28 articles in this issue
Mengli Zheng, Naikang Zhou, Lianjun Ma, Wenbo Jin
Our objective was to evaluate an open-label, multicenter, single-arm study to appraise whether amrubicin therapy improves patients with refractory small-cell lung cancer in Chinese clinical study. Patients (n=95) with refractory small-cell lung cancer rec... see more
Maruthamuthu Vijayalakshmi, Kandasamy Ruckmani
The ferric reducing anti-oxidant power (FRAP) assay involved the following steps: a) preparation of samples, b) reactions and c) finally measuring absorbance of sample and standard at 700 nm using spectrophotometer. The samples were methanolic extra... see more
Vivek K. Bajpai, Rajib Majumder, Irfan A. Rather, Kangmin Kim
Lactic acid bacteria are classified Generally Recognized As Safe (GRAS) with most effective potential to divert significant amount of fermentable sugars towards the biosynthesis of functional exopolysaccharide. Exopolysaccharides from lactic acid bacteria... see more
Burçin Ergene Öz, Mert Ilhan, Serkan Ozbilgin, Esra Küpeli Akkol, Özlem Bahadir Acikara, Gülçin Saltan, Hikmet Keles, Ipek Süntar
Alchemilla mollis, is used in traditional medicine for the treatment of wounds and excessive menstruation. Aqueous methanol extracts of A. mollis and A. persica were evaluated for wound healing acivity by using linear incision and circular excision wound ... see more
Nayyab Rafique, Taous Khan, Abdul Jabbar Shah
This study was aimed to explore the pharmacological basis of potential medicinal use of Elaeagnus umbellata in gut disorders. Crude extract of E. umbellata, which was found positive for flavonoids, terpenoids and tannins, provided 9.9-71.9% protection in ... see more
Marimuthu Krishnaveni, Kathiresan Suresh, Ramu Arunkumar
The present study evaluated the anti-proliferative and apoptotic effect of quinine on oral cancer cells Hep-2 and KB. Cell inhibition, apoptosis and anti-inflammatory effects were explored by nuclear DNA cleavage, condensation, change in membrane po... see more
Huma Waqar, Humaira Majeed Khan, Aftab Ahmad Anjum
Epilepsy is an abnormality of nervous system showing seizures. Despite, the known antiepileptic activity of plants possessing anti-oxidant properties, Silybum marianum has not been studied yet. Therefore, present experiment was planned to evaluate antiepi... see more
Kang-Ho Choi, Hong Hyeonju, Irfan A. Rather
Ulcerative colitis is one of the chronic diseases that results in inflammation of colon in humans. In this Visual experiment we demonstrate the histopathology of TNBS induced colitis model of mouse. The experiment involves following steps: a) Selection of... see more
Jun-Xia Sun, Yan Yan, Jian-Hong Xia, Li-Qing Zhou
The present study was aimed to investigate the effect of bryostatin I on the expression of synuclein-A in breast cancer cells. Western blot analysis showed a significant (p<0.005) reduction in the expression of synuclein-A from a concentration of 20 µM... see more
Nazia Tabassum, Alamgeer ., Abdul Aziz, Bashir Ahmad
The present study was aimed to evaluate the effect of Teucrium stocksianum on angiogenesis by using chorioallantoic membrane (CAM) assay. Fertilized eggs were incubated on the 5th day and dose of different dilutions 0.03%, 0.05%, 0.1%, and 0.5% of the pla... see more
Shruti Shukla
Aflatoxin are potentially toxic metabolites produced by microscopic fungi when grow on food. Hence, determining content of mycotoxins such as aflatoxin has significant pharmaceutical value. This study reports step-by-step visual demonstration of determina... see more
Kannan Mohan, Muthusamy Padmanaban, Venkatachalam Uthayakumar, Ramachandran Chandrasekhar, Thirunavukkarasu Muralisankar
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Sumeet Gupta, Priyanaka Kashyap, Mohammed Asad, Ipshita Chattopadhyaya, Randhir Dahiya
The present study assesses the protective effect of Nyctanthes arbor-tristis (Nyctaginaceae) extracts and in combination with fluoxetine on stress-induced depression in mice. Leaves were extracted using different solvents (petroleum ether, chloroform and ... see more
Lin Bai, Hui Wang, Luo-Ying Zhang, Ai-Hua Wang, Jie Bai
In the present study, the effect of ludartin on OVCAR5 ovarian carcinoma cells was investigated. MTT cell assay was used for the analysis of cell viability and wound healing assay for migration potential. Results revealed that ludartin treatment at 10 and... see more
