39 articles in this issue
Rizwan Ahmad, Mohd. Mujeeb, Aftab Ahmad, Firoz Anwar
Withdrawn by the Editor
Shumaila Andleeb, Muhammad Masood Ahmed, Musaddique Hussain
Papar has been withdrawn by the editor
Vivek K. Bajpai, Irfan A. Rather, Rajib Majumder, Shruti Shukla, Abhinav Aeron, Kangmin Kim, Sun Chul Kang, R. C. Dubey, D. K. Maheshwari, Jeongheui Lim, Yong-Ha Park
Lactic acid bacteria exhibit the most effective potential to divert significant amount of fermentable sugars towards the biosynthesis of functional exopolysaccharide. Exopolysaccharides from lactic acid bacteria are receiving a renewed interest due to the... see more
Shruti Shukla
Proteins for foods, in addition to providing nutrition, should also possess specific functional properties that facilitate processing and serve as the basis of product performance. Soy protein is a major component of the diet of food and is increasingly i... see more
Muhammad Aslam
The Forced Swim Test (FST) is a rodent behavioral paradigm utilized for assessment of potential antidepressant-like medications. In this model the mice are put in a plexiglas tank. The tank is loaded with water and the behavior of the mice to escape the t... see more
Vivek K. Bajpai, Irfan A. Rather, Gyeong-Jun Nam
Although several naturally available drugs have been historically used for the treatment of diabetes mellitus throughout the world, few of them have been validated by scientific criteria. Before approval of any drug developed it should pass through animal... see more
Elnaz Jafarvand, Mahdieh Abbasalizad Farhangi, Beytollah Alipour, Manouchehr Khoshbaten
This randomized double-blind placebo-controlled trial was conducted on 41 patients with non-alcoholic fatty liver disease. Patients in intervention group received 100 mg/day coenzyme Q10 (CoQ10) for four weeks. There was a significant reduction in waist c... see more
Shu-Hong Hu, Hui Yu, Xue-Qin Gong, Ying-Hong Zhang
The aim of the current investigation was to design, synthesize and demonstrate the anticancer and apoptotic activity of trifluoromethyl-phenyl-triazolyl derivative of beta-bisabolol (TTB) in ME-180 human cervical cancer cells. MTT and clonogenic ass... see more
Yogendra Narayanrao Keche, Radha Yegnanarayan, Shreepad Bhat
This study was conducted to observe the effect of vitamin B12 supplementation on glycemic control in poorly controlled hyperhomocysteinemic type 2 diabetic patients by measuring HbA1c levels at baseline and 4 weeks. Patient having serum homocysteine more ... see more
Mouna Kchaou, Hichem Ben Salah, Rania Mhiri, Noureddine Allouche
The present study was carried out to explore the anti-acetylcholinesterase activity and anti-oxidant effect as well as content of phenolic compounds of various extracts from Zygophyllum album. It was observed that dichloromethane and ethanol extracts were... see more
Shang-Jin Peng, Jue-Wei Chen
The present study investigates the effect of rubriflordilactone A on the viability and its underlying mechanism in gastric cancer cell lines (SNU-1 and SNU-5) and normal gastric epithelial cell line (GES?1). Incubation of the gastric cancer and non cancer... see more
B. Vishwanathan, B. M. Gurupadayya, K. Venkata Sairam
In the present study, a series of 1,3,4-oxadiazole derivatives (4a-4k) derived from benzimidazole were docked onto factor Xa (PDB: 1NFY) protein using SYBYLX 2.1. and also evaluated for in vitro clot lysis for thrombolytic activity. The synthesized molecu... see more
Xue-Mei Gong, Cheng-Jiu Hu, Quan-Jing Zhao, Dong-Mei Shi
Polyphenolic compounds present in fruits, vegetables and grains are bioactive molecules which elicit a wide range of responses both in vivo and in vitro. The aim of this study was to investigate whether the soybean isoflavone equol could induce apoptosis ... see more
Seyed Abbas Mirmalek, Tina Parsa, Yekta Parsa, Soheila Yadollah-Damavandi, Seyed Alireza Salimi-Tabatabaee, Ehsan Jangholi, Sahar Hosseini, Soheil Ashkani-Esfahani, Hanieh Abooghadareh, Erfan Haghighifard
