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3.771  Articles
1 of 378 pages  |  10  records  |  more records»
The effect of individual oncogene on diverse cell types could be studied by using transgenic mice. The expression of transgene is mainly determined by the regulatory sequences chosen. Fifty four v-H-ras transgenic FVB/N mice and 54 parental FVB/N mice wer... see more

Myostatin, a transforming growth factor-ß family member, is a negative regulator of skeletal muscle development and growth. Piedmontese cattle breeds have a missense mutation, which results in a cysteine to tyrosine substitution in the mature myostatin pr... see more

Hypertriglyceridemia is a predisposing factor for several metabolic diseases in the worldtoday. Their cause is multifactorial, several factors are directly linked to the modification ofplasma lipid metabolism, among them are genetics and exercise. The gen... see more

B-lymphocytes are considered to play a minimal role in host defense against Leishmania major. In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses a... see more

Stem cells in the adult brain subventricular zone (SVZ) generate new neurons that migrate to the olfactory bulb. About half of the new neurons survive and become functional interneurons. SVZ stem cells are being studied to discover if there are ways to en... see more

Introduction: APP/PS1 double-transgenic mouse models of Alzheimer’s disease (AD), which overexpress mutated forms of the gene for the human amyloid precursor protein (APP) and presenilin 1 (PS1), have provided robust neuropathological hallmarks of an AD-l... see more

To counteract oxidative stress cells developed several mechanisms, including the transcription factor Nuclear Factor E2-related factor 2 (Nrf2). The aim of the study was to evaluate the activation of Nrf2 in transgenic mice fed saturated or polyunsaturate... see more

Cognitive impairment in Alzheimer’s disease (AD) is usually accompanied by synaptic loss in both the hippocampus and neocortex. In the early stage of AD, amyloid ß-induced synapse changes is the main reason, while in the later stage, the accumulation of T... see more

Age-related changes are associated with susceptibility to infection, malignancy, autoimmunity, response to vaccination and wound healing. To investigate the relationship of several pathological phenotypes of allergic inflammation to age, alterations in th... see more

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