40 articles in this issue
Hu Li, Yan Xu, Li Yang, Lei He
In human cervical cancer cells pro-apoptotic effect of tanshinone IIA isolated from the ethanol extract of Scutellaria barbata was investigated. Tanshinone IIA treatment resulted in apoptosis and mitochondrial membrane potential loss in the cervical cance... see more
Zhenhua Du, Xiaolin Ma
We investigated dose-dense weekly paclitaxel and carboplatin compared with conventional paclitaxel and carboplatin treatment on stage II-IV ovarian cancer patients. Between July, 2011, and October, 2014, a total of 221 patients was randomly assigned to re... see more
Muhammad Naveed Mushtaq, Muhammad Shoaib Akhtar, Alamgeer .
The present study was carried out to evaluate the seeds of Pennisetum glaucum for its blood pressure lowering effect in rats. Aqueous-methanolic extract of P. glaucum seeds in 250, 500 and 1000 mg/kg doses was studied in normotensive, egg-feed diet and gl... see more
Da Chen, Xiao-Yi Zhang, Fa-Zhu Zheng, Hai-Tao Wang, Jian-Liang Cai, Ming Xia
Escopoletin, a phenolic compound belonging to anthocyanin family shows promising antioxidant activities. In the present study, anti-cancer effects of escopoletin treatment in DU145 cells were investigated. The sulphorhodamine-B staining and annexin V and ... see more
Malgorzata Elzbieta Knapik-Czajka
Multienzyme 2-oxoglutarate complex (2-OGDH) together with branched chain ?-ketoacid dehydrogenase (BCKDH) and pyruvate dehydrogenase belong to the family of mitochondrial 2-oxoacid dehydrogenases. Hypolipidemic drugs, bezafibrate and fenofibrate, up... see more
Habiba Akhter Bhuiyan, Kipchu Tshering, Mir Misbahuddin
Spectrophotometric method of arsenic estimation in nails has four steps: a) washing of nails, b) digestion of nails, c) arsenic generation, and finally d) reading absorbance using spectrophotometer. Although the method is a cheapest one, widely used and e... see more
Jun Tang, Juan-Juan Zhao, Zhi-Hong Li
The aim of the study was to see the antiproliferative and apoptotic effects of ethanolic herbal extract of Artemisia sieversiana against three human colon cancer (HT-29, HCT-15 and COLO-205) cells. The cytotoxicity of the extract on these cell lines was e... see more
Jing Yao Wang, Nan Zhang, Xiaojie Yang, Danli Gao, Lirong Yin, Shuying Ji
The purpose of this study is to assess whether MHC class I-presented tumor antigen is appraisable for T-cell responses against ovarian cancer. In ovarian cancer cell, human leukocyte antigen A2 (HLA-A2) associated with peptides was used to promote th... see more
Huawei Zhang, Chuanfeng Ruan, Xuelian Bai
Ten fungal strains isolated from Edgeworthia chrysantha, one of traditional medicinal plants in China, were evaluated their antimicrobial activities against three human pathogens, Escherichia coli, Staphyloccocus aureus and Candida albicans, and two phyto... see more
Bo Yu, Yu Jiang, Yue Liu, Tonghui Ma, Hong Yang
Inhibition of cystic fibrosis transmembrane conductance regulator (CFTR) and Ca2+-activated Cl- channel (CaCC) represents an attractive approach for the treatment of secretory diarrhea. The aim of the study is to investigate the molecular basis of the ant... see more
Muhammad Saad Ur Rehman, Sairah Hafeez Kamran, Mobasher Ahmad, Usman Akhtar
The purpose of this study was to investigate the anti-diabetic effect of crude Pistacia lentiscus gum (mastic gum) in alloxan-treated diabetic rat model. The crude P. lentiscus (100 mg/kg) showed significant (p<0.001) reduction in blood glucose as comp... see more
Musaddique Hussain, Shahid Masood Raza, Khalid Hussain Janbaz
In vitro and in vivo studies were undertaken to evaluate the pharmacologically mechanistic background to validate the traditional uses of Rumex acetosa in the treatment of emesis and gastrointestinal motility disorders such as constipation and diarrhea. I... see more