Iris florentina is an ancient herbal remedy which was prescribed by many physicians due to its positive effects on dermatological problems, specifically skin wounds. Hence, we aimed to investigate the effects of this agent on full-thickness excisional ski... see more
Bilal Muhammad Khan, Jehan Bakht
The antifungal, anti-yeast and anti-oxidant effects of Calamus aromaticus leaves were studied. The extract showed mild activity against two fungal strains and strong activity against the yeast. The results also indicated the presence of extremely high DPP... see more
Da-Lu Li, Zhu-Liang Wei, Wen-Mei Zhang, Zhi-Gang Li
Cabozantinib is a tyrosine kinase inhibitor involved in inhibition of cell proliferation and colony formation. We studied anti-cancer properties of cabozantinib in oral squamous cell carcinoma cells. The viability of BHY and HSC-3 cells decreased with inc... see more
M. Punnam Chander, C. R. Pillai, P. Vijayachari
The aim of this study was to assess the antimalarial activity of nine medicinal plants used by Karens of Andaman and Nicobar Islands, against Plasmodium falciparum chloroquine-sensitive MRC-2 isolate. The methanol extracts were obtained by cold percolatio... see more
Nai-Xiong Peng, Chun-Xiao Liu, Xi-Sheng Wang, Ze-Jian Zhang, Su-Cai Liao
Prostate cancer is the major cause of cancer-related deaths worldwide in men. There are new treatment methods and drugs are being developed with promising results in two of the prostate cancer cell lines (PPC-1 and TSU-Pr1). These two cells were treated w... see more
Radhakrishnan Manikkam, Shekar Ponnuswamy, Jerrine Joseph, Vanaja Kumar
Extracellular pigment from the forest soil Streptomyces sp SFA5 was produced by submerged fermentation using yeast extract malt extract broth. Crude pigment from the medium was extracted using ethyl acetate. Antitubercular activity of the pigment was test... see more
Xiao-Jun Zhong, Hui Jia, Ji-Long Hu, Fei Le, Xiao-Ming Zhong
The objective of the current study was to evaluate the antiproliferative and apoptotic activities of acetoxyroyleanone against various cancer cells along with studying its effect on chromatin condensation, NF-?B and caspase-3 expressions and cell migratio... see more
Elizabeth George, Muniyandi Kasipandi, Mudili Vekataramana, Kalagatur Naveen Kumar, Joseph Anthuvan Allen, Thangaraj Parimelazhagan, Natarajan Gopalan
In the present study, the anti-oxidant and cytotoxic effects of the different solvent extracts of Pogostemon mollis were analyzed. The phenolic, tannin and flavonoid contents were highest in the ethyl acetate extract and analogous to the antioxidant activ... see more
Venkatramanan Varadharajan, Sethupathi Shanmugam, Arulvel Ramaswamy
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Imran Ahmad Khan, Khalid Hussain Janbaz, Fatima Saqib
This study evaluates the antidiarrheal activity of Rumex vesicarius (leaf) by using in vitro and in vivo assays. Antidiarrheal effect of R. vesicarius was evaluated using castor oil-induced diarrhea model in rat. Weight and volume of the intes... see more
Sairah Hafeez Kamran, Mobasher Ahmad, Durre Shahwar, Muhammad Ajaib
Leaves of Loranthus pulverulentus have been used ethnically in Pakistan for controlling blood glucose levels. The present study was designed to investigate the anti-diabetic and anti-oxidant potential of the methanolic extracted fractions of L. pulverulen... see more
Venugopal Gopikrishnan, Manikkam Radhakrishnan, Raasaiyah Pazhanimurugan, Thangavel Shanmugasundaram, Ramasamy Balagurunathan
Thirunavukkarasu Rajasekar, Sivaraj Anbarasu, Manikkam Radhakrishnan, Joseph Jerrine, Kumar Vanaja
Hong Li, Xu Chao, Chun-Ling He, Xin-Mei Wang, Man Liang, Chang-Hu Dong
The aim of the present study was to synthesize epoxide derivative of alloimperatorin and evaluating its antitumor and apoptotic effects in acute myeloid leukemia HL-60 cells. The cytotoxic effects were demonstrated by MTT assay. Fluorescence microscopy al... see more