Xiao-Yan Xu, Hui-Rui Wang, Shu-Li Guo, Bo Li, Tao Lv
The primary objective of the current investigation was to study the anti-tumor effects of 5-methoxyhydnocarpin in THP-1 human leukemia cells along with evaluating its effects on apoptotic induction, cancer cell migration and cell cycle phase distribution.... see more
Hee Jeong Eom, Yong Joo Park, Hee Rae Kang, Ha Ryong Kim, In Jae Bang, Hyun Bong Park, Kyu Hyuck Chung, Ki Hyun Kim
Sphagnum palustre (a moss) has been traditionally used in Korea for the cure of several diseases such as cardiac pain and stroke. In this research, the inhibitory effect of S. palustre on aromatase (cytochrome P450 19, CYP19) activity was studied. [1?-3H]... see more
Maroua Akacha, Karima Lahbib, Mejda Daami-Remadi, Néziha Ghanem Boughanmi
The aim of the present study is to examine the antibacterial, antifungal and anti-inflammatory activities of the ethanolic leaf extract of Melia azedarach. It was tested in vitro for its antibacterial and antifungal activities against E. coli (ATCC 8739),... see more
Najmeh Kabiri, Mahbubeh Setorki
The aim of study was to investigate the potential neuroprotective effects of Kombucha on cerebral damage induced by ischemia in rats (n=99). Cerebral infarct volume in the ischemic rats received Kombucha solution showed no significance alteration. However... see more
Shuai Zhang, Zong-Fei Jiang, Qiang Pan, Chun-Yu Song, Wen-Hua Zhang
The aim of the current study was to investigate the in vitro and in vivo anti-tumor effects of naringenin chalcone in U87MG human glioblastoma cells and in xenograft mice model. The effect of naringenin chalcone on apoptosis induction was assessed by fluo... see more
Yan Cui, Hui Ren, Hao-Chang Li, Quan-Shi Wang
The aim of the present study was to evaluate the antitumor and anti-angiogenic effects of artemisinic acid in MCF-7 human breast cancer cells. Various cell signalling pathways (VEGF, m-TOR and AKT signalling pathways) and MTT assay were used. The in vivo ... see more
Meilinah Hidayat, Sijani Prahastuti, Nurul Fauziah, Maesaroh Maesaroh, Balqis Balqis, Wahyu Widowati
In this study, we evaluated the effects of ethanol extracts of Detam 1 soybean, Jati belanda leaf, and the combination toward expression of peroxisome proliferator-activated receptor gamma (PPAR?), CCAAT/enhancer-binding protein alpha (C/EBP?), and s... see more
Nasiara Karim, Rahat Ullah, Imran Khan, Muslim Raza, Abdur Rauf, Syed M. Hizbullah, Inam Ullah
Li-Na Zhao, Li-Bo Chen, Xiu-Hua Hao, Zhang Hu, Jing Zhang, Chun-Hai Zhang
In the present study, effects of floroquinone on anaplastic thyroid cancer cell lines and mouse tumor xenografts were investigated. Increase in the concentration of floroquinone from 10 to 100 µM reduced the cell growth from 98 to 17% after 48 hours in HO... see more
Zahra Rabiei, Mostafa Gholami, Mahmoud Rafieian-Kopaei
The aim of this study is to investigate the antidepressant effects of Mentha pulegium essential oil in BALB/c mice. Six experimental groups (7 mice each) were used. Forced swim test was performed 30 min after essential oil injection. In the groups receivi... see more
Olayinka Oyewale Ajani, Damilola Victoria Aderohunmu, Ejike Nzube Umeokoro, Ayodele Ojo Olomieja
This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic tar... see more
Md. Ashraf Ahmad, Mir Misbahuddin, Sharmeen Ahmed
Chronic exposure to high concentration of arsenic caused an increase in the colony count of Bacteroides fragilis in the feces in comparison to healthy volunteer (3.6 × 10¹¹ ± 1.9 vs 1.5 × 10¹¹ ± 1.7 CFU/g of feces) which was not statistically significant.... see more
Ana Damjanovic Damjanovic, Gordana Zdunic, Katarina Savikin, Boris Mandic, Milka Jadranin, Ivana Z. Matic, Tatjana P. Stanojkovic
The cytotoxicity of Mahonia aquifolium ethanol and water extracts was examined using MTT test. The morphological changes were analyzed by fluorescence microscopy. Cell cycle distribution and possible activation of caspase-dependent pathway of cell death w... see more
Hong-Mei Zhuang, Xiao Hu, Shu-Rong Hong, Ping-Ping Zhou, Yu Zhang, Ling Li
The present study was aimed to investigate the effect of 18?-glycyrrhetinic acid on induction of apoptosis and DNA-damage in HR5-CL11 cervical carcinoma cells. The results revealed 73.6% reduction in HR5-CL11 cell viability on treatment with 5 µM concentr... see more