Asif Husain, Munendra M. Varshney, Versha Parcha, Aftab Ahmad, Shah Alam Khan
A new series of N-({5-(substituted aryl)-furan-2-yl}-methylidene)-hydrazides were synthesized with a new class of Schiff bases derived from the reaction of substituted phenyl-1-ketohydrazide 2 or 2-(4-chloro-3-methylaryloxy) acetohydrazide 3 with differen... see more
Fatema Nasrin, Md. Lukman Hakim
In this study the antidiarrheal activity of ethanolic extracts of the leaves of Mikania cordata and Litsea monopetala was evaluated. Diarrhea was induced in mice by oral administration of castor oil (0.5 mL) 30 min after the administration of the extracts... see more
Arif Khan, Rahmat Ali Khan, Mushtaq Ahmed, Nadia Mushtaq
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Xiao-Bing Li, Yun-Gang Deng, Jia-Ping Hu, Zhi Wang, Rong-Zhen Xie, Hong Luo, Xiao-Yun Hu
Resveratrol is a stilbenoid compound, and a promising potent chemopreventive bioactive agent. Here, we showed for the first time that the combined treatment with resveratrol and TRAIL drastically induced apoptosis in human colon cancer cells when compared... see more
Shafiq ur Rahman, Muhammad Ismail, Muhammad Raza Shah, Marcello Iriti, Muhammad Shahid
The current study aims to investigate the phytochemical constituents, antioxidant, ß-glucuronidase inhibitory and anticancer activities of Trillium govanianum rhizome. Phytochemical screening revealed the presence of steroidal glycosides, saponins, sterol... see more
Hammad Saleem, Irshad Ahmad, M. Shoaib Ali Gill
The aim of this study was to evaluate diuretic activity of aqueous methanolic extract of Euphorbia granulate in rats. Albino rats were divided into five groups. Group I served as reference, Group II as standard and Group III, IV and V served as test. The ... see more
Wafa Majeed, Tanweer Khaliq, Bilal Aslam, Junaid Ali Khan, Asra Iftikhar
Peptic ulcer disease (PUD) is a main source of morbidity and mortality worldwide. It is characterized by erosions in mucosal linings of stomach and duodenum. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori are mainly responsible for... see more
Qian Xu, Kai Cao, Yan-Hong Xiao, Chao Du, Xian-Hui Dong, Yu Wang, Xiao-Hui Zhou
The aim of this study was to investigate the effects of paeonol on the expression of NF-?B pathway induced by homocysteine. After Human umbilical vein endothelial cells exposed to homocysteine for 24 hours, paeonol (0.15-0.6 mmol/L) improved the cel... see more
Jun-Fei Zhang, Bo Liu, Cong-Xin Chen
The construction of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives (4a4m), by the condensation isatoic anhydride, appropriate amines and 2-formylbenzoic acid by using silica sulfuric acid as catalyst was reported. These dihydroisoindolo[2... see more
Ana Sabo, Ana Tomas, Natasa Tomic, Momir Mikov, Olga Horvat, Radmila Popovic, Zdenko Tomic
Ciprofloxacin is often used in treatment of complicated urinary tract infections in areas with high rates of resistance to first line agents. The aim of this study was to evaluate efficacy of ciprofloxacin in standard dosing regimens in treatment of compl... see more
Muhammad Zeeshan Ali, Khalid Hussain Janbaz, Malik Hassan Mehmood, Anwar Hassan Gilani
Polygonum bistorta is a popular medicinal herb used to treat diarrhea. This study provides pharmacological basis to its folk use in diarrhea using in vivo and in vitro assays. Administration of P. bistorta rhizomes extract to mice offered protection... see more
Narendranath Alluri, Mala Majumdar
Rahmat Ali Khan, Muhammad Rashid Khan, Arif Khan
Fatih Göger, Yavuz Bülent Köse, Gamze Göger, Fatih Demirci
The aim of this study was to reveal the phytochemical constituents, antioxidant and antimicrobial activity of Ajuga orientalis. According to the antimicrobial results, the methanol extract of A. orientalis showed a MIC value of 312.5 µg/mL against the tes... see more
