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251  Articles
1 of 26 pages  |  10  records  |  more records»
Colorectal carcinoma (CRC) represents a global health problem. The EGFR signaling pathway is very important in the initiation of different human epithelial cancers and plays a key role in colorectal carcinogenesis. Considering the role of EGFR as a mitoge... see more

Introduction: Data on the utilisation of epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs) and their clinical outcomes in a heterogeneous Pakistani-Asian population have not been previously reported. This manuscript presents the fi... see more

Objectives: To compare the clinical effects of Osimertinib and Gefitinib in the treatment of non-small cell lung (NSCLC) complicated with epidermal growth factor receptor (EGFR) gene mutation.Methods: We retrospectively analyzed the clinical data of 102 p... see more

Introduction: Evidence from phase III and the EMPA-REG OUTCOME trials have demonstrated improvements in renal endpoints with empagliflozin use. The EMPA-KIDNEY trial is currently underway and is assessing whether there are benefits of empagliflozin i... see more

The purpose of this study was to investigate the incidence and clinical significance of alterations in EGFR, IGF1R and the cell signaling pathway activities induced by them, as well as EGR1 expression in resected non-small cell lung cancer (NSCLC). The pr... see more

ABSTRACTBackground: Inverted papilloma (IP) is benign tumor of the nasal cavity and paranasal sinuses epithelium. Sinonasal squamous cell carcinoma (SCC) is epithelial malignancy of nasal cavity and paranasal sinuses. HPV increases epidermal growth factor... see more

Epidermal growth factor receptor (EGFR) is one of tyrosine kinase that overexpressed in many types of cancer. The ihbiition of EGFR activity has known as a rational target for cancer therapy. However,  several EGFR inhibitors have limitations related... see more

Erlotinib, Afatinib, and WZ4002 are quinazoline derivative compounds and classified as first, second, and third-generation EGFR inhibitor. All inhibitors have been given directly to cancer patients for many years but find some resistance. These three comp... see more

Lung cancer is one of the malignant diseases mostly caused by tobacco users. EGFR, proto oncogene plays an important role in many biological processes apoptosis, transcriptional regulation, cell differentiation, cell spreading and mobility. The mutation o... see more

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