35 articles in this issue
Hai-Yan Lu, Tian-Shu Peng, Xiang-Dang Hu, Shuai-Jun Li, Min Luo, Yong-Heng He, Tian Nie
Cancer accounts as one of the leading causes of morbidity and mortality. Recent studies focus on the efficiency of phytochemicals in cancer therapy. Influence of quercetin, a flavonoid on the effect of ?d T cells and Wnt/ß-catenin signalling pathway in hu... see more
Musaddique Hussain, Shahid Masood Raza, Khalid Hussain Janbaz
In vitro study was carried out to explore the pharmacological basis of crude extract of Buxus wallichiana for its folkloric uses in gastrointestinal, respiratory and vascular disorders. In jejunum preparations, crude extract (0.03 ± 1.0 mg/mL) caused a tr... see more
Meng Hang, Fan Zhao, Shu-Bo Chen, Qing Sun, Chun-Xiao Zhang
The present study was done to determine whether kaempferol, a natural polyphenol of the flavonoid family, affects Epithelial-Mesenchymal Transition (EMT) in non-small cell lung cancer cells. Kaempferol not only inhibited cancer cell proliferation and migr... see more
Wei-Guo Li, He-Qun Wang
A series of novel thiazolidinedione analogues (TZD) were designed and synthesized potent inhibitors of HBV capsid assembly. The synthesis of thiazolidine-2,4-dione derivatives (4a4o), starting from the condensation of 5-(ethoxymethylene)thiazolidine-2,4-d... see more
Zhan-Ying Wang, Wen-Qiong Liu, Si'e Wang, Zeng-Tao Wei
Endometrial cancer is one of the most prevalent gynaecological malignancies where, currently available therapeutic options remain limited. Recently phytochemicals are exploited for their efficiency in cancer therapy. The present study investigates the ant... see more
Jian Zhong, Jian-Quan Hou
The present study was performed to investigate the effect of retinoic acid fluoro chalcone (RAFC) on lipopolysaccharide (LPS) induced epithelial-mesenchymal transition (EMT) in PC3 and CWR22rv1 prostate cell lines. Lipo-polysaccharide (LPS) was used to in... see more
Randhir K. Gupta, Anurag Mishra
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Khalid Hussain Janbaz, Fatima Saqib
Crude extract of Dactylotenium aegyptium and its fractions were evaluated to rationalize its folkloric use in gastrointestinal ailments. In spontaneous contracting rabbit jejunum preparation, D. aegyptium exert concentration-dependent spasmogenic effect (... see more
Narendranath Alluri, Mala Majumdar
The aim of the present study was to investigate the anticancer activity of Drimia nagarjunae (Liliaceae) extracts against Colo205 human colon cancer cell lines by SRB assay for the first time. The bulbs and leaves of the plant were sequentially extracted ... see more
Mao-Chuan Fan, Guang-Ye Han, Xin-Jun Zhang, Hui-Fang Xi
This study was aimed to evaluate anticancer potential of newer synthesize 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines and its derivatives. All newly furnished scaffolds were subjected to screening for their in vitro anticancer potential against DU-145 and PC... see more
Arif Khan, Rahmat Ali Khan, Mushtaq Ahmed, Nadia Mushtaq
Present study is aimed at the pharmacological characterization of methanol extract of Calligonum polygonoides from District Bannu. Dried plant was grounded and extracted with methanol to prepare methanol crud extract. In vitro biological assays were condu... see more
Kerem Canli, Ergin Murat Altuner, Ilgaz Akata
Many plants contain active substances that are known to be effective in both enhancing the wound healing process and lowering the incidence of wound infections. Previous studies have shown that bryophytes produce a variety of secondary metabolites that pr... see more
Emordi Jonathan Emeka, Agbaje Esther Oluwatoyin, Oreagba Ibrahim Adekunle, Iribhogbe Osede Ignis
The purpose of this study is to evaluate the hypoglycaemic properties and preliminary phytochemical screening of Uveria chamae. The hypoglycaemic properties of Uveria chamae was assessed on normoglycaemic rat that received single dose of the extract at 25... see more
Mohammad Shoaib, Ghawsur Rahman, Syed Wadood Ali Shah, Mohammad Naveed Umar
The work was aimed to synthesize 4-Aminoantipyrine derived Schiff bases in economical way and to screen it for study the effect of nitro group on its antibacterial potential, conduct antitumor preliminary study, the effects of group presence in benzyliden... see more
Vivek K. Bajpai, Ajay Sharma, Kwang-Hyun Baek
This study was aimed to evaluate antimicrobial mode of action of Ginkgo biloba leaf essential oil against foodborne pathogenic bacteria. Gas-chromatography and mass-spectrometric analysis determined 34 different compounds, representing 95.45% of the total... see more
Qi-Long Yu, Zhao-Chun Tang, Jin-Ge Li, Guo-Liang Wang; Pei-Jun Wang; Zhao-Bao Pan
This study was aimed to evaluate the chemical composition of ethanolic leaf extract of a marine macro-alga Sargassum wightii (ELESW) followed by its vascular endothelial growth factor (VEGF) induced anti-angiogenic effect against human umbilical vein endo... see more
Yan Jia, Zan-Hui Jia, Jun Chen, He Zhu, Man-Hua Cui
