11 articles in this issue
Fazal Ur Rehman, Muhammad Faird Khan, Inamullah Khan, - Roohullah
Acetylcholinesterase (AChE) inhibitors are well established therapeutic agents for clinical management of Alzheimer's Diseases and other disorders associated with deficient cholinergic neurotransmission. In the current investigation, a new inhibitor has b... see more
Bingshu He, Jun Wang
As a complementary therapeutic approach, soy ingredients, such as soy protein and soybean unsaponifiables, recently attract more attention for relieving symptoms of osteoarthritis (OA). Semen sojae germinatum (SSG) processed from bean-... see more
Oyetunji T. Kolawole, Musbau A. Akanji
In this study, the effect of ethanol extract of the leaves of Newbouldia laevis on the activity of a-amylase and a-glucosidase was investigated. Inhibitory effect of N. laevis extract on a-glucosidase was tested in vitro using baker's yeast a-glucosidase ... see more
Jalil Ur Rehman, Najam Us Saqib, Naveed Akhtar, Muhammad Jamshaid, Hafiz Muhammad Asif, Sabira Sultana, Riaz Ur Rehman
In the present study, we evaluated the protective effects of the aqueous-methanolic extract of Suaeda fruticosa (500 mg/kg and 750 mg/kg b.w., p.o) against paracetamol-induced hepatotoxicity in rabbits. Silymarin 100 mg/kg, p.o. was served as standa... see more
K. Sreevishnupriya, Ramalingar Rajasekaran
The most detrimental missense mutations of angiogenin causing Amyotrophic lateral sclerosis were identified computationally and the substrate binding efficiencies of these mutations were also analyzed. Out of 12 variants, I-Mutant 2.0, SIFT and PolyPhen p... see more
Piyush Choudhary, Juhee Singh, V. Karthick, V. Shanthi, R. Rajasekaran, Karuppasamy Ramanathan
The computational identification of missense mutation in CST3 (CYSTATIN 3 or CYSTATIN C) gene has been done in the present study. The missense mutations in the CST3 gene will leads to hereditary cerebral amyloid angiopathy The initiation of the anal... see more
Thirunavukkarasu Sivaraman, Sivarathri Siva Rajesh, Veerayan Elango
Detoxification effect of aqueous, methanol and petroleum ether extracts of medicinal plants such as Aristolochia bracteolata, Mucuna pruriens, Prosopis cineraria and Rauvolfia tetraphylla was systematically screened against lethality of crude venom of Naj... see more
Asadul M. Helali, James McLay, Isa Naina Mohamed
Statins are highly effective in managing hypercholesterolaemia in patients with or without chronic heart disease due to extensive evidence for safety, efficacy and cost effectiveness. Observational cross sectional retrospective cohort study was done in ap... see more
Muhammad Abdullah Shah, Syed Muhammad Abdullah, Muhammad Azim Khan, Hazrat Amin, . Roohullah
Discovery of new cyclooxygenase-2(COX-2) inhibitors is a major area in anti-inflammatory drug discovery. Cannabigerol is a cannabinoid, which is recently discovered as a new COX-2 inhibitor. So far no work has been done to explore in depth mechanistic ins... see more
Zheng-Gang Guo, Xiao-Pen Jia, Xiao-Jun Su, Ping Li, Jian-Hua Hao
Gastrodia elata Blume (Orchidaceae) is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the potential analgesic effect of its active component, gastrodin, has not been systematically studied. This work described... see more
Shenghua Li, Junying Zeng, Juan Tan, Jian Zhang, Qifan Wu, Lingpeng Wang, Xianjin Wu
The present study aims to investigate the hepatoprotective and antioxidant effects of the total flavonoid of Lithocarpus polystachyus Rehd.(LP-F) in vitro and in vivo. The in vitro anti-oxidant property of total flavonoids was investigated by employing va... see more