16 articles in this issue
B. O. Varynskyi,A. G. Kaplaushenko
A. O. Deviatkina,O. M. Svechnikova,S. V. Kolisnyk,N. P. Kobzar,A. F. Vinnyk
The reactivity of substituted 5,7-dichloro-9-hydrazine acridine that exhibit various pharmacological activity by studying acid-base equilibria in the ethanol-water binary solvent (50 mol % ethanol) at 250? using the method of potentiometric titration has ... see more
V. Yu. Anisimov,V. O. Gelmboldt,N. Yu. Bevz,V. A. Georgiyants
Fluorides are the most important treatment and preventive additive in the composition of any form; they prevent development of caries by increasing the resistance of enamel, as well as production of acids by bacteria of dental plaque. At the Odessa Nation... see more
M. Yu. Golik,O. S. Kryskiv,A. M. Komissarenko,O. V. Kolisnyk,K. I. Dudka
Using on-line services and the ChemBioOffice2014 software package the values of the partition coefficients of some N-R-amine derivatives have been calculated. To identify the quantitative relationships and select the optimal algorithm of calculations the ... see more
I. V. Sych,L. O. Perekhoda,Z. G. Ieromina,L. O. Grinevich,N. P. Kobzar,I. V. Drapak
With the aim of obtaining new biologically active substances the synthesis of amides of 5-R-phenylamino-1,3,4-thiadiazole-2-yl-thioacetate acid and 5-phenylamino-1,3,4-thiadiazole-2-yl-thio-1-phenon has been conducted. As initial substances 5-R-phenylamin... see more
N. A. Blyznyuk,Yu. S. Prokopenko,V. A. Georgiyants,V. V. Tsyvunin
In the Ukrainian flora such plants as Forsythia europaea Deg. et Bald, Jasminum officinale L., Berberis thunbergii DC, Weigela hybrida Jaeg., Ligustrum vulgare L., and Corylus avellana L. hold a special place among shrubs. The aim of our research was to a... see more
G. V. Vovk,O. M. Koshovyi,A. M. Komissarenko
The amino acid and monosaccharide composition of a dry extract from Salvia officinalis leaves obtained by complex processing has been studied. The preliminary determination of amino acids and monosaccharides has been performed by paper chromatography. The... see more
A. M. Goy
The introduction of the innovative technological process for industrial production of parenteral dosage forms by the example of Torasemide, solution for injection has been substantiated in the article. The experimental studies for improving the manufactur... see more
T. M. Kovalyova,N. P. Polovko
The present work contains the study of stabilizing properties of Aristoflex AVC polymeric viscosity modifier and stabilizer of the oil/water type emulsion systems. The technological, physicochemical and rheological studies of emulsions on basis of the Ari... see more
O. Yu. Nkachuk,L. I. Vyshnevska,T. M. Zubchenko
The experimental studies conducted allow determining the critical parameters and their effect on the manufacturing process of oil extracts of the composition of the herbal raw material with the hepatoprotective action. The influence of the particle size o... see more
V. A. Georgiyants,V. M. Kushniruk,P. O. Bezugly
The principles of “green chemistry” have been introduced into the procedure of manufacturing synthesis of Amizone. All starting raw materials as solvents have been assessed in accordance with their human toxicity, danger in production, as well as the poss... see more
L. I. Shulga,K. A. Chikhladze,S. M. Rolik,S. O. Povetkin
In order to determine the necessity of creating dental medicinal products the oromucosal dosage forms of the Ukrainian pharmaceutical market have been analysed. Tablet drugs are increasingly used in the treatment of periodontal diseases. Based on the resu... see more
T. V. Diadiun,S. A. Mamedova
Many deaths in consequence of road traffic accidents could be prevented if first aid was given to the victim prior to the arrival of ambulances. This will require the presence of a first aid kit in a vehicle, the contents of which can provide aid in case ... see more
Yu. O. Ovsjanykova,D. V. Levashov,V. M. Kravchenko,V. P. Chernykh,L. A. Shemchuk
Derivatives of 4-oxo-3,4-dihydroquinazoline are known as a promising class of compounds due to their wide spectrum of the pharmacological activity. Taking into account the PASS data for the substituted anthranilamides synthesized, as well as derivatives o... see more
?. ?. Zamorskii,Yu. S. Bukataru,E. L. Lenga,S. V. Kolisnyk,O. O. Altukhov
The results of screening of 2-(benzoyilamino)(1-R-2-oxoindolin-3-ylidene)acetic acid derivatives on the antihypoxic activity are presented in the article. It has been determined that under the conditions of acute hyp?baric hypoxia compounds 4, 14 and 15 h... see more
O. V. Tovchiga,S. Yu. Shtrygol’
The effect of the extract (100 mg/kg and 1 g/kg) and the tincture (1 and 5 ml/kg) of the goutweed (Aegopodium podagraria L.) aerial part on the physical endurance, the level of depression and cognitive functions has been studied using the weight-loaded fo... see more