38 articles in this issue
Dharmaraj Senthilkumar, Krishnan Anbarasu, Sivaraman Jayanthi
Human ?-aminobutyric acid aminotransferase (GABA-AT), a pyridoxal phosphate dependent enzyme is responsible for the degradation of the inhibitory neurotransmitter GABA. Currently, GABA-AT is a potential drug target for epilepsy due to the selective inhibi... see more
Satyajit Dutta, G. Raghava Ravali, Supratim Ray, K. Nagarajan
In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic acti... see more
Mohammad Saleem, Iram Irshad, Muhammad Kashif Baig, Faiza Naseer
The chloroform and methanol extracts of Opuntia monacantha were studied for its hepatoprotective effect against paracetamol induced liver damage in rabbits. Results proved that both extracts at 200, 400 and 600 mg/kg body weight in one week protocol showe... see more
Attiqa Naz, Muhammad Saeed, Muhammad Medrar Hussain, Muhammad Saqib Ishaq
Extracts from the whole plant of Thymus linearis were extracted with methanol (crude), chloroform, n-hexane, ethyl acetate and butanol and screened for their phytochemical and antimicrobial potentials. Preliminary phytochemical screening of plant extracts... see more
Md. Azizur Rahman, Arshad Hussain
MTT assay and DAPI staining test were performed to evaluate anticancer potential and to assess apoptosis inducing effect of methanolic extract of Cordia dichotoma leaves (MECD) against human cervical cancer cell line (HeLa). Changes in MMP and intracellul... see more
Jian Yang, Ji-Xia Li, Zhe Song, Xi-Yan Xia
Allergic transfusion reaction is an anomaly that develops within several hours of transfusion which is usually treated by antihistamine. In the present study, we are looking into daucosterol, an extract of Traditional Chinese Medicine (TCM) Cordyceps, as ... see more
Zhi-Gang Wang, Jin-Peng Wang, Fang Wang, Yi-Hua Wang, Pei-Cheng Cao
In the present study, effect of retinoic acid ortho-hydroxy aniline amide (RAA), an analog of retinoic acid (RA) was investigated on neurotrophin mediated cell growth and proliferation in hippocampus-derived stem cell clones. The results revealed that ret... see more
Yang Fang, Hong Zhou, Jian-Fu Xia, Jie-Jun Lin, Ri-Zeng Li, Da-Qing Yang, Mai-Yu Xu, Xiao-Yang Li
Colorectal cancer is one of the leading causes of death worldwide. Wnt/beta-catenin signalling pathway plays a central role in normal cellular responses, making it a potent target in cancer therapy. Study was taken to assess whether ellagic acid modulates... see more
Prashanthi Kuruvalli, Varalakshmi Kilingar Nadumane
Three Actinomyctes with potential bioactivity are successfully isolated from the marine water samples and identified as Prauserella marina, Streptomyces sindenensis and S. spiroverticillatus. The ethyl acetate extracts from the three Actinomycetes are fou... see more
Si-Ping Wang, Li Yu, Jie Xie, Xiao-Ming Liu, Hong Li
The present study demonstrates the effect of vitexicarpin on down-regulation of GNAO1 in human gastric cancer cell lines. The results from Western blot analysis revealed that vitexicarpin treatment inhibited the GNAO1 expression in MKN-45 cells at a conce... see more
Md. Ali Asgar, Gulsiri Senawong, Banchob Sripa, Thanaset Senawong
Chemotherapy with cisplatin in cholangiocarcinoma produces adverse effects and leads to resistance development by tumors. We aimed to evaluate anti-cancer effects by co-administration of cisplatin and scopoletin in cholangiocarcinoma cells. MTT assay, med... see more
Jin-Kai Xu, Qing-Gong Yuan, Peng Luo, Xiao-Li Sun, Jian-Cang Ma
Breast cancer is one of the most prevalent cancers among women worldwide. Chemotherapy generally leads to drug resistance and severe side effects thus making it crucial to identify and develop highly efficient chemotherapeutic agents. Recently, edible mus... see more
Mohammad Shoaib, Ismail Shah, Niaz Ali, Syed Wadood Ali Shah
