16 articles in this issue
S. V. Vlasov,V. P. Chernykh,T. P. Osolodchenko
The effective method for the synthesis of ethyl 3-alkyl-5-methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylate derivatives by interaction of diethyl 3-methyl-5-{[(methylsulfanyl)carbothioyl]amino}thiophene-2,4-dicarboxylate with l... see more
S. V. Kholodnyak,K. P. Schabelnyk,G. A. Shernova,T. Yu. Sergeieva,V. V. Ivchuk,O. Yu. Voskoboynik,S. I. Kovalenko,S. D. Trzhetsinskiy,S. I. Okovytyy,S. V. Shishkina
It has been shown that 2-aryl-[1,2,4]triazolo[1,5-c]-quinazolines under the action of nucleophilic agents (hydrazine hydrate, sodium hydroxide, sodium methoxide, hydrochloric acid) undergo hydrolytic cleavage followed by formation of [2-(3-aryl-1H-1,2,4-t... see more
O. S. Golovchenko,V. A. Georgiyants,A. V. Myhal
Pathological conditions of the digestive system are quite common nowadays and rank first among other human diseases. Increasingly, both newly-diagnosed and recurrent cases of stomach ulcers, as well as duodenal ulcers are recorded. Among solid drug dosage... see more
O. P. Strilets
Creation of drugs for treating hypertension, namely the combined tablets based on antihypertensive agents of different pharmacological groups, is very important for domestic pharmaceutical science and practice. According to the results of the previous stu... see more
Yu. V. Iudina
This article presents the results of the study of the process of extraction of biologically active substances from the flowers of Calendula officinalis using pressure enhanced solvent extraction. The Timatic Micro laboratory extractor with the volum... see more
O. Yu. Isayenko
This article describes the physical technology for obtaining surface antigens with protective properties from Bordetella pertussis microbial cells in the absence of additional use of chemical and synthetic substances. The mechanical destruction of c... see more
G. I. Borshchevsky
Currently some success has been achieved when using liposomes in development of new drugs with various actions. Scientists have demonstrated the use of phospholipids as the raw material for production of liposomes. Supercritical fluids are used for ... see more
V. K. Iakovenko,E. A. Khokhlova
On the example of Klimased drug with the purpose of choosing the analytical equipment for quality control of combined drugs of the plant origin the study on major functional and performance characteristics (design qualification) of the equipment use... see more
E. N. Ievtushenko
The article is devoted to peculiarities of risk management in pharmacy. The sources and objects of the risk with their division into internal and external ones have been studied. For each of the risk factors those components of the organization being affe... see more
O. V. Trygubchak
The marketing research of antidiabetic drugs presented at the pharmaceutical market of Ukraine has been conducted. The product range of the group of antidiabetic drugs has been studied according to the ATC classification, manufacturing countries and... see more
O. A. Zdoryk
T. V. Diadiun,I. I. Baranova,A. A. Lytovchenko
To diagnose pregnancy means to ascertain the fact of pregnancy and its duration. Timely and accurate diagnosis of pregnancy and determination of its term are needed to prevent complications, premature birth and prolongation. There are several kinds of tes... see more
E. V. Tolochko
Therapy with medicinal plants and remedies on their basis from time immemorial has been used by mankind to treat a variety of diseases and has not lost its relevance up to now. Today, phytomedicines are used both in the complex therapy (as a complem... see more
S. V. Oleinik
Rhinosinusitis is one of the most common chronic diseases. The studies in recent decades have shown that approximately 10% of rhinosinusitis have an endogenous nature. According to statistics, women more often suffer from rhinosinusitis than men, as well ... see more
O. O. Yakovleva,A. B. Ilchenko
Recently, as evidenced by numerous publications and surveys on the topic, the interest in clarithromycin is not reduced. This drug has a wide range of the antibacterial activity, is able to penetrate into cells and create stable and high tissue concentrat... see more
O. V. Sevryukov,V. A. Volkovoy,O. V. Kolisnyk,K. M. Sytnik
Extension of hypoxic states is a consequence of disorder of cerebral, coronary and peripheral circulation, and it requires further search for substances that can reduce the negative effect of hypoxia on tissues, and increase their resistance to hypoxia. T... see more