30 articles in this issue
Hongmei Yuan, Lijuan Zhao, Wendong Guo, Ying Yu, Lei Tao, Liguo Zhang, Xixia Song, Wengong Huang, Lili Cheng, Jing Chen, Fengzhi Guan, Guangwen Wu and Huiyu Li
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Mian Zhang, Man-Man Fu, Cheng-Wei Qiu, Fangbin Cao, Zhong-Hua Chen, Guoping Zhang and Feibo Wu
Tibetan wild barley has been identified to show large genetic variation and stress tolerance. A genome-wide association (GWA) analysis was performed to detect quantitative trait loci (QTLs) for drought tolerance using 777 Diversity Array Technology (DArT)... see more
Bo Fu, Hong Ma and Di Liu
Pre-implantation embryo development encompasses several key developmental events, especially the activation of zygotic genome activation (ZGA)-related genes. Endogenous retroviruses (ERVs), which are regarded as “deleterious genomic parasites”... see more
Peter Valent, Wolfgang Kern, Gregor Hoermann, Jelena D. Milosevic Feenstra, Karl Sotlar, Michael Pfeilstöcker, Ulrich Germing, Wolfgang R. Sperr, Andreas Reiter, Dominik Wolf, Michel Arock, Torsten Haferlach and Hans-Peter Horny
Tingting Jia, Jian Wang, Wei Chang, Xiaoxu Fan, Xin Sui and Fuqiang Song
Juan Carlos Crespo-Rivas, Pilar Navarro-Gómez, Cynthia Alias-Villegas, Jie Shi, Tao Zhen, Yanbo Niu, Virginia Cuéllar, Javier Moreno, Teresa Cubo, José María Vinardell, José Enrique Ruiz-Sainz, Sebastián Acosta-Jurado and María José Soto
Syed Ammar Hussain, Ahsan Hameed, Md. Ahsanul Kabir Khan, Yao Zhang, Huaiyuan Zhang, Victoriano Garre and Yuanda Song
Dorota Formanowicz, Jacek B. Krawczyk, Bartlomiej Perek and Piotr Formanowicz
We propose a control-theoretic aggregate model of the progression of atherosclerosis plaque, a chronic inflammatory disease of the arterial wall, to study the basic features of this disease. In the model, we exploit the role of inflammation in the disease... see more
Isabelle Opitz and Michaela B. Kirschner
Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a debilitating disease, for which the underlying pathophysiological mechanisms have yet to be fully elucidated. Occurrence of a pulmonary embolism (PE) is a major risk factor for the development of ... see more
Jason A. Wulff, Mahnaz Kiani, Karly Regan, Micky D. Eubanks and Adrianna Szczepaniec
Josué Villegas-Mendoza, Ramón Cajal-Medrano and Helmut Maske
Arnab Dawn
A supramolecular gel is a fascinating combination of flexibility and orderliness. While the supramolecular nature of crosslinking contributes towards the adaptivity and the reversibility of the system, orderliness at the molecular level amplifies the func... see more
Wei Tang, Dongming Lan, Zexin Zhao, Shuang Li, Xiuting Li and Yonghua Wang
Zhiwen Zhou, Yuji Ikegaya and Ryuta Koyama
Astrocytes are major glial cells that play critical roles in brain homeostasis. Abnormalities in astrocytic functions can lead to brain disorders. Astrocytes also respond to injury and disease through gliosis and immune activation, which can be both prote... see more
Belén Callejón-Leblic, Ana Arias-Borrego, Antonio Pereira-Vega, José Luis Gómez-Ariza and Tamara García-Barrera
Carcinogenesis is a very complex process in which metals have been found to be critically involved. In this sense, a disturbed redox status and metal dyshomeostasis take place during the onset and progression of cancer, and it is well-known that trace ele... see more
Renata Lejkowska, Milosz Piotr Kawa, Ewa Pius-Sadowska, Dorota Roginska, Karolina Luczkowska, Boguslaw Machalinski and Anna Machalinska