In this study we screened the essential oil of Artemisia macrocephala for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory potentials. Ellman's assay method was used to investigate the enzyme inhibitory potential of the essential oi... see more
Zhen Chen, Ling-Yun Gu, Jun Zhou, Qin Wang, Hui Gao, Zhong-He Yu
Lung cancer is the most frequently occurring lethal cancers in men and women population. The aim of the present study is to observe the overexpression pattern of phosphorylated MARCKS in the nicotine-derived nitrosamine ketone (NNK) induced lung cancer mi... see more
Muhammad Khurram Afzal, Muhammad Uzair, Bashir Ahmad Chaudhry
Ruellia species are traditionally used for the treatment of flu, fever and inflammation. The aim of this study was to evaluate the anticancer activity of Ruellia squarrosa extracts against human prostate cancer (PC3) cell line. Dichloromethane and methano... see more
Ju-Hong Tu, Wei-Hua Lou, Rong Huang, Ai-Min Zhao
The study demonstrates the effect of vernolepin on proliferation and apoptosis in ovarian cancer cell lines. The inhibition of cell growth was significant at 30 ?M concentration after 48 hours in both OVCAR-3 and SK-OV3 cell lines. Phase-contrast microsco... see more
Yun-Lei Dai, Gui-Lian Shao, Fang Wang
Asthma is one of the most common chronic inflammatory diseases characterized by airway infiltration of inflammatory cells inducing hyper-responsiveness. Due to the inefficacy of currently used drugs to definitely cure asthma, there is an insistent need fo... see more
Aftab- Ullah, Mahmood Ahmad, Taseer Ahmad, Faiza Naseer Naseer
DOI: http://dx.doi.org/10.3329/bjp.v10i1.20620
Rawshan Ara Perveen, Md. Sayedur Rahman
Cancer patients having moderate to severe pain need immediate pain relief. Immediate release formulation of morphine is not available in Bangladesh. This open label randomised two phase crossover clinical trial was conducted to compare strength, efficacy,... see more
Kosanam Neeraja, Rabindra Debnath, S. M. Firdous
The present work deals with the study of the ethanolic extract of fruits of Sechium edule for cardioprotective activity. Cardioprotective activity of the ethanolic extract of fruits of Sechium edule was determined by the administration of isoproterenol (6... see more
Wenbin Li, Hongyan Sun, Jianwu Zhou, Yabiao Zhang, Linjie Liu, Ye Gao
The present study was carried out to identify antibacterial and antioxidant characteristics of traditional aqueous extracts derived from three traditional Chinese medicinal plants (Scutellaria baicalensis, Coptis chinensis and Sonchus oleraceus). It was i... see more
Hong Liu, Chaohua Wang, Hua Yang, Fengjie Wang
Common chemotherapeutic agents such as oxaliplatin often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is difficult to treat and responds poorly to common analgesics, which represents a challenging clinical issue. Fiset... see more
Leile Rahimi Ahar, Moayad Hossaini Sadr, Karim Zare, Samad Motameni Tabatabaei
In this investigation, unsubstituted pyrazolin-3(5)-ones (MePzO= 3-methyl-5-pyrazolone, PrPzO= 3-propyl-5-pyrazolone and PhPzO= 3-phenyl-5-pyrazolone) have been synthesized. The synthesized compounds were also screened for their antibacterial activity aga... see more
Nazmun Nahar Alam, Ferdous Ara, Md. Jalal Uddin Iqbal
The objectives were to evaluate the prevalence, pattern and rational of psychotropic drugs prescribing by general physicians in two teaching hospitals in Bangladesh in non-psychiatric patient. 320 patients from Sir Salimullah Medical College Hospital... see more
Hasan Mahmud Reza, Md. Abu Taher Sagor, Md. Ashraful Alam
The present study investigates the pathological implications of parenchymal iron overload due to CCl4 treatment in liver dysfunction. Sixteen female rats were randomly divided into control and CCl4 treated groups. The serum levels of tramsaminases, m... see more
Fiaz Alam, Qazi Najumus Saqib, Abdul Waheed
The genus Gaultheria also comprised of species with reported cytotoxic activities. Current research work was carried out to evaluate G. trichophylla crude extract and respective saponins fraction against human colorectal cancer cell line (Caco-2) ba... see more