In the present study, the effect of ursolic acid benzaldehyde chalcone (UABC) on ovarian carcinoma cells was studied. The results revealed that ovarian carcinoma cells on UABC treatment increased Sub-G1 cell population, increased rate of cell apoptosis an... see more
Feng Lin, Yu-Hua Peng, Qing-He Yang, Xiu-Ju Mi
Cadmium, a toxic environmental contaminant, induces oxidative stress leading to various neurodegenerative disorders, where it interferes with homeos-tasis of intracellular free calcium ([Ca2+]i), leading to cellular damage and apoptosis. We investigated w... see more
Wu-Jing Zhang, Ying-Bin Zhu, Guo-Dong Zhang
Among numerous established in human hepatoma cell lines, none has been shown susceptible to hepatitis E virus (HEV) infection. Differentiation and infect ability are maintained but when these cells are cultured in the presence of corticoids and dimethyl s... see more
Yanping Shui, Youmei Tang, Xuefeng Zhang, Jun Ge, Zhichen Pu
To evaluate the effectiveness and safety of adjuvant chemotherapy of megestrol acetate (MA) in advanced breast cancer, we searched CBM, CNKI, VIP, Wangfang Data and PubMed, and collected randomized controlled trials (RCT) of adjuvant chemotherapy of MA in... see more
Liaqat Hussain, Muhammad Sajid Hamid Akash, Madeha Tahir, Kanwal Rehman
Sapium sebiferum leaves were used to determine its hepatoprotective effects against paracetamol-induced hepatotoxicity in mice. A dose dependent study was conducted using two different doses (200 mg/kg and 400 mg/kg) of the extract of S. sebiferum&nb... see more
Bhawna Sharma, Isha Dhamija, Sandeep Kumar, Hema Chaudhary
The herb of importance like Argyreia nervosa has shown wide range of pharmacological activities. Its methanolic extract of A. nervosa has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors... see more
Jing lv, Ming-Qin Cao, Jian-Chun Yu
The aim of the current study was to evaluate the anticancer and apoptotic effects of alantolactone pyrazoline analogue in human non-small cell lung cancer (NCI-H460) cells. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetra-zolium bromide) assay was used... see more
Arif Khan, Rahmat Ali Khan, Tanzila Khalil
Oluwakemi K. Sobiyi, A. O. Tom Ashafa
The anthelmintic potential of Heliotropium indicum, Senna fistula and Spigelia anthelmia were investigated using nematodes larvae from sheep and adult earthworms in order to justify the folkloric claim of the plants as worm expeller in south west of Niger... see more
Arushdeep Sidana, Umar Farooq
The present study was aimed at in vitro antileishmanial screening of ten plants used in the traditional medicine in India. MTT method was used to evaluate the cell death after application of 100, 250, 350 and 500 ?g/mL of the methanolic extracts followed ... see more
Issac Paul, Ravi Mundugaru, Narayana Prakash, Ravishankar Basavaiah
Sohaib Mushtaq, Mueen Ahmad Chaudhry, Hafiz Muhammad Abdul Rahman
Abies pindrow is widely used in traditional practice for the treatment of diarrhea and bronchitis and the present study was designed to validate its folkloric uses. The crude extract of A. pindrow inhibit spontaneously contracting (1-10 mg/mL) and high K+... see more
Sammia Shahid, Tauheeda Riaz, Muhammad Nadeem Asghar
Enzyme inhibition potential of various fractions of Ranunculus sceleratus was checked against ?-glucosidase, butyrylcholinesterase, acetylcholinesterase and lipoxygenase enzymes. n-Butanol fraction showed very good activity (77.5 ± 1.0% inhibition at 0.1 ... see more
Fiaz Alam, Qazi Najam us Saqib, Abdul Waheed
This study was conducted to evaluate Gaultheria trichophylla crude extract and respective saponins fraction against human breast cancer cell lines. In MTT assay, cell viability was inhibited by G. trichophylla crude extract (500 µg/mL) and saponins (200 µ... see more
Fatima Saqib, Khalid Hussain Janbaz, Maryam Khan Sherwani
In the current study, methanol extract of Celosia argentea var. cristata was tested for its inhibitory potential against tyrosinase, acetylcholinesterase and butyrylcholinesterase enzymes at the concentration of 0.5 mM by ELISA microtiter plate assays. A ... see more
Jian-Bo Zhou, Gang Peng, Yu-Cheng Jia, Jun Li, Jia Wang, Shu Nie, Qiu-Ying Zhang
The present study demonstrates the effects of triptolide, one of the constituents from Tripterygium wilfordii, on the self-renewal capacity of human hepatocellular carcinoma. The investigation revealed that triptolide markedly prevented the proliferation ... see more
Ponnusamy Revathi, Thangaraj Parimelazhagan
Assessing the antidiabetic potential of Acalypha alnifolia is the main objective of the present study. Two doses of leaf extracts were treated with streptozotocin-induced diabetic rats for 21 days. The glucose level, insulin level, plasma lipids, total pr... see more
Mohammad Saleem, Faiza Naseer, Khalid Hussain, - Alamgeer
In the present study, we examined the cytotoxic effect of Conyza bonariensis (methanolic extract). The skin carcinogenesis was induced in two stages, first, applying tumor initiator, 7-12-dimethyl benz(a)antheracene and thereafter applying croton oil, a t... see more
Irfan Ahmad Rather, Kwang-Ho Choi, Vivek K. Bajpai, Yong-Ha Park
The development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drug... see more