16 articles in this issue
S. V. Vlasov,S. M. Kovalenko,T. P. Osolodchenko,V. P. Chernykh
By alkylation of 3-amino-5-methyl-4-oxo-N-aryl-2-thioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine- 6-carboxamides with substituted benzylchlorides and chloroacetic acid the series of novel derivatives of 3-amino-5-methyl-2-(alkylthio)-4-oxo-N-aryl-3,4-dih... see more
I. S. Nosulenko,O. Yu. Voskoboynik,G. G. Berest,S. I. Kovalenko,O. M. Kamyshnyi,N. M. Polishchuk
In the present paper, 50 new derivatives 2-[8-R1-9-R2-10-R3-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-6-yl)thio]acetic acids have been described. It was shown that alkylation of potassium 8-R1-9-R2-10-R3-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin... see more
Yu. Yu. Labuzova
The presented article is dedicated to the development of new procedure for quantitative voltammetric determination of cefotaxime powder for injection solution preparation in the form of corresponding S-oxide in weak acidic medium using potassium hydrogenp... see more
?. L. Komarytskyy,V. A. Khanin,N. Yu. Bevz,V. A. Georgiyants
Currently a great number of generic drugs have been registered in Ukraine. The advantage of generic drugs is a relatively low cost compared to innovative medicines since creation and registration of gene-rics require less research and, consequently, less ... see more
O. A. Ievtifieieva,K. I. Proskurina,O. V. Ganieva,V. T. Kirdan
Adaptation and validation of the analytical method of photocolorimetric determination of prednisolone using the reaction with phenylhydrazine by the standard method have been carried out in the scientific research laboratory according to standard procedur... see more
Yu. A. Fedchenkova,I. I. Batyuchenko,O. P. Khvorost
Applying the method of nuclear and issue spectrometry there were determined the qualitative structure and the quantitative content of elements in raw materials (leaves, stalks, flowers) of a summer squash (Cucurbita pepo L.), collected in different stages... see more
T. M. Kovalyova,N. P. Polovko
Emulsifying properties of Sepiplus 400 and emulsions on its basis obtained by the method of cold emulsification have been studied. It has been found that the given emulsifier being in the concentration of 1-5% without adding co-emulsifiers and structure-f... see more
V. V. Pul-Luzan,O. P. Strilets,T. V. Martynuk
Based on the results of the microbiological research the necessity of introduction of a preservative into the gel with essential oils developed for treating diseases of the upper respiratory tract has been proven. The microbiological research has been con... see more
L. S. Petrovskaya,O. V. Zhuk,I. I. Baranova
Children, especially infants, have a sensitive and very vulnerable skin. Cosmetics for children supports the protective functions of the skin, making it less susceptible to a variety of stimuli. That is why children from the first days of life need other,... see more
A. A. Kotvitska,O. V. Kononenko
Marketing analysis of the assortment structure of immunobiological medical products (IMP) used for children routine immunization has been described in the article. It has been found that the given group of products is represented at the Ukrainian pharmace... see more
M. V. Zarichkova
The social status of pharmacy specialists (PhS) of the wholesale and retail branch of the pharmaceutical industry of Ukraine and their attitude towards the current social protection (SP) system have been analysed. The possibilities of PhS to gain social p... see more
V. M. Tolochko,D. V. Vakulenko,I. V. Shyshkina
The studies have shown that the manufactured homeopathic medicinal products (MP) existing at the current domestic pharmaceutical market are not appropriate for the individual approach of homeopathic treatment, so the need in their extemporaneous compoundi... see more
V. V. Tsyvunin,S. Yu. Shtrygol’
The results of investigation of the antiepileptic activity of promising herbal anticonvulsants – Fumaria schleicheri (FSDE) and Ocimum basilicum (OBDE) dry extracts – are presented. The herbal remedies were administered intragastrically in the conditional... see more
O. Yu. Koshova
On the model of diabetes mellitus in rats induced by the 18-days subcutaneous administration of dexamethasone in the dose of 0.125 mg/kg the hepatoprotective properties of a new antidiabetic composition based on medicinal plants have been investigated. Th... see more
N. L. Bereznyakova
The most important stage of development of effective and safe new medicines is the methods of preclinical evaluation of their pharmacological activity. Since the existing range of antihypertensive medicines is large enough and the current demands for them... see more
The study of the effect of a new original drug with antioxidant properties – “Elgacin” tablets on cellular component of the immune system of old mice in conditions of the delayed hypersensitivity reaction has been conducted. It has been found that decreas... see more