Charmaine Kahiya, Clemence Zimudzi
Methanol and aqueous root extracts of Indigofera serpentinicola were investigated for their phytochemical, antimicrobial and cytotoxic properties. Phytochemical analysis showed the presence of alkaloids, saponins, tanins, terpenoids, cardiac glycosides, p... see more
Tian-Dan Liu, Ke Yang, Fu-Kui Li
Increasing numbers of children undergo surgery and are exposed to anesthesia that raises concerns regarding the safety of frequently employed anesthetics. Isoflurane, often used in pediatric anesthesia, has been reported to cause neurodegeneration in anim... see more
Qiang Zhang, Yu-Ting Wang, Shi-Mei Jing, Jian-Yong Chang, Jin-Peng Wang
Cancer protective effect of cruciferous vegetables is partly attributed to organic isothiocyanates (ITC) with an N = C = S functional group. Elucidation of the mechanism by which ITCs impart protection against cancer has been the topic of intense research... see more
Jian-Hong Lu, Zhen Shen, Shu-Xin Zhang, Jin-Yu Zhang
The aim of this study was to synthesize novel amide derivatives of bergapten and evaluate their lipid-lowering and triglyceride-lowering activities in mice. Amide derivatives of bergapten were synthesized by using lactone ring opening strategy in DM... see more
Rui-Xia Zhu, Lei Zhao, Yu-Kun Zhang, Peng Luo, Si-Hai Liu, Jin-Guang Wang
Combination therapy has prolonged the survival of patients with small cell lung cancer (SCLC), an aggressive neoplasm characterized by a high rate of metastasis. In the present study the effect of sequential treatment of ursolic acid chlorophenyl triazole... see more
Mahesh Biradi, Kirankumar Hullatti
Premna serratifolia (Syn: Premna integrifolia) is an important medicinal herb known as Agnimantha in Ayurveda and traditionally used for anticancer activity. The objective of present study was to isolate the cytotoxic phytoconstituents from the n-hexane s... see more
Hao Ding, Ben-Zhong Wang, Hua-Qing Zhu, Liu-Yi Dong, Yu-Fang Gu, Yu Zhao
The study was devised to investigate the effect of retinoic acid trifloromethyl chalcone (RAFC) on mammary carcinogenesis in female rats. The data revealed a significant decrease in number of rats with mammary tumor, number of tumors per rat and tumor vol... see more
Nobuhle Mbhele, Fatai O. Balogun, Mutiu I. Kazeem, Tom Ashafa
This study evaluates the antimicrobial, antioxidant and antidiabetic potential of leaf and root extracts of Cephalaria gigantea. The results showed that the extracts inhibited both bacteria and fungi tested at MIC values which ranged from 3.1 to 12.5 mg/m... see more
Khalid Hussain Janbaz, Waseem Hassan, Malik Hassan Mehmood, Anwar Hassan Gilani
The study was tempted to explore the scientific basis for the medicinal use of Adiantum capillus-veneris L. in diarrhea using the in vivo and in vitro assays. The crude extract of dried leaves of A. capillus-veneris exhibited antidiarrheal effect against ... see more
Guo-Min Zhu, Guo-Dong Huang
A series of 1, 3-diaryl-2-propen-1-ones was synthesised in order to obtain a new type of anticancer drug, designed with hybrid features to inhibit colon cancer activated receptor. Based on computational modelling and docking studies, potential inhibitors ... see more
Humaira Gul, Khizar Abbas, Muhammad Imran Qadir
The objective of the study was to evaluate anti-ulcer potential of Mentha longifolia. The rats (four groups) were given orally the vehicle (normal saline, 2 mL/kg) as control group, ethanol extracts of the plant at dose of 100 mg/kg and 200 mg/kg of body ... see more
Saikat Ranjan Paul, Md. Lukman Hakim
The hypoglycemic activity of pet-ether extracts of leaves and methanol extracts of seeds of Manilkara zapota was evaluated in the study. The oral glucose tolerance test was performed in mice treated with 2 mg/kg glucose solution and the blood glucose leve... see more