This study aimed to investigate whether the transplantation of genetically engineered bone marrow-derived mesenchymal stromal cells (MSCs) to overexpress brain-derived neurotrophic factor (BDNF) could rescue the chronic degenerative process of slow retina... see more
Michael J. Thrippleton, Gordon W. Blair, Maria C. Valdes-Hernandez, Andreas Glatz, Scott I. K. Semple, Fergus Doubal, Alex Vesey, Ian Marshall, David E. Newand Joanna M. Wardlaw
Zipeng Yu, Yang Xu, Lin Liu, Yarong Guo, Xisen Yuan, Xinyu Man, Chang Liu, Guodong Yang, Jinguang Huang, Kang Yan, Chengchao Zheng, Changai Wu and Shizhong Zhang
Daniel H.F. Hui, Kevin J. Tam, Ivy Z.F. Jiao and Christopher J. Ong
The semaphorins represent a large family of signaling molecules with crucial roles in neuronal and cardiac development. While normal semaphorin function pertains largely to development, their involvement in malignancy is becoming increasingly evident. One... see more
Huey-Huey Chua, Toshiki Kameyama, Akila Mayeda and Te-Huei Yeh
Walter Bonfig and Reinhard W. Holl
In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both grow... see more
Carmen Vida, Hikaru Kobayashi, Antonio Garrido, Irene Martínez de Toda, Eva Carro, José Antonio Molina and Mónica De la Fuente
In Parkinson’s Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the im... see more
Shahed Taheri, Thomas Winkler, Lia Sabrina Schenk, Carl Neuerburg, Sebastian Felix Baumbach, Jozef Zustin, Wolfgang Lehmann and Arndt F. Schilling
It is widely accepted that the subchondral bone (SCB) plays a crucial role in the physiopathology of osteoarthritis (OA), although its contribution is still debated. Much of the pre-clinical research on the role of SCB is concentrated on comparative evalu... see more
Antonio Garrido, Julia Cruces, Noemí Ceprián, Elena Vara and Mónica de la Fuente
Sandeep Silawal, Maximilian Willauschus, Gundula Schulze-Tanzil, Clemens Gögele, Markus Geßlein and Silke Schwarz
The association between osteoarthritis (OA), obesity and metabolic syndrome suggests an interrelation between OA and diabetes mellitus (DM). Little is known about the role of anti-inflammatory cytokine interleukin (IL)-10 in the interrelation between OA a... see more
Mahmoud Mona, Rehae Miller, Hui Li, Yun-Jong Park, Raafi Zaman, Li-Jun Yang and Seunghee Cha
Sjögren’s syndrome (SjS) is an autoimmune disease that destroys the salivary glands and results in severe dry mouth. Mesenchymal stem cell (MSC) transplantation has been recently proposed as a promising therapy for restoring cells in multiple d... see more
Dietbert Neumann and Benoit Viollet
AMP-activated protein kinase (AMPK) regulates energy homeostasis in eukaryotic cells and organisms [...]
Gaia Favero, Francesca Bonomini, Caterina Franco and Rita Rezzani
Fibromyalgia syndrome (FMS) is considered a musculoskeletal disorder associated to other symptoms including chronic pain. Since the hypothesis of FMS etiogenesis is consistent with mitochondrial dysfunction and oxidative stress, we evaluated the pathophys... see more
Simona Martinotti, Umberto Laforenza, Mauro Patrone, Francesco Moccia and Elia Ranzato
Since Biblical times, honey has been utilized in “folk medicine”, and in recent decades the positive qualities of honey have been re-discovered and are gaining acceptance. Scientific literature states that honey has been successfully utilized ... see more
Saturnino Marco Lupi, Arianna Rodriguez y Baena, Clara Cassinelli, Giorgio Iviglia, Marco Tallarico, Marco Morra and Ruggero Rodriguez y Baena
Biochemical modification of titanium surfaces (BMTiS) entails immobilization of biomolecules to implant surfaces in order to induce specific host responses. This crossover randomized clinical trial assesses clinical success and marginal bone resorption of... see more