11 articles in this issue
Jean-Pierre Gregoire ,Paul Poirier ,Norma Pérez ,Éric Demers ,Jocelyne Moisan
Purpose. Ticagrelor is recommended following an acute coronary syndrome if used appropriately. Its use has not yet been well described in the context of ambulatory clinical practice. The objective of this study was to assess the proportion of ticagrelor n... see more
Azadeh Serri ,Arash Mahboubi ,Afshin Zarghi ,Hamid Reza Moghimi
Purpose: The antibacterial activity of some antibiotics is specific to either Gram-positive or Gram-negative bacteria. There are different mechanisms behind such insensitivities like inability of antibiotics to permeate through some bacterial membranes, ... see more
Carley E Johnson ,Jody K Takemoto
The American Diabetic Association standards of medical care for diabetic patients recommends moderate intensity exercise to help manage diabetes; however, this recommendation may be unmanageable for patients who have become inactive or unable to reach thi... see more
Alfredo Garcia Arieta ,Craig Simon ,Gustavo Mendes Lima Santos ,Iván Omar Calderón Lojero ,Zulema Rodríguez Martínez ,Clare Rodrigues ,Sang Aeh Park ,Ji Myoung Kim ,Ryosuke Kuribayashi ,Yusuke Okada ,Arno Nolting ,Chantal Pfäffli ,Wen-Yi Hung ,Christopher Crane ,April C Braddy ,Joy van Oudtshoorn ,Diego Gutierrez Triana ,Mitch Clarke
The acceptance of foreign comparator products is the most limiting factor for the development and regulatory assessment of generic medicines marketed globally. Bioequivalence studies have to be repeated with the local comparator products of each jurisdict... see more
Zahra Moradpour ,Leila Barghi
Epidermal growth factor receptors (EGFRs) have potential to be considered as therapeutic target for cancer treatment especially in cancer patients with overexpression of EGFR. Cetuximab as a first monoclonal antibody and Imatinib as the first small molecu... see more
Clara C Chan ,C. Lisa Prokopich
Dry eye disease (DED) is a common inflammatory disorder of the ocular surface. Millions of people are affected by DED worldwide. Lifitegrast is a novel drug designed to inhibit DED-associated ocular inflammation. Four clinical trials have shown that lifit... see more
Ying Wang ,Zhikang Ye ,Lihong Liu ,Xiangli Cui
Purpose. Studies provided conflicting results on whether antidepressant use increased the risk of venous thromboembolism (VTE). Our aim was to examine the association between antidepressant use and the risk of VTE. Methods. Pubmed, Embase, and the Cochran... see more
Masahiro Iwaki ,Toshiro Niwa ,Hiroyuki Tanaka ,Atsushi Kawase ,Hiroshi Komura
Hepatic clearance (CLh) of carvedilol (CAR), which is eliminated via stereoselective metabolism by the CYP2D subfamily of cytochromes P450 (CYPs), was predicted using liver microsomes and hepatocytes from Sprague-Dawley (SD) rats and CYP2D-deficient Dark ... see more
Haley N. Ilcewicz ,Erin K. Hennessey ,Carmen B. Smith
Purpose: Inpatient hyperglycemia is associated with poor outcomes. Existing research assessing inpatient hyperglycemia protocols has shown improvements in average blood glucose levels with inconsistent results regarding rates of hypoglycemia and hyperglyc... see more
Natalia Kordulewska ,Anna Cieslinska ,Ewa Fiedorowicz ,Beata Jarmolowska ,Elzbieta Kostyra
Purpose: Fexofenadine (FXF) is the active metabolite of terfenadine with selective peripheral H1 receptor antagonist activity. FXF is a third-generation antihistamine, non-sedating, rapid and very long acting used in symptoms associated with allergic dise... see more
Won Seok Bang ,Ye Ran Hwang ,Zhengri Li ,Inchul Lee ,Hee Eun Kang
Purpose: Preliminary study results have shown that rats with non-alcoholic fatty liver disease (NAFLD) induced by 1% orotic acid-containing diet have decreased hepatic CYP2D activity. This study aims to evaluate the possible pharmacokinetic changes in NAF... see more