10 articles in this issue
wang xin ,yang hui ,zhang xiaodong ,cui xiangli ,wang shihui ,liu lihong
Objectives: Valganciclovir 900 mg/day is approved for cytomegalovirus (CMV) prophylaxis, but 450 mg/day is seems also effective. We systematically reviewed the efficacy and safety of low-dose versus high-dose valganciclovir prophylaxis in renal transplant... see more
Farideh Amirrad ,Emira Bousoik ,Kiumars Shamloo ,Hassan Al-Shiyab ,Viet-Huong V. Nguyen ,Hamidreza Montazeri Aliabadi
Alzheimer’s disease (AD) is an irreversible neurodegenerative disease characterized by a progressive decline in cognition and memory, leading to significant impairment in daily activities and ultimately death. It is the most common cause of dementia, the ... see more
Amélie Marsot ,Romain Guilhaumou ,Jean Philippe Azulay ,Olivier Blin
Background: Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease. Although levodopa remains the single effective agent in the management of Parkinson’s disease, the accurate determination of this optimal dosag... see more
Yufei Chen ,Wei Li ,Guqi Wang ,Frank J Burczynski
PURPOSE: To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. METHODS: Rat hepatoma cells (CRL-1548) were treated with a fatty acid (FA) mixture consisti... see more
Paramjeet Kaur ,Xiaojian Jiang ,Ethan Stier
The US FDA’s rule on “Requirements for Submission of Bioequivalence Data” requiring submission of all bioequivalence (BE) studies conducted on the same formulation of the drug product submitted for approval was published in Federal Register in January 200... see more
Erik Wollmer ,Sandra Klein
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available. The objective of the... see more
Sonia Gupta ,Vijay Prabha
The rising population with grave ramifications for the future is a fundamental issue, demanding for newer and better contraceptive modalities. Also, in order to achieve the contraceptive purpose, the choice of the most suitable delivery system is of unque... see more
Fei Chen ,Lingjing Jin ,Zhiyu Nie
We aimed to comprehensively analyse the safety and efficiency of rotigotine for treating Parkinson’s disease (PD). We conducted systematic literature searches of Cochrane library, PubMed and Embase databases up to April 2016, with ‘Rotigotine’, ‘Parkinson... see more
Hamed Gilzad-Kohan ,Shabnam Sani ,Mehdi Boroujerdi
Purpose. Efflux and influx proteins play a major role in chemo-resistance by affecting the net cellular uptake of anti-cancer drugs. Hence, alteration of the efflux and influx protein expression may result in variations of chemotherapeutics uptake and con... see more
Mosab Arafat ,Cathrin Kirchhoefer ,Momir Mikov ,Muhammad Sarfraz ,Raimar Löbenberg
PURPOSE: Liposomes have been studied as a colloidal carrier in drug delivery systems, especially for oral administration. However, their low structural integrity in the gut is still a major shortcoming. Membrane disruptive effects of physiological bile sa... see more