11 articles in this issue
Kahina Daheb ,Jean-Philippe Lecours ,Mark L. Lipman ,Patrice Hildgen ,Julie J. Roy
Purpose. In order to update our data on drug dialyzability using the high-permeability dialysis membranes, atenolol elimination by an in vitro dialysis model was compared to that observed in six patients during high-permeability hemodialysis (HD), and the... see more
Kahina Daheb ,Mark L. Lipman ,Patrice Hildgen ,Julie J Roy
Purpose. The purpose of this study was to develop an artificial neural network (ANN) model to predict drug removal during dialysis based on drug properties and dialysis conditions. Nine antihypertensive drugs were chosen as model for this study. Methods. ... see more
Laszlo Endrenyi ,Laszlo Tothfalusi
The US Food and Drug Administration (FDA) has recently suggested that the bioequivalence (BE) for products of drugs with narrow therapeutic indices (NTI) be assessed by the approach of reference-scaled average BE (SABE). Subsequently, in December, 2012, t... see more
Nagendra Chemuturi ,Jaime A Yanez
The eye is a very complex sensory organ consisting of numerous structures to coordinate the function of sight. It has a series of physical and chemical barriers to help maintain its homeostasis, and mediate environmental exposures. Transporters in the eye... see more
Yusuke Tadayasu ,Akiko Sarashina ,Yasuhiro Tsuda ,Shinji Tatami ,Christian Friedrich ,Silke Retlich ,Alexander Staab ,Mikihisa Takano
[Objectives] Linagliptin is a novel, highly selective and long acting DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM). Linagliptin exhibits non-linear pharmacokinetics (PK) due to saturable binding to plasma and tissue DPP-4. The aim ... see more
Hajime Maruyama ,Jiro Ogura ,Asuka Fujikawa ,Yusuke Terada ,Takashi Tsujimoto ,Takahiro Koizumi ,Kaori Kuwayama ,Masaki Kobayashi ,Hiroaki Yamaguchi ,Ken Iseki
Purpose. Intestinal ischemia-reperfusion (I/R) causes gut dysfunction and promotes multi-organ failure. The liver and kidney can be affected by multi-organ failure after intestinal I/R. Organic anion transporting polypeptides (OATPs) and organic anion tra... see more
Rong Chen ,Jie Xue ,Meilin Xie
PURPOSE. Our previous studies have demonstrated that osthole, an active constituent isolated from the fruit of Cnidium monnieri (L.) Cusson, can prevent isoprenaline-induced myocardial fibrosis in mice, but the underlying mechanism is still unclear. METH... see more
Juliana de Almeida Pachioni ,Juliana Gallottini Magalhães ,Elys Juliane Cardoso Lima ,Luciana de Moura Bueno ,Joyce Ferreira Barbosa ,Matheus Malta de Sá ,Carlota Oliveira Rangel-Yagui
PURPOSE: Since when alkylphospholipds (ALPs) were discovered and, even further after miltefosine’s approval for the treatment of cutaneous metastasis of breast cancer and leishmaniasis, their activity against many other diseases have been extensively stud... see more
Prasanta Kumar Ghosh ,Anjali Gaba
Data generated through systematic investigation, carried out on the evaluation of phyto-extracts on wound healing research during the last 20 years have been compiled. About 450 plant species having wound healing properties have been identified. The prese... see more
Sam Harirforoosh ,Waheed Asghar ,Fakhreddin Jamali
Non-steroidal anti-inflammatory drugs (NSAIDs) are used chronically to reduce pain and inflammation in patients with arthritic conditions, and also acutely as analgesics by many patients. Both therapeutic and adverse effects of NSAIDs are due to inhibitio... see more
Nouf M AL-Rasheed ,Hala A Attia ,Raessa A Mohamed ,Nawal M Al-Rasheed ,Maha A Al-Amin
Purpose: Accumulating evidences suggest a critical role of trace metal dyshemostasis in oxidative stress and cardiac dysfunction after myocardial infarction (MI). This study investigated the cardioprotective effects of selenium yeast (Se), chromium picoli... see more