22 articles in this issue
Kandasamy Sasikumar, Asit Ranjan Ghosh
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Shivraj Hariram Nile, Young Soo Keum
Talambedu Usha, Sushil Kumar Middha, Derhasat Narzary, Birendra Kumar Brahma, Arvind Kumar Goyal
Xiang-Yang Yao, Qin Bai
Taraxerol is known to exhibit anti-inflammatory and anti-cancer activity. However, cytoprotective effect of taraxerol on hepatocytes has not been reported. In the present study, we investigated the hepatoprotective effect of taraxerol in the human hepatic... see more
Zaman Hayat, Mueen Ahmad Chaudhry, . Alamgeer
The aim of this study was to validate the traditional uses of ulcerene, a poly-herbal formulation in ethanol, aspirin and stress-induced gastric ulcer model of rat. The extent of gastric ulcer formation was studied, using ulcer score, ulcer index, percent... see more
Jagannathan Padmavathy, Saravanan Devarajan
The natural products are the chemical constituents that are generated from the living organism. The natural products are isolated from the plants, animals, and microorganisms which are used in drug design and drug discovery. Natural product is then m... see more
Ashutosh Bahuguna, Imran Khan, Vivek K. Bajpai, Sun Chul Kang
Quantification of cell viability and proliferation form the fundamental for numerous in vitro assays in response to external factors. An MTT assay is a colorimetric assay based on assessing the cell metabolic activity. A549 Lung adenocarcinoma cell line w... see more
Alshammari Fanar Hamad, Jong-Hun Han, Irfan Ahmad Rather
Atopic dermatitis is a skin disease characterized by allergic skin inflammation, redness and itching. The animal model is necessary to find out new drugs. The DNCB-induced animal model of atopic dermatitis includes the following steps: 1) Selection of ani... see more
Quazi Sahely Sarah, Fatema Chowdhury Anny, Mir Misbahuddin
Brine shrimp lethality assay is an important tool for the preliminary cytotoxicity assay of plant extract and others based on the ability to kill a laboratory cultured larvae (nauplii). The nauplii were exposed to different concentrations of plant extract... see more
Hamid Kariman, Firoozeh Vajihi, Afshin Amini, Ali Shahrami, Ali Arhami-Dolatabadi, Majid Shojaee, Alireza Baratloo
The present study was a double-blind clinical trial to compare the efficiency of hysocine and diazepam in vertigo treatment. Eligible patients (n=69) were randomly divided into 2 groups of 5 mg hyoscine and 10 mg diazepam. Severity of vertigo was measured... see more
Ali Abdolrazaghnejad, Mohsen Banaie
The aim of the present study was to investigate two pharmaceutical groups including fentanyl-midazolam and midazolam-ketamine used as patient seda-tion analgesia for the orthopedic emergency procedures. This is a prospective randomized double-blind and pl... see more
Di-Wen Shou, Yue-Lin Zheng
The primary objective of the current work was to investigate the antitumor potential of Primula macrophylla extracts in human colon cancer cell line (Colo-205) along with evaluating the effects on apoptosis induction, cell cycle arrest and mitochondrial m... see more
Ibtissem Boulacel, Lakhdar Djarri, Salima Azzouzi, Kamel Medjroubi, Ibrahim Demirtas, Hocine Laouer, Salah Akkal
In this study, we focused on the isolation and identification of the main compounds, triterpene, sterol, phenolic and fatty acid from the aerial parts of Physospermum verticillatum, which has not been previously reported. Dichloromethane, ethyl acetate an... see more
Ambreen Aleem, Khalid Hussain Janbaz
This study was conducted to rationalize the traditional uses of Cenchrus ciliaris in gastrointestinal disorders using in vivo and ex vivo assays. The antidiarrheal effect was evaluated in rats by the castor oil-induced diarrheal model. C. ciliaris (100, 3... see more
Ni Kou, Hyejoung Cho, Hye-Eun Kim, Qiaochu Sun, Kyuhyeon Ahn, Hyeongjoon Ji, Hongran Choi, Okjoon Kim
The apoptosis resistance restricts the efficacy of traditional therapies of head and neck squamous cell carcinoma (HNSCC). To overcome this problem, Atractylodes macrocephala, a traditional Korean and Chinese herbal medicine, has been used in clinical pra... see more
Dhineshkumar Manoharan, Kannan Kulanthai, Gnanavel Sadhasivam, Vijayan Raji, Paalvannan Thayumanavan
Series of indoline derivatives were synthesized using N-(4-aminophenyl)indoline-1-carbothiamide as a precursor. The confirmation of synthesized compounds was done by 1H-NMR, 13C-NMR, LC-MS (ESI) and FT-IR. In vitro antidiabetic activity of synthesized ind... see more
Sinjumol Thomas, Bince Mani
Essential oils are known for their medicinal value since time immemorial and continue to be of vital importance until the present day. The present study describes the composition, antibacterial and anti-oxidant potential of rhizome oil of Hedychium matthe... see more
Anam Saeed, Fazli Wahid, Hafiz Majid Rasheed, Rahila Qayyum, Abdul Jabbar Shah, Taous Khan
The current study was aimed to investigate the extracts from Heliotropium strigosum and Trapa bicornis phytochemically for various constituents and pharmacologically for gastro-intestinal disorders. Phytochemical analysis indicated the presence of alkaloi... see more
Vinay Bharadwaj Tatipamula, Kishore Naidu Killari, Alekhya Ketha, Vedula Girija Sastry
In this work, Taxithelium nepalense ethanolic extract and its fractions were evaluated for the antidiabetic activity in rat based on phytochemical and free radical scavenging properties. The ethanolic extract, fraction IV and V significantly attenuated th... see more
Gökalp Iscan, Fatih Göger, Betül Demirci, Yavuz Bülent Köse
In the present study, aerial parts of Nepeta cilicica were hydro-distilled for the essential oil. Furthermore, air-dried plant materials were extracted with methanol. According to GC-MS results, 35 compounds were characterized in the oil (totally 92%). Ca... see more
Aamer Saeed, Danish Shahzad, Fayaz Ali Larik, Pervaiz Ali Channar, Haroon Mahfooz, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo, Ghulam Shabir
A series of 4-aryl-2,6-dimethyl-3,5-bis-N-(aryl)-carbamoyl-1,4-dihydropyri-dines 6a-6h were prepared by using the one-pot three component synthetic method. The target compounds 6a-6h were synthesized by reacting two molar equivalents of ketone functionali... see more
Lalit Kishore, Navpreet Kaur, Anu Kajal, Randhir Singh
The present study was aimed to evaluate petroleum ether and hydroalcohol extracts of Eruca sativa seeds in the treatment of diabetic nephropathy in the rat model. GC-MS analysis of petroleum ether extract revealed the presence of fatty acids and erucic ac... see more