30 articles in this issue
Jelena Krstic, Markus Galhuber, Tim J. Schulz, Michael Schupp and Andreas Prokesch
Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the m... see more
Jing Jie, Yixin Zhang, Hongyue Zhou, Xiaoyu Zhai, Nannan Zhang, Hongyan Yuan, Weihua Ni and Guixiang Tai
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Hee Kyoung Kang, Moon-Chang Choi, Chang Ho Seo and Yoonkyung Park
Various organisms exist in the oceanic environment. These marine organisms provide an abundant source of potential medicines. Many marine peptides possess anticancer properties, some of which have been evaluated for treatment of human cancer in clinical t... see more
Hüseyin Ilgü, Jean-Marc Jeckelmann, Claire Colas, Zöhre Ucurum, Avner Schlessinger and Dimitrios Fotiadis
Kamila Szymanska, Krystyna Makowska and Slawomir Gonkowski
Bisphenol A, used in the production of plastic, is able to leach from containers into food and cause multidirectional adverse effects in living organisms, including neurodegeneration and metabolic disorders. Knowledge of the impact of BPA on enteric neuro... see more
Longcan Mei, Yanping Zhou, Lizhe Zhu, Changlin Liu, Zhuo Wu, Fangkui Wang, Gefei Hao, Di Yu, Hong Yuan and Yanfang Cui
A superkine variant of interleukin-2 with six site mutations away from the binding interface developed from the yeast display technique has been previously characterized as undergoing a distal structure alteration which is responsible for its super-potenc... see more
Vajira R. Wanniarachchi, Lettee Dametto, Crystal Sweetman, Yuri Shavrukov, David A. Day, Colin L. D. Jenkins and Kathleen L. Soole
Luana Paulesu, Ch.V. Rao, Francesca Ietta, Adalgisa Pietropolli and Carlo Ticconi
Xavier Palomer, Emma Barroso, Javier Pizarro-Delgado, Lucía Peña, Gaia Botteri, Mohammad Zarei, David Aguilar, Marta Montori-Grau and Manuel Vázquez-Carrera
Research in recent years on peroxisome proliferator-activated receptor (PPAR)ß/d indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPARß/d activation might help prev... see more
Yun-Ho Hwang, Kwang-Jin Kim, Su-Jin Kim, Seul-Ki Mun, Seong-Gyeol Hong, Young-Jin Son and Sung-Tae Yee
Osteoporosis is characterized by a reduction of the bone mineral density (BMD) and microarchitectural deterioration of the bone, which lead to bone fragility and susceptibility to fracture. Astaxanthin (AST) has a variety of biological activities, such as... see more
José A Del Campo, Rocío Gallego-Durán, Paloma Gallego and Lourdes Grande
Claudia Cava, Gloria Bertoli, Antonio Colaprico, Gianluca Bontempi, Giancarlo Mauri and Isabella Castiglioni
Matthew W. McCarthy and Thomas J. Walsh
Haruka Yamaguchi, Kazuhide Hayama, Ichiro Sasagawa, Yasuo Okada, Tomoyuki Kawase, Norio Tsubokawa and Makoto Tsuchimochi
We investigated the effects of targeted functionalized silica nanoparticles on the radiosensitivity of cancer cells. Better control of the local concentration of silica nanoparticles may facilitate their use as an adjuvant in conjunction with ionizing rad... see more
Yoon Jin Cha, Eun-Sol Kim and Ja Seung Koo
Amino acid transporters are membrane transport proteins, most of which are members of the solute carrier families. Amino acids are essential for the survival of all types of cells, including tumor cells, which have an increased demand for nutrients to fac... see more
Ewa Kruminis-Kaszkiel, Judyta Juranek, Wojciech Maksymowicz and Joanna Wojtkiewicz
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein-9 nuclease (Cas9) is a genome editing tool that has recently caught enormous attention due to its novelty, feasibility, and affordability. This system natural... see more
Ruud P. M. Dings, Michelle C. Miller, Robert J. Griffin and Kevin H. Mayo
Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting ß-galact... see more
