19 articles in this issue
Basil D Roufogalis ,Arthur D Conigrave ,Emanuel E Strehler
This Special Issue of the Journal of Pharmacy and Pharmaceutical Sciences arises from an inaugural conference on “Mechanism-Based Natural Product Development” held at Whistler Mountain, Canada on September 21-22, 2012.The aim of the conference was to brin... see more
Basil D Roufogalis ,Arthur D Conigrave
Mechanism-Based Development of Natural Products in Human Health
Antonio Villalobo ,Irene García-Palmero ,Silviya R. Stateva ,Karim Jellali
Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we will ... see more
Emanuel E Strehler
Plasma membrane Ca2+ ATPases (PMCAs) are highly regulated transporters responsible for Ca2+ extrusion from all eukaryotic cells. Different PMCA isoforms are implicated in various tasks of Ca2+ regulation including bulk Ca2+ transport and localized Ca2+ si... see more
Ji-Ming Ye ,Stanley M.H.
This review discusses issues largely from the biological point of view about the targeted approaches for the use of natural products for the discovery of anti-diabetic drugs in collaboration with medicinal chemists and computer-aided drug design. A major ... see more
Tamer M A Mohamed ,Simon A Zakeri ,Florence Baudoin ,Markus Wolf ,Delvac Oceandy ,Elizabeth J Cartwright ,Sheraz Gul ,Ludwig Neyses
Purpose. ATPases, which constitute a major category of ion transporters in the human body, have a variety of significant biological and pathological roles. However, the lack of high throughput assays for ATPases has significantly limited drug discovery in... see more
Pauline Yu-Hsiu Huang ,Philippa Kohnke ