31 articles in this issue
Meng Lv, Xue Tao Wang, Kun Li, Yue Lan Wang
The advents of how anesthesia works have helped in the discovery of anesthetic target protein. One such target protein named ?-aminobutyric acid (GABAA), which is the chief inhibitory neurotransmitter in the mammalian central nervous system. Asparagine at... see more
Purushothaman K. Arun, Sivarathri S. Rajesh, Sankaranarayanan M. Sundaram, Thirunavukkarasu Sivaraman, Pemiah Brindha
LC/ESI/MS/MS data analysis on the phytoconstituents of methanolic extract of Jatropha tanjorensis leaves revealed the presence of abundant flavone glucosides (homoorientin, kaempferol-3-o-rutinoside, luteolin-7-o-glucoside, 6-C-pentosyl-8-C-hexosyl apigen... see more
Qiang Fu, Zhi-Yu Gao, Jie Zhang, Han-Yu Sun, Chao Liu, Jin-Hong Ren
2(E)-2-[1-(4-pyridinyl)ethylidene]hydrazinecarbothioammidehydrochloride (1) and two of its copper complexes were synthesized and structurally characterized. Cu(I) polymeric complex {[Cu(SCN)(3-Acpy)2]}n (2) was synthesized by in situ mixing of Cu(BF4)2.6H... see more
Satyajit Dutta, Supratim Ray, K. Nagarajan
In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid bis amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic ... see more
Ravi Mundugaru, Madhan Chakkravarthy, Ravishankar Basavaiah
The objective of this study was to explore the hepatoprotective activity of fruits of Garcinia pedunculata in paracetamol-induced liver toxicity in rats. Paracetamol-induced hepatotoxicity was evaluated by an increase in serum transaminases and alkaline p... see more
Li Na Song, Ling Xia Li, Qing Hong Shi, Ling Fang, Li Sun, Hai Feng Zhao, Ning Liu, Hong Jun Li, Cheng Yan He
The expression of periostin in the tissue of colorectal cancer patients and its correlation with clinical features were studied. Periostin expression was ~4 fold up-regulated in cancer tissues compared to adjacent non-cancerous tissues. Serum levels of pe... see more
Muhammad Imran Qadir, Muhammad Ali, Zubair Ibrahim
Plants are screened for treatment of many ailments including cancer because they possess certain potential constituents which are effective for treatment. The aim of this study was to evaluate the anticancer activity of Morus nigra leaves against human ce... see more
Antonyraj Selva Prabhu, Gnanakkan Ananthan
Extracts of ten selected ascidians with a reputation of usefulness in treating diabetes were examined for alpha-amylase inhibition using an in vitro model. The extract with the highest activity was selected for further characterization. From the results e... see more
Hai Chen, Xiao-Dong Qi, Ping Qiu
A novel method for the synthesis of aurones from benzofuran-3(2H)-one by condensation with aromatic aldehydes is described. The anticancer activity of the synthesized compounds was evaluated by MTT assay and among the series of 15 compounds, (Z)-2-(4-meth... see more
Mohammad Saleem, Faiza Naseer
Hepatic dysfunction is globally a major health catastrophe that challenges the health care professionals. The existing synthetic drugs to treat liver diseases have not given much pronounced outcomes. So, conventional herbal plants have become progressivel... see more
Syahriel Abdullah, Januarius Gobilik, Khim-Phin Chong
DOI: http://dx.doi.org/10.3329/bjp.v9i4.20616
Liaqat Hussain, Muhammad Imran Qadir, Shafiq-ur- Rehman
The anti-hyperglycemic, anti-hyperlipidemic, kidney and hepatoprotective potential of Caesalpinia decapetala were evaluated in alloxan-induced diabetic rabbits. The plant extract showed concentration dependant significant (p<0.001) therapeutic potentia... see more
Jun Chen, Ye Wang, Wei-Xin Shi
Osteosarcoma is one of the most common malignant bone tumors in children and adults. Till this date, molecular mechanism behind the growth and invasiveness of osteosarcoma is poorly understood. Wnt5a plays an important role in the oncogenesis and cancer m... see more
Bin Ren, Chong Liu, Li-Hua Wu, Peng Jin, Ping Li, Yu-Jie Liu, Qing-Bo Yu
Aberrations in SMAD signaling have been widely associated with colon cancer progression. However, their significance in modulating drug response remains unknown. In this study we investigated the response of chemotherapeutic drugs in colon cancer cells th... see more
Bilal Ahmed, Usman Ali Ashfaq, Muhammad Tahir ul Qamar, Matloob Ahmad
Breast cancer malignancy is prevailing among the women not only from the developing countries but also from the developed one at the rate of 18% of total population worldwide. One of the main causes of breast cancer is estrogen receptor alpha. Overexpress... see more
Solomon O. Rotimi, Oluwakemi Anuoluwapo Rotimi, Olawole O. Obembe
NF-?B controls cellular growth properties of cells and its regulation is key to the management of disease like cancer. Although plant-derived bioactives have been reported to inhibit NF-?B, there is limited knowledge on the interactions between the phytoc... see more
