8 articles in this issue
Liang Li ,Tao Yi ,Christopher Wai-kei Lam
PURPOSE: This study investigated influences of concentration and combination of excipients, commonly used in self-emulsifying drug delivery systems (SEDDS), on inhibition of human efflux transporter ABCC2 (MRP2). METHODS: Ten commonly used excipients of S... see more
Yahya Khazaie ,Farid Abedin Dorkoosh ,Luis Novo ,Ethlinn van Gaal ,Afshin Fassihi ,Seyedeh Zohreh Mirahmadi-Zareh ,Mohammad Hossein Nasr Esfahani ,Cornelus F. van Nostrum ,Wim E. Hennink
Purpose. The aim of this study was to investigate the in vitro gene delivery efficiency of poly[N-(2-aminoethyl)ethylene-imine](PAEEI), a polymer with a linear Polyethyleneimine (LPEI) backbone and with aminoethyl side groups that has two protonatable nit... see more
Toshihiro Sato ,Hiroaki Yamaguchi ,Takuma Kogawa ,Takaaki Abe ,Nariyasu Mano
PURPOSE. Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. Th... see more
Radu M Nanau ,Lawrence E Cohen ,Manuela G Neuman
Background: Biological therapies using anti-tumor necrosis factor (TNF)-a agents have an important impact in the treatment of inflammatory bowel disease, rheumatoid arthritis, psoriasis, and other inflammatory conditions. However, a significant number of ... see more
Mariana Celestina Frojuello Costa Bernstorff Damião ,Kerly Fernanda Mesquita Pasqualoto ,Michelle Carneiro Polli ,Roberto Parise Filho
Purpose. Prodrug design is a strategy that can be used to adjust physicochemical properties of drugs in order to overcome pharmacokinetic problems, such as poor oral bioavailability. However, Lipinskís and Veber´s rules predict whether compounds will have... see more
Beatriz San Román ,Sara Gómez ,Juan M. Irache ,Socorro Espuelas
Purpose: The objective of this work was to evaluate the effect in the immune response produced by CpG oligodeoxynucleotides (ODN) co-encapsulated with the antigen ovalbumin (OVA) within poly(lactic-co-glycolic) acid (PLGA) 502 and 752 microparticles (MP).... see more
Ozra Tabatabaei-Malazy ,Shekoufeh Nikfar ,Bagher Larijani ,Mohammad Abdollahi
Purpose.There are controversial data regarding the beneficial effects of ascorbic acid (AA) supplementation in type 2 diabetes mellitus (T2DM). In this systematic review, we aimed to criticize the current relevant data from both observational and randomiz... see more
Yan Wang ,Sheng Tu ,Dana Steffen ,May Xiong
PURPOSE. The formulation of histone deacetylase inhibitors (HDACi) is challenging due to poor water solubility and rapid elimination of drugs in vivo. This study investigated the effects of complexing iron (Fe3+) to the HDACi suberoylanilide hydroxamic ac... see more