16 articles in this issue
Leila Pourtalebi Jahromi ,Soliman Mohammadi-Samani ,Reza Heidari ,Amir Azadi
Purpose: Although it passes through blood-brain barrier (BBB) very poorly, methotrexate (MTX) is an important therapeutic in the treatment of many central nervous system malignancies. Accordingly, intranasal (IN) administration accompanied with a muco-adh... see more
Ce Dong ,Xing Ming ,Zhanying Ye ,Pengfei Wang ,Lin Wang ,Zheng Li ,Baogen Pan
Purpose To investigate the role of ICA II in subarachnoid hemorrhage (SAH)- related chronic hydrocephalus. Methods A two hemorrhage injection model of SAH was created in Sprague Dawley rats (6-8 weeks). A total of 125 rats were randomly assigned into fiv... see more
Yunzi Ma ,Zhongbao Yue ,Boyu Zhang ,Min Yang ,Haiyan Lao ,Weihua Lai ,Yingtong Zeng ,Shaorui Chen ,Peiqing Liu
Prostaglandin E2 (PGE2), one of the arachidonic acid metabolites synthetized from arachidonic acid through cyclooxygenase (COX) catalysis, demonstrates multiple physiological and pathological actions through different subtypes of EP receptors. PURPOSE: Th... see more
Svetlana A. Ivanova ,Valentina M. Alifirova ,Ivan V. Pozhidaev ,Maxim B. Freidin ,Irina A. Zhukova ,Diana Z. Osmanova ,Natalia G. Zhukova ,Yulia A. Mironova ,Vladimir V. Tiguntsev ,Olga Yu. Fedorenko ,Nikolay A. Bokhan ,Bob Wilffert ,Anton J.M. Loonen
Purpose. Parkinson's disease (PD), a common neurodegenerative disorder, is usually treated with Levodopa (L-DOPA). The use of this drug, however, is severely limited by the development of side effects of the motor system: Levodopa-induced dyskinesia (LID)... see more
Daniel Pecoraro Demarque ,Rui Milton Patrício Silva ,Leandro Figueiredo Santos ,Andréia Machado Leopoldino ,Enilza Maria Espreafico ,Norberto Peporine Lopes
The purpose of this contribution is to evaluate the cytotoxicity and apoptosis inducing ability of structurally diverse anthraquinones to establish a relationship between structure and toxicity. Besides the wide spread use of anthraquinones in pharmacolog... see more
Amélie Marsot
Providing a safe and efficacious drug therapy for large and often heterogeneous populations is a challenging objective in clinical drug development and routine clinical practice. It has been known for years that the optimum dose required for many therapeu... see more
Waleed Mohammed-Saeid ,Rania Soudy ,Richa Tikoo ,Kamaljit Kaur ,Ronald E Verrall ,Ildiko Badea
Purpose Achieving successful gene therapy requires delivery of a gene vector specifically to the targeted tissue with efficient expression and a good safety profile. The objective of this work was to develop, characterize and determine if a novel gemini s... see more
Vanessa Cristina Meira de Amorim ,Markley Silva Oliveira Júnior ,Eduardo Muniz Santana Bastos ,Victor Diogenes Amaral da Silva ,Silvia Lima Costa
Purpose: Flavonoids are a group of secondary metabolites of the polyphenols class present in several plant species. Among them, the biflavonoid agathisflavone is of interest since it bears several biological effects that include: antiviral, antitumoral, a... see more
Zhuo Ma ,Lifang Guo ,Xiangli Cui ,He Liu ,Lihong Liu
Objectives: Endostar (recombinant human endostatin (rh-endostatin)), a 20-kDa proteolytic fragment of collagen XVIII, was approved for the treatment of non–small cell lung cancer (NSCLC). Recently, several studies have evaluated the efficacy of rh-endosta... see more
Nayab Khalid ,Muhammad Sarfraz ,Mosab Arafat ,Muhammad Akhtar ,Raimar Löbenberg ,Nisar Ur Rehman
PURPOSE: The purpose of this study was to investigate the ability of a self-nano-emulsifying drug delivery system (SNEDDS) to enhance the oral bioavailability of a BCS class IV drug, etoposide (VP-16). METHOD: A series of SNEDDS formulations with VP-16 we... see more
Deniz Ozdin ,Naveen Sharma ,Jorge Lujan-Zilbermann ,Philippe Colucci ,Isadore Kanfer ,Murray P. Ducharme
Purpose: As per the US FDA guidance issued on June 2, 1995, the establishment of bioequivalence for topical dermatologic corticosteroids is based on comparing the pharmacodynamic (PD) effects of Test and Reference products at the dose duration correspondi... see more
Marie Claire Van Hout
Purpose: Lyme disease has become an increasingly important global public health concern. Method: A narrative review was conducted and designed to present a broad perspective on Lyme disease, and describe its history and development in terms of clinical ca... see more
Ruizhou Wang ,Lu Han ,Qixia Gao ,Dan Chen ,Yun Wang ,Xia Zhang ,Xin Yu ,Yueming Zhang ,Zhiyong Li ,Changcai Bai
Many clinical diseases are accompanied by the symptoms of pain, and the degree of pain is closely related to the patients’ suffering. Therefore, effectively relieving pain has become one of the vital concerns of clinical treatment and analgesic drug resea... see more
Ranjeet Prasad Dash ,R. Jayachandra Babu ,Nuggehally R Srinivas
Number of drugs with different mechanisms of actions is undergoing clinical trials for non-alcoholic steatohepatitis (NASH). Given the complexity of the disease with respect to pathophysiology in the liver and associated changes in the renal function, it ... see more
Ana Rita Castro ,Sara Oliveira Silva ,Sandra Clara Soares
Cardiovascular diseases (CVDs) are responsible for a high mortality rate worldwide. One of the most common causes of CVDs is vascular inflammation associated to atherosclerosis. Inflammatory biomarkers are used to assist the detection of CVDs and monitor ... see more
Magdalena Izdebska ,Mariola Herbet ,Monika Gawronska-Grzywacz ,Iwona Piatkowska-Chmiel ,Agnieszka Korga ,Marcin Sysa ,Magdalena Iwan ,Dorota Natorska-Chomicka ,Ewa Poleszak ,Andrzej Wróbel ,Slawomir Mandziuk ,Jaroslaw Dudka
Purpose: The aim of this study was to evaluate the effect of resveratrol on de novo lipogenesis in HepG2 cells caused by high glucose concentrations. Increased lipogenesis in the liver is the main reason for the development of nonalcoholic fatty liver dis... see more