16 articles in this issue
Yu. Yu. Serdiukova,M. N. Ivashura,T. O. Oleksienko
Simple methods for oxidimetric determination of antibiotic Cefuroxime in the substance and in the powder for solution for injection, which are based on the S-oxidation reaction by potassium hydrogenperoxomonosulphate in a weak acidic medium to S-oxide wit... see more
L. V. Lenchyk
Extracts were obtained from raw materials of cultivated plants from family Rosaceae and pharmacological screening was carried out. It was found that extract of cherry shoots showed diuretic activity higher than the comparator hypothiazide at a dose of 100... see more
I. O. Kolychev,T. A. Krasnikova,O. M. Koshovyi
The qualitative composition and the quantitative content of free and bound amino acids in the alcoholic extract of bilberry leaves have been determined by HPLC using a high performance liquid chromatograph by Agilent Technologies firm (model 1100) equippe... see more
K. Yu. Netyosova,S. S. Kovalenko,O. H. Drushlyak,I. O. Zhuravel,S. M. Kovalenko,E. L. Toryanik
Previously designated a comfortable and effective scheme of 3,7-disubstituted [1,2,4]triazolo[4,3-a]pyrazin-8(7H)-ones synthesis was spread to derivatives of ?-(7-aryl-8-oxo-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrazin-3-yl) alkylcarboxylic acids. Our approac... see more
V. A. Khanin,O. O. Moiseev,A. Ye. Babkina,O. M. Kotenko,A. G. Kotov
Currently, there is a significant amount of drugs created on the basis of the medicinal raw material of the natural origin at the pharmaceutical market of Ukraine. An important source of the medicinal plant raw material for manufacture of cardiotonic drug... see more
K. S. Burdak,T. G. Yarnykh,M. I. Borshchevska,I. B. Yanchuk
Excipients are integral components of almost all medicines. They allow giving the necessary technological properties, which provide accurate dosing, proper strength and disintegration of tablets, to the tabletting mass. However, when developing a medicine... see more
K. N. Toraev,E. M. Bezchasnyuk,T. V. Shyteyeva
Today one of the major problems for the healthcare system of most countries in the world is to optimize pharmacotherapy of diabetes mellitus (DM), which from the category of endemic diseases has turned into a global epidemy in recent decades. In Ukraine t... see more
T. F. Muzika,M. V. Zarichkova,M. V. Chesheva
The article studies the normative legal regulation of distribution and accountability of medicines and medical products (MP) in healthcare institutions and its features that are typical for medical and preventive institutions (MPI). It has been found what... see more
M. M. Kobets
Based on the survey of the population studied sequence variants medicinal purposes in Ukraine. It was found that most of the medicinal purposes is carried out correctly. Thus, 77.5% of respondents said that prescribing precede clinical laboratory tests. D... see more
M. S. Ponomarenko,O. S. Solovyov,S. V. Augunas,Yu. M. Grygoruk
The modern concept of development of pharmaceutical industry of Ukraine requires knowledge of its historical development, including the elements of the optimal use of pharmacy human resources (PHR), implementation and adaptation of its work associated wit... see more
E. V. Bondarev,S. Yu. Shtrygol’,Yu. Yu. Shtrygol’,A. S. Shalamay
The effect of “Glucosamine C-BCPP” dietary supplement on the life time of animals with acute hypothermia in experiments in mice has been determined. It has been found that with intragastric introduction of “Glucosamine C-BCPP” dietary supplement (its comp... see more
I. V. Kireev,S. V. Kolisnyk,N. M. Tryshchuk,K. M. Sytnik
On the model of acute normobaric hypoxic hypoxia with hypercapnia the antihypoxic action of new derivatives of benzilic acid, namely – N-heterylamides of benzilic acid and products of their intramolecular cyclodehydration – thienolactams with five-, six- ... see more
O. Yu. Voskoboynik,G. G. Berest,I. S. Nosulenko,L. M. Antypenko,O. V. Krivoschey,V. M. Shvets,S. I. Kovalenko
It has been found that 6-[(b-dialkylaminoethylthio]-3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones exhibit the antiviral activity against respiratory and the biodefence virus panel (EC50 3.2-36.0 mg/ml) and the influenza type A and B (EC50 1.1-18.0 mg/ml)... see more
M. Yu. Golik,O. S. Kryskiv,K. I. Dudka,O. V. Kolisnyk
To check for conformity of the “drug-likeness” concept in the series of functional derivatives of N-R-amines their physico-chemical parameters have been calculated using the ChemBio3D Ultra 14.0 software; they determine bioavailability according to Lipins... see more
O. S. Sinitsyna,G. V. Zaychenko,I. M. Ryzhenko,Yu. B. Laryanovska
The results of the study morphological structure of the aorta, coronary arteries, heart attack and intramural arteries in female rats who underwent bilateral spaying, and after treatment with their new vaginal gel with extract of hops and the comparative ... see more
G. V. Zaychenko,O. M. Liapunov,O. P. Bezugla
The article describes the pharmacological characteristics of the first selective COX-2 inhibitor – meloxicam, aspects of its mechanism of action, peculiarities of pharmacodynamics and indications, as well as the advantages of the drug compared to the clas... see more