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14  Articles
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The aim of this study was to characterize two monoclonal antibodies (F6A11 and F109-D12) generated against Pdx1 (pancreatic and duodenal homeobox-1), a homeodomain transcription factor, which is critical for pancreas formation as well as for normal pancre... see more

The ability to create patient derived xenografts (PDXs) has evolved considerably from the breakthrough of the development of immune compromised mice. How researchers in drug discovery have utilized PDX of certain cancer types has also changed from traditi... see more

A variety of pancreatic transcription factors including PDX-1 and MafA play crucial roles in the pancreas and function for the maintenance of mature ß-cell function. However, when ß-cells are chronically exposed to hyperglycemia, expression and/or activit... see more

Bone metastasis is a complex process that needs to be better understood in order to help clinicians prevent and treat it. Xenografts using patient-derived material (PDX) rather than cancer cell lines are a novel approach that guarantees more clinically re... see more

<img src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAA/cAAAK7CAYAAAC3a39sAAAAAXNSR0IArs4c6QAAAARnQU1BAACxjwv8YQUAAAAJcEhZcwAADsMAAA7DAcdvqGQAAP+lSURBVHhe7N0HvG1VdS/+bV4SW/K3N6zYEWOJBUus2BFRBEUseAV7RQKCYgERRcQaaywI2FDsRkHBBooFK9gFrEj0vZdX8vL6/s/v4P5O... see more

<img src="data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAA/cAAAK7CAYAAAC3a39sAAAAAXNSR0IArs4c6QAAAARnQU1BAACxjwv8YQUAAAAJcEhZcwAADsMAAA7DAcdvqGQAAP+lSURBVHhe7N0HvG1VdS/+bV4SW/K3N6zYEWOJBUus2BFRBEUseAV7RQKCYgERRcQaaywI2FDsRkHBBooFK9gFrEj0vZdX8vL6/s/v4P5O... see more

This experiment, based on the previous study on R. mori , introduces whole mulberry branch powder into the diet to treat diabetic mice. Mulberry branch bark powder (MBBP) was administered orally to streptozotocin (STZ)-induced type II diabetic (T2D) mice ... see more

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal oncological malignancies in humans. Not-specific symptoms and lack of early diagnostic strategies, frequently lead to late diagnosis which limited therapeutic possibilities (Korc, 2007). Th... see more

Acute myeloid leukaemia (AML) is a rare but severe form of human cancer that results from a limited number of functionally cooperating genetic abnormalities leading to uncontrolled proliferation and impaired differentiation of hematopoietic stem and proge... see more

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