Guo-Fang Guan, De-Jun Zhang, Ding Xin, Lian-Ji Wen, Duo-Jiao Yu, Yan-Qing Lu, Yan Zhao, Tie-Jun Wang
Activation of Notch signaling pathway in cancer stem cells plays a crucial role in the regulation of selfrenewal and maintenance of side population cells. In the present study, we have identified cancer stem like 2.7% side population cells from naso... see more
Pallerla Praneetha, Vanapatla Swaroopa Rani, Yellu Narasimha Reddy, Bobbala Ravi Kumar
Lindernia ciliata is traditionally used in the treatment of jaundice. In the present study, the methanolic extract of L. ciliata was evaluated for its hepatoprotective activity in paracetamol, ethanol and D-galactosamine intoxicated rats. The activity of ... see more
Nighat Fatima, Abida Kalsoom, Amara Mumtaz, Syed Aun Muhammad
The existing aromatase inhibitors produced unwelcome effects impose the discovery of novel drugs with privileged selectivity, a reduced amount of toxicity and humanizing potency. In this study, we illuminate the binding mode of polyketide azaphilanoid pig... see more
Yun-Fei Shuai, Meng-Qing Wang, Le-Qin Xiong, Lin Liu, Yin-He Luo, Tian-Shu Peng
Developmental abnormalities, neuronal apoptosis and associated cognitive impairment following isoflurane exposure in neonatal rodents have been reported. The study was undertaken to investigate the effect of vitamin C supplementation against isoflurane-in... see more
Syed Safiullah Ghori, Mohib Khan, Shaikh Abdul Rahman
The present study was undertaken to investigate hepatoprotective activity of Ficus dalhousiae leaves ethanolic extract based on its traditional claim. Paracetamol- and carbon tetrachloride-induced hepatotoxicity in albino Wistar rats, experimental models ... see more
Azhar Rasul, Xiaoyan Shen, Bingyu Wang, Bao Liu, Xiaomeng Li, Jilin Tang
Tubeimoside-1 (TBMS1) is a triterpenoid saponin with potent anticancer properties. In this study, for the first, we examined the anti-proliferative effects of TBMS1 in human bladder cancer T24 cells and its ability to induce apoptosis and cell cycle arres... see more
V. Balamurugan, Veluchamy Balakrishnan, J. Philip Robinson, M. Ramakrishnan
The objective of the present investigation is focused on the anticancer activity of the ethanolic crude extract of Moringa concanensis leaf and bark against HepG2 cell line. The study was facilitated by collecting the plant sample and subjected to ethanol... see more
Singumsetty Vinay, Shaik Karimulla, Devarajan Saravanan
The purpose of the present study was investigating the GC-MS analysis, preliminary phytochemical screening, physicochemical analysis and anti-diabetic activity of ethanol extract of the leaves of Jasminum cuspidatum. The anti-diabetic activity was investi... see more
Musaddique Hussain, Shahid Masood Raza, Khalid Hussain Janbaz
Crude extract of Oligochaeta ramosa and its fractions were studied to rationalize its traditional use in GIT disturbance. In spontaneous contracting jejunum preparation, O. ramosa (0.01-1.0 mg/mL) caused a transient spasmogenic effect followed by the spas... see more
Sridhar Nimmakayala, Suguna Lakshmi Duggirala, Goverdhan Puchchakayala
Agar well diffusion method was used to evaluate the antimicrobial potential of Justicia neesii extract. The maximum activity index (AI) values are observed against Klebsiella pneumonia (1.208) and low AI value for Streptococcus faecalis (0.963) comp... see more
Varalakshmi Kilingar Nadumane, Bibechana Timsina
Banana (Musa paradisiaca) flower is rich in phytochemicals (vitamins, flavonoids, proteins) and has antioxidant properties. The anti-cancer activity of banana flower extract has been evaluated on the cervical cancer cell line HeLa. The antiproliferative e... see more
Khalid Hussain Janbaz, Arham Shabbir, Malik Hassan Mehmood, Anwarul Hassan Gilani
This study was aimed at providing the pharmacological basis for the medicinal use of Rhus coriaria in diarrhea. In mice, the crude of R. coriaria demonstrated antisecretory and antidiarrheal effects against castor oil-induced fluid accumulation and diarrh... see more
Hui Shi, Yan Xiao Long, Yi Zhang, Ming Zhong, Kuang Zheng
In the present study, fluorophenyl retinoic acid triazole, a retinoic acid derivative having more bioavailability compared to the parent retinoic acid was investigated against cell growth and proliferation. The results indicated that fluorophenyl retinoic... see more
Zhichen Pu, Xiaolong Yuan, Xuefeng Zhang, Qun Chen, Haitang Xie
Literatures about case-control study on the association between CYP2D6*10 gene polymorphism and breast cancer were searched from last updated on May, 2014. Odds ratio of CYP2D6*10 gene distributions in breast cancer patients against healthy control were a... see more
Isha Dhamija, Nitesh Kumar, K.S.R. Pai, M. Manjunath Setty, Sandeep Kumar, Asim K. Jana
DOI: http://dx.doi.org/10.3329/bjp.v9i4.21165