Rafi Ullah, Jehan Bakht, Mohammad Shafi
The present study investigates antimicrobial and anti-oxidant potential of different solvent extracted samples from Periploca hydaspidis through disc diffusion assay. The data revealed that all the extracts reduced the growth of the tested microbes using ... see more
Amartya Banerjee, S. M. Firdous
Abdullah Aslan, Didem Boydak, Muhammed Ismail Can, Tuncay Kuloglu
The objective of this study was to examine whether Nigella sativa plays a protective role against the damage in the lung by administering carbon tetra-chloride (CCl4) to rats. Male Wistar albino (n=28, 8 weeks old) rats were divided into 4 groups: a) nega... see more
Tie-Ling Li, Hai-Feng Guo, Fu-Juan Li, Zhi-Guo Sun, Heng-Chun Zhang
A convenient synthesis of 6H-1-benzopyrano[4,3-b]quinolin-6-one derivatives was reported using 4-chloro-2-oxo-2H-chromene-3-carbaldehyde with different aromatic amines using silica sulfuric acid. The compounds were tested for their anticancer activity aga... see more
Rahul Chandran, Saikumar Sathyanarayanan, Murugan Rajan, Muniyandi Kasipandi, Thangaraj Parimelazhagan
The article discusses anti-oxidant oral glucose tolerance and anti-hyperglycemic potentials of Syzygium calophyllifolium. Extracts from successive solvent extraction were tested for the total phenolic, tannin, flavonoid content and free radical scave... see more
Bing-Guo Luan, Cai-Xia Sun
In the present study 32 women with polycystic ovary syndrome were treated with glabridin (10 µM) daily for 12 months. The results revealed a significant reduction in serum testosterone from 95.3 ± 23.6 to 49.8 ± 12.7 ng/dL and fasting insulin concentratio... see more
Rajib Majumder, Irfan A. Rather, Vivek K. Bajpai, Yong-Ha Park
Serum pathogen-free (SPF) embryonated egg for culturing virus has three main steps: a) candling of egg, b) inoculation of egg and c) harvesting of inoculated egg. Furthermore, hemagglutination assay consists of only one step. The method is easy to perform... see more
Md. Abu Sufian, Mohammad Rashedul Haque
The crude methanol extract of Hygrophila schulli and its petroleum ether, chloroform, ethyl acetate and aqueous soluble Kupchan partitionates were investigated for in vitro cytotoxic, thrombolytic, membrane stabilizing and anti-oxidant activities. In the ... see more
Anggana Roy, Yasir Bashir, Irfan Ahmad Rather, Bolin Kumar Konwar
There is abundant genetic diversity of pharmacologically important plants around the globe and this pool of genetic variation serves as the base for selection as well as for plant improvement. The major cause of such genetic diversity is the variation in ... see more
Pattan Sirajuddin Nayab, Madhusudana Pulaganti, Suresh Kumar Chitta, Mohammad Oves, Rahisuddin .
A new series of N-substituted phthalimide derivatives were prepared by condensation of appropriate amount of n-amino tetrachlorophthalimide with respective aldehyde in glacial acetic acid. The structural investigation of the synthesized compounds was done... see more
Yong-Ji Li, Ting Zhang, Jian-Xin Tu, Gang Li, Yan Zhou
The study aimed to determine the effect of tangeretin in inhibiting the interleukin-1ß (IL-1ß)-induced proliferation of RASFs and suppression of the production of inflammatory mediators. RASFs were isolated from synovial tissue obtained from patients with... see more
Shekar Ponnuswamy, Sathishkumar Kannaiyan, Gopikrishnan Venugopal, Radhakrishnan Manikkam
Cristina Nastas?, Mihaela Duma, Brindusa Tiperciuc, Ovidiu Oniga
Li-Wei Liu, Li-Xin Zhu, Bo Liu
We detected the expression of microRNA-132 in Chinese patient with liver cancer and evaluated down-regulation of microRNA-132 affect on cell growth and apoptotic of liver cancer cell. Twenty four patients with liver cancer and 24 normal patients were obta... see more