may impact brain function. As little is known about the effects of exposures to 4He ions on the brain, we assessed the behavioral and cognitive performance of C57BL/6J × DBA2/J F1 (B6D2... see more
Shike Wang, Zhenyu Li and Ren Xu
Cancer patients experience a four-fold increase in thrombosis risk, indicating that cancer development and progression are associated with platelet activation. Xenograft experiments and transgenic mouse models further demonstrate that platelet activation ... see more
Elzbieta Pawlowska, Joanna Szczepanska, Karol Wisniewski, Paulina Tokarz, Dariusz J. Jaskólski and Janusz Blasiak
The rupture of saccular intracranial aneurysms (IA) is the commonest cause of non-traumatic subarachnoid hemorrhage (SAH)—the most serious form of stroke with a high mortality rate. Aneurysm walls are usually characterized by an active inflammatory ... see more
Rui Li, Yongli Du, Zhipei Gao and Jingkang Shen
Beata Olszewska, Anna Stasiak, Daniel McNaught Flores, Wieslawa Agnieszka Fogel, Rob Leurs and Krzysztof Walczynski
Chien-Feng Li, Kun-Hung Shen, Lan-Hsiang Chien, Cheng-Hao Huang, Ting-Feng Wu and Hong-Lin He
Among various heterogeneous types of bladder tumors, urothelial carcinoma is the most prevalent lesion. Some of the urinary bladder urothelial carcinomas (UBUCs) develop local recurrence and may cause distal invasion. Galectin-1 de-regulation significantl... see more
Maria Trovato, Luciana D’Apice, Antonella Prisco and Piergiuseppe De Berardinis
Since the identification of the Human Immunodeficiency Virus type 1 (HIV-1) as the etiologic agent of AIDS (Acquired Immunodeficiency Syndrome), many efforts have been made to stop the AIDS pandemic. A major success of medical research has been the develo... see more
Changmin Kim, Hyo-Sook Song, Hojung Park and Bonglee Kim
Sakineh Kazemi Noureini, Mitra Kheirabadi, Fatima Masoumi, Farve Khosrogerdi, Younes Zarei, Cristian Suárez-Rozas, Julio Salas-Norambuena and Bruce Kennedy Cassels
Michel Ruiz Rosquete, Sascha Waidmann and Jürgen Kleine-Vehn
Directional growth of lateral roots is critical for radial expansion and soil coverage. Despite its importance, almost nothing is known about its molecular determinants. Initially, young lateral roots (LRs) grow away from the parental root, maintaining th... see more
Ivan V. Maly and Wilma A. Hofmann
Recently, there have been a number of developments in the fields of calcium and nuclear signaling that point to new avenues for a more effective diagnosis and treatment of prostate cancer. An example is the discovery of new classes of molecules involved i... see more
Michaela Frolikova, Pavla Manaskova-Postlerova, Jiri Cerny, Jana Jankovicova, Ondrej Simonik, Alzbeta Pohlova, Petra Secova, Jana Antalikova and Katerina Dvorakova-Hortova
Proteins CD9 and CD81 are members of the tetraspanin superfamily and were detected in mammalian sperm, where they are suspected to form an active tetraspanin web and to participate in sperm–egg membrane fusion. The importance of these two proteins d... see more
Hao Liu, Haifen Li, Jianzhong Gu, Li Deng, Li Ren, Yanbin Hong, Qing Lu, Xiaoping Chen and Xuanqiang Liang