30 articles in this issue
Dong-Hee Choi and Jongmin Lee
Oxidative stress (OS) is one of the factors that cause dementia conditions such as Alzheimer’s disease and vascular dementia (VaD). In the pathogenesis of VaD, OS is associated with risk factors that include increased age, hypertension, and stroke. Nicoti... see more
Richard Kovács and Wolfram S. Kunz
Epilepsy is a very frequent, severe, and disabling neurological disorder with has a considerable disease burden worldwide [...]
Andrea Borghini, Ilenia Foffa, Silvia Pulignani, Cecilia Vecoli, Lamia Ait-Ali and Maria Grazia Andreassi
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Minsup Lee, Seohyeon Yun, Hyesook Lee and Jaewook Yang
Retinal vascular endothelial growth factor (VEGF) increased by neovascularization is well known as a pathogenic factor in ocular neovascular diseases. However, it is still unclear how retinal neurons are damaged by VEGF. The aims of this study are to demo... see more
Lisa-Maria Schanza, Maximilian Seles, Michael Stotz, Johannes Fosselteder, Georg C. Hutterer, Martin Pichler and Verena Stiegelbauer
Renal cell carcinoma (RCC) are the most common renal neoplasia and can be divided into three main histologic subtypes, among which clear cell RCC is by far the most common form of kidney cancer. Despite substantial advances over the last decade in the und... see more
Hendrik Ungefroren, David Witte, Bernhard H. Rauch, Utz Settmacher, Hendrik Lehnert, Frank Gieseler and Roland Kaufmann
The G protein-coupled receptor proteinase-activated receptor 2 (PAR2) has been implicated in various aspects of cellular physiology including inflammation, obesity and cancer. In cancer, it usually acts as a driver of cancer progression in various tumor t... see more
Choon Sang Bae and Juhyun Song
Alzheimer’s disease (AD), characterized by the aggregation of amyloid-ß (Aß) protein and neuroinflammation, is the most common neurodegenerative disease globally. Previous studies have reported that some AD patients show impaired glucose utilization in br... see more
Adil El Midaoui, Youssef Haddad, Younes Filali-Zegzouti and Réjean Couture
Leilei Zhong, Stefano Schivo, Xiaobin Huang, Jeroen Leijten, Marcel Karperien and Janine N. Post
Interleukin 1 beta (IL1ß) and Wingless-Type MMTV Integration Site Family (WNT) signaling are major players in Osteoarthritis (OA) pathogenesis. Despite having a large functional overlap in OA onset and development, the mechanism of IL1ß and WNT crosstalk ... see more
Marcin Lewandowski and Krzysztof Gwozdzinski
Nitroxides are stable free radicals that contain a nitroxyl group with an unpaired electron. In this paper, we present the properties and application of nitroxides as antioxidants and anticancer drugs. The mostly used nitroxides in biology and medicine ar... see more
Venkata S. Kuppireddy, Vladimir N. Uversky, Su San Toh, Ming-Chang Tsai, William C. Beckerson, Catarina Cahill, Brittany Carman and Michael H. Perlin
Michele Guescini, Serena Maggio, Paola Ceccaroli, Michela Battistelli, Giosuè Annibalini, Giovanni Piccoli, Piero Sestili and Vilberto Stocchi
Myogenic differentiation is triggered, among other situations, in response to muscle damage for regenerative purposes. It has been shown that during myogenic differentiation, myotubes release extracellular vesicles (EVs) which participate in the signallin... see more
Marcella Nunziato, Flavio Starnone, Barbara Lombardo, Matilde Pensabene, Caterina Condello, Francesco Verdesca, Chiara Carlomagno, Sabino De Placido, Lucio Pastore, Francesco Salvatore and Valeria D’Argenio
Magdalena Sustkova-Fiserova, Chrysostomos Charalambous, Tereza Havlickova, Marek Lapka, Pavel Jerabek, Nina Puskina and Kamila Syslova
Cristina Pellegrini, Maria Giovanna Maturo, Lucia Di Nardo, Valeria Ciciarelli, Carlota Gutiérrez García-Rodrigo and Maria Concetta Fargnoli
Run-Zhe Liu, Chao-Xin Fan, Zhi-Lin Zhang, Xin Zhao, Yi Sun, Hui-Hui Liu, Zong-Xiu Nie and Xiao-Ping Pu
Anizah Rahumatullah, Izzati Zahidah Abdul Karim, Rahmah Noordin and Theam Soon Lim
Peggy Reich, Regina Stoltenburg, Beate Strehlitz, Dieter Frense and Dieter Beckmann
Hideaki Obata
Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are used to treat chronic pain, such as neuropathic pain. Why antidepressants are effective for treatment of neuropathic pain and the precise mechanisms underlying their effects, ho... see more
Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Volha V. Zhukouskaya, Silvia Savastano, Chiara Mele, Massimo Scacchi, Gianluca Aimaretti, Annamaria Colao and Paolo Marzullo
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular ... see more
Carla Iacobini, Claudia Blasetti Fantauzzi, Giuseppe Pugliese and Stefano Menini
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate cartilag... see more
Chiung-Mei Chen, Yih-Ru Wu and Kuo-Hsuan Chang
Takashi Kikuchi, Naoki Motoyashiki, Takeshi Yamada, Kanae Shibatani, Kiyofumi Ninomiya, Toshio Morikawa and Reiko Tanaka
Carolina M. Medeiros Da Cunha, Valeria Perugini, Petra Bernegger, Matteo Centola, Andrea Barbero, Anna L. Guildford, Matteo Santin, Andrea Banfi, Ivan Martin and Anna Marsano
Autologous chondrocyte transplantation for cartilage repair still has unsatisfactory clinical outcomes because of inter-donor variability and poor cartilage quality formation. Re-differentiation of monolayer-expanded human chondrocytes is not easy in the ... see more
Young Seok Park, Hui Jeong An, Jung Oh Kim, Won Seop Kim, In Bo Han, Ok Joon Kim, Nam Keun Kim and Dong-Seok Kim
Emma Katengua-Thamahane, Barbara Szeiffova Bacova, Iveta Bernatova, Matus Sykora, Vladimir Knezl, Jacques Van Rooyen and Narcis Tribulova
The purpose of this study was to investigate the effect of antioxidants rich red palm oil (RPO) supplementation on cardiac oxidative stress known as crucial factor deteriorating heart function in hypertension. 3-month-old, male spontaneously hypertensive ... see more
Paulina Carvajal-Vidal, Mireia Mallandrich, María Luisa García and Ana Cristina Calpena
Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers ... see more
Laura Fattorini, Federica Della Rovere, Eleonora Andreini, Marilena Ronzan, Giuseppina Falasca and Maria Maddalena Altamura
Na Zhai, Haihong Jia, Dongdong Liu, Shuchang Liu, Manli Ma, Xingqi Guo and Han Li
Katharina Mueck, Simone Rebholz, Mozhgan Dehghan Harati, H. Peter Rodemann and Mahmoud Toulany
Akt1 is known to promote non-homologous end-joining (NHEJ)-mediated DNA double-strand break (DSB) repair by stimulation of DNA-PKcs. In the present study, we investigated the effect of Akt1 on homologous recombination (HR)-dependent repair of radiation-in... see more