SUMMARY
Cancer accounts as one of the leading causes of morbidity and mortality. Recent studies focus on the efficiency of phytochemicals in cancer therapy. Influence of quercetin, a flavonoid on the effect of ?d T cells and Wnt/ß-catenin signalling pathway in human colon cancer cells (HT55 and HCT116) was investigated. Quercetin at 15-120 µM was observed to markedly reduce the viability of HT55 and HCT116 cells. Quercetin exposure significantly increased ?d T cell proliferation and also raised the expressions of granzyme B (Gra B), perforin (PFP), and interferon- ? (IFN-?) in ?d T cells. Reduced ß-catenin expression with increased expressions of phosphorylated- ß-catenin, axin1 and 2 were observed in HT55 and HCT116 cells on exposure to quercetin. However ß-actin expression was found to be not much altered. The results suggest that quercetin was able to efficiently potentiate the effect of ?d T cells and modulate Wnt/ß-catenin signalling pathway.