Cameron A. Wade and Natasha Kyprianou
The major challenge in the treatment of patients with advanced lethal prostate cancer is therapeutic resistance to androgen-deprivation therapy (ADT) and chemotherapy. Overriding this resistance requires understanding of the driving mechanisms of the tumo... see more
Se Eun Byeon, Young-Su Yi, Jongsung Lee, Woo Seok Yang, Ji Hye Kim, Jooyoung Kim, Suntaek Hong, Jong-Hoon Kim and Jae Youl Cho
Hydroquinone (HQ, 1,4-benzenediol) is a hydroxylated benzene metabolite with various biological activities, including anti-oxidative, neuroprotective, immunomodulatory, and anti-inflammatory functions. However, the anti-cancer activity of HQ is not well u... see more
Margarita-Maria Panou, Emma L. Prescott, Daniel L. Hurdiss, Gemma Swinscoe, Michael Hollinshead, Laura G. Caller, Ethan L. Morgan, Louisa Carlisle, Marietta Müller, Michelle Antoni, David Kealy, Neil A. Ranson, Colin M. Crump and Andrew Macdonald
BK polyomavirus (BKPyV; hereafter referred to as BK) causes a lifelong chronic infection and is associated with debilitating disease in kidney transplant recipients. Despite its importance, aspects of the virus life cycle remain poorly understood. In addi... see more
Kerstin Göbel, Christoph Kleinschnitz and Sven G. Meuth
Multiple sclerosis (MS) is one of the most emerging fields in neurology[...]
Xue Cao, Qiuqiong Tang, Tim Holland-Letz, Melanie Gündert, Katarina Cuk, Sarah Schott, Jörg Heil, Michael Golatta, Christof Sohn, Andreas Schneeweiss and Barbara Burwinkel
Nanthana Chaiwong, Chanakan Prom-u-thai, Nadia Bouain, Benoit Lacombe and Hatem Rouached
Moo-Kon Song, Byeong-Bae Park and Ji-Eun Uhm
Igor Pottosin, Isaac Zepeda-Jazo, Jayakumar Bose and Sergey Shabala
Oxidative stress signaling is essential for plant adaptation to hostile environments. Previous studies revealed the essentiality of hydroxyl radicals (HO•)-induced activation of massive K+ efflux and a smaller Ca2+ influx as an important component of plan... see more
Ming-yang Wang, Jing-wei Liang, Xin-yang Li, Kamara Mohamed Olounfeh, Shi-long Li, Shan Wang, Lin Wang and Fan-hao Meng
A series of imidazolium salt derivatives have demonstrated potent antitumor activity in prior research. A comprehensive in silicon method was carried out to identify the putative protein target and detailed structure-activity relationship of the compounds... see more
Laura A. Forney, Natalie R. Lenard, Laura K. Stewart and Tara M. Henagan
Chronic inflammation in adipose tissue may contribute to depot-specific adipose tissue expansion, leading to obesity and insulin resistance. Dietary supplementation with quercetin or botanical extracts containing quercetin attenuates high fat diet (HFD)-i... see more
Alain Lescoat, Alice Ballerie, Yu Augagneur, Claudie Morzadec, Laurent Vernhet, Olivier Fardel, Patrick Jégo, Stéphane Jouneau and Valérie Lecureur
Macrophages play a central role in the pathogenesis of inflammatory and fibrotic lung diseases. However, alveolar macrophages (AM) are poorly available in humans to perform in vitro studies due to a limited access to broncho-alveolar lavage (BAL). In this... see more
Juan J. Díez, Susana Sangiao-Alvarellos and Fernando Cordido
Pharmacological treatment of growth hormone deficiency (GHD) in adults began in clinical practice more than 20 years ago. Since then, a great volume of experience has been accumulated on its effects on the symptoms and biochemical alterations that charact... see more
Daniela Caccamo, Sergio Ricca, Monica Currò and Riccardo Ientile
Hypovitaminosis D has become a pandemic, being observed in all ethnicities and age groups worldwide. Environmental factors, such as increased air pollution and reduced ultraviolet B (UVB) irradiation, as well as lifestyle factors, i.e., decreased outdoor ... see more