Muhammad Kifayatullah, Pinaki Sengupta
The purpose of this study was to evaluate the effects of Pericampylus glaucus extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. The ethanolic extract were administered orally at three different d... see more
Yong-Bin Song, Shao-Hui Zhou, Hong-Shang Cui, Hui-Ning Liu, Li-Jun Liu
The present study demonstrates the effect of casticin on esophageal squamous cell carcinoma cell lines, TE-1 and TE-15. The cells were treated with various concentrations (10-50 ?M) of casticin for different time periods. The results revealed that castici... see more
Saudy Saret Pablo-Pérez, María Mirian Estévez-Carmona, María Estela Meléndez-Camargo
The aim of this study was to evaluate the diuretic activity of Eysenhardtia polystachya bark aqueous extract at different doses in a rat model. Different doses of E. polystachya (125, 250, 500 and 750 mg/kg body weight), furosemide (4 mg/kg) and vehicle w... see more
Yi Zheng, Yu Wang, Yuan-Hong Shang
The objective of the present investigation was to study the antibacterial effect of seneciolactone isolated from the methanolic extract of Senecio scandens against five bacterial pathogens which are known to cause several gastrointestinal tract diseases. ... see more
Damayanthi Dalu, Satyavati Dhulipala
This study was conducted to provide the evidence for the mechanism of anti-diabetic activity of Cocculus orbiculatus, Leea indica and Ventilago maderaspatana. This was accomplished by employing methods like uptake of glucose, glycogen synthesis... see more
Ravi Mundugaru, Padmaja Udaykumar, Sivanesan Senthilkumar, Sudhakara Bhat
The present study reveals the protective effect of Garcinia pedunculata aqueous fruit extract in isoprenaline-induced myocardial infarction in Wistar rats. Isoprenaline (200 mg/kg) administration subcutaneous once daily for two consecutive days significan... see more
Yu Jiang, Rong-Rong Zhang, Li-Juan Yang, Zhen Wu, Huai-Ping Chen, Sai Zhao, Zhao-Fang Tian
This study aimed to investigate the efficacy of shenfu injection for the protection of neonates with asphyxia. Eighty neonates with asphyxia were randomly divided into two groups, treatment group and control group (n=40). Both groups received intervention... see more
Abdur Rahim, Muhammad Medrar Hussain, Ihsan Ullah Khan Altaf
In the present study various solvent extracts from the leaves of Fernandoa adenophylla were screened for their phytochemical and antimicrobial potentials. Preliminary phytochemical screening of leaves extracts showed the presence of alkaloids, glyco... see more
Irfan Ullah, Jamshaid Ali Khan, Achyut Adhikari, Muhammad Shahid
The present study investigates the hepatoprotective potential of Monotheca buxifolia fruit hydro-ethanolic extract, against isoniazid- and rifampicin- induced hepatotoxicity in rats. Phytochemical investigations lead to the isolation of oleanolic acid and... see more
Shruti Shukla, Rajib Majumder, Laxmi Ahirwal, Archana Mehta
The antibacterial mechanism of action of Caesalpinia bonducella seed oil on membrane permeability of Listeria monocytogenes NCIM 24563 (MIC: 2 mg/mL) and Escherichia coli ATCC 25922 (MIC: 4 mg/mL) was determined by measuring the extracellular ATP concentr... see more
Youchao Jia, Aimin Zang, Yanguang Feng, Xiao-Fang Li, Ke Zhang, Hefei Li, Ruiyao Wang, Yaning Wei, Ran Huo
It was aimed to explore the expression level of miRNA-486 and miRNA-499 in the plasma of lung cancer patients and analysis their differences in expre-ssion. The expression level of both miRNA-486 and miRNA-499 in the plasma of non-small cell lung cancer (... see more
Vivek K. Bajpai, Siddhartha Singh, Archana Mehta
Current research analyzes the chemical composition of Ligustrum lucidum flower essential oil obtained by the hydrodistillation, and examines its anti-microbial mode of action against food-borne pathogenic bacteria. Gas chromatography-mass spectrometry ana... see more