13 articles in this issue
Boon Hooi Tan ,Yan Pan ,Amelia Nathania Dong ,Chin Eng Ong
In vitro and in silico models of drug metabolism are utilized regularly in the drug research and development as tools for assessing pharmacokinetic variability and drug-drug interaction risk. The use of in vitro and in silico predictive approaches offers ... see more
Negar Motayagheni ,Sheshanna Phan ,Ala Nozari ,Anthony Atala
Efforts to develop a treatment for bupivacaine cardiotoxicity led to the discovery that Intralipid, a popular brand of intravenous lipid emulsion, could be used not only as an effective treatment for anesthetic-induced cardiac arrest, but also as a means ... see more
Agnes Victoria Klein ,Jian Wang ,Brian G. Feagan ,Mark Omoto
On May 12, 2017, various issues and challenges associated with biologics were discussed during a session of the annual joint conference of Canadian Society for Pharmaceutical Sciences and Canadian Chapter of Controlled Release Society at Hyatt Regency Hot... see more
Zvetanka Dobreva Zhivkova
Purpose. Binding of drugs to plasma proteins is a common physiological occurrence which may have a profound effect on both pharmacokinetics and pharmacodynamics. The early prediction of plasma protein binding (PPB) of new drug candidates is an important s... see more
Charlotte Heemskerk ,Evelien Woldman ,Marieke Pereboom ,Ruud van der Hoeven ,Aukje Mantel-Teeuwisse ,Claudia van Gemeren ,Matthijs Lambertus Becker
Purpose. Ciprofloxacin may prolong the QT interval and increase the risk of Torsade de Pointes (TdP). Intravenous administration of ciprofloxacin in patients with additional risks may elevate the risk of QTc interval prolongation. We prospectively assesse... see more
Semira Abdi Beshir ,Lok Bin Yap ,Szyuin Sim ,Kok Han Chee ,Yoke Lin Lo
Purpose: To assess the predicted rate and the factors associated with bleeding events among patients with non-valvular atrial fibrillation (NVAF) receiving dabigatran therapy. Methods: This retrospective cohort study includes adult patients of two tertiar... see more
Kelu Hou ,Hui Yang ,Zhikang Ye ,Ying Wang ,Lihong Liu ,Xiangli Cui
Objectives: We performed this systematic review and meta-analysis to confirm whether patients benefit more from pharmacist-led anticoagulation management than other models. Methods: We searched PubMed, Embase, Cochrane Library and reference lists of yield... see more
Nor Haizan Ibrahim ,Khalidah Maruan ,Hasryn Azzuar Mohd Khairy ,Yet Hoi Hong ,Ahmad Fauzi Dali ,Chin Fen Neoh
Purpose: To systematically review studies on cost-effectiveness of implementing Antimicrobial stewardship programmes (ASP) in the hospital setting. Methods: A systematic literature search was performed using electronic databases, such as EMBASE, PubMed/Me... see more
Dat T Tran ,Ilke Akpinar ,Richard Fedorak ,Egon Jonsson ,John Mackey ,Lawrence Richer ,Philip Jacobs
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Cigdem Ozen ,Meltem Ceylan Unlusoy ,Nazanin Aliary ,Mehmet Ozturk ,Oya Bozdag Dundar
Purpose: A new series of thiazolyl-2,4-thiazolidinedione / rhodanine compounds T1-T23 was synthesized and tested for their anticancer activities. Hepatocellular carcinoma cell lines were chosen due to their strong drug resistance to test the new compounds... see more
Noormohamad Mansoori ,Masoumeh Douraghi ,Ali Akbar Rajabloo ,Masoomeh Taziki ,Mehdi Yaseri ,Farzam Vaziri
Purpose: The incidence of tuberculosis (TB) in Golestan province of Iran has been ranked 10th among countries of World Health Organization (WHO) Eastern Mediterranean Region. The province is residence of ethnically heterogeneous groups. However, there are... see more
Jieyun Cao ,Michael Ng ,Melanie A Felmlee
Purpose: Monocarboxylate transporters (MCTs) are involved in the transport of monocarboxylates such as ketone bodies, lactate, and pharmaceutical agents. CD147 functions as an ancillary protein for MCT1 and MCT4 for plasma membrane trafficking. Sex differ... see more
Negar Firouzabadi ,Anna Nazariat ,Kamiar Zomorrodian
PURPOSE: Autism, a neuropsychiatric illness, is a complex ailment of mainly indefinite cause. Although precise pathophysiological mechanism is unclear but the role of genetics is undeniable therefore pharmacogenetics may assist to a better management of s... see more