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ISSN:    frecuency : 4   format : Electrónica


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Number 4 Year 2014

18 articles in this issue 

S. V. Vlasov,T. P. Osolodchenko,S. M. Kovalenko,V. P. Chernykh

By the reaction of 3-phenyl-6-(a-bromoacetyl)-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione with thioacetamide 5-methyl-6-(2-methyl-1,3-thiazol-4-yl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione was obtained; further the compound was modified by al... see more

Pags. 3 - 7  

A. M. Grozav,A. O. Palamar,V. O. Chornous,I. M. Yaremiy,M. V. Vovk

This study is devoted to development of the optimal conditions for synthesis and the study of some “structure – antioxidant activity” regularities of [(1-arylimidazole-5-yl)methylthio]alkane carboxylic acids, which structural analogues have found an appli... see more

Pags. 8 - 12  

V. M. Bubenchikova,N. V. Popova,Yu. A. Starchak

Hydroxycinnamic acids undoubtedly contribute to the wide range of pharmacological effects of the species of Thyme genus. Rosmarinic acid has antioxidant, hepatoprotective, cardioprotective, nephro-protective, anti-inflammatory, immunomodulatory, anti-alle... see more

Pags. 13 - 16  

O. V. Kryvanych,N. Yu. Bevz,V. A. Georgiyants

The work is devoted to development of the method for quantitative determination of phenylephrine hydrochloride in the combined nasal drops Gripocitron Rinis. Combination of phenylephrine hydrochloride possessing the vasoconstrictor action with dimetindene... see more

Pags. 17 - 21  

S. G. Musienko,V. S. Kyslychenko

The study of the chemical composition of the bay laurel raw material has shown that the plant raw material contains such groups of biologically active substances (BAS) as carbohydrates, fatty and amino acids, phenolic compounds revealing a wide spectrum o... see more

Pags. 22 - 24  

O. A. Yevtifieieva,K. I. Proskurina

The validation characteristics of the spectrophotometric quantitative determination of paracetamol in tablets by specific absorbance according to the British Pharmacopoeia (BPh) have been evaluated. The results of paracetamol content of 83.59% and 84.39% ... see more

Pags. 25 - 31  

O. A. Ruban,Yu. S. Masliy

A medicated chewing gum (MCG) is a new alternative solid dosage form for oral application, which is used for the delivery of a great number of active pharmaceutical ingredients. Monographs for this dosage form are introduced in the SPhU, European Pharmaco... see more

Pags. 32 - 34  

N. A. Gerbina

At the Department of Industrial Technology of Drugs suppositories for the treatment of degenerative and inflammatory diseases of the rectum have been developed; the active substance with the reparative activity – diacamph is included in their composition.... see more

Pags. 35 - 38  

Mustafa Alhussein,A. V. Martynov

The results of the design and selection of compositions of antimicrobial ointments containing gentamicin as the main active substance and succinyl gallotannin as an antiresistant component. The concentration of the latter was 0.001%, had no direct antimic... see more

Pags. 39 - 42  

O. S. Shpychak,O. I. Tikhonov

The aim of this work is to substantiate the qualitative composition and quantitative content of excipients; it will allow to provide optimal properties of the mass for capsulation when producing “Apised” capsules – a new original medicine developed on the... see more

Pags. 43 - 48  

V. K. Iakovenko

Identification and assessment of risks arising in the process of manufacture of extraction herbal medicines have been performed. The object of research was the technological process of manufacture of multicomponent tinctures and liquid extracts. Risk anal... see more

Pags. 49 - 52  

V. V. Malyi

The article is devoted to substantiation of the theoretical aspects of management decision, its modern methods and adaptation of classical theories to pharmaceutical management. The efficiency of enterprises depends on the level of the enterprise manageme... see more

Pags. 53 - 58  

M. M. Kobets,Yu. M. Kobets,O. V. Filiptsova,O. S. Solovyov

The analysis and generalization of the provisions of normative legal acts (NLA) regulating prescription and OTC drugs circulation in Ukraine have been conducted. The causes of violations in dispensing drugs by prescription are the problem of the healthcar... see more

Pags. 59 - 63  

O. A. Zdoryk

To meet the needs of patients for treatment of a number of diseases compounding preparations are often used. The aim of our study was to determine the possibility of introduction of the international experience of forming the quality assurance system for ... see more

Pags. 64 - 68  

A. M. Sheyhali,N. M. Kononenko

The aim of the work was to study acute toxicity, the irritating and allergic effects of a new combined cream “Dermalipoin” consisting of a-lipoic acid, urea, olive oil, tea tree oil, PEG-400. It has been found that the LD50 of the cream with intragastric ... see more

Pags. 69 - 71  

A. A. Goncharova,I. I. Baranova,T. P. Osolodchenko

Microbiological stability is an important requirement to the medicines developed. In order to prevent microbial contamination of medicines it is necessary to use effective antimicrobial preservatives or active substances with a high preservative effect. T... see more

Pags. 72 - 75  

M. V. Rybalkin,N. I. Filimonova,O. P. Strilets,L. S. Strelnikov

It is known that the use of drugs, which are capable to stimulate a protective immune response against candidal infection, i.e. immunobiological drugs stimulating protective functions, is a promising direction in the fight against candidiasis. The aim of ... see more

Pags. 76 - 78  

Ya. S. Kolisnyk,T. V. Upyr,O. M. Koshoviy,S. Yu. Shtrygol’,A. M. Kovaleva

The chemical composition and pharmacological activity of the dry extract based on the herbal tea composed of black horehound (Ballota nigra) herb, white nettle (Lamium album) herb, wormwood (Artemisiae absinthii) herb in equal amounts have been studied. A... see more

Pags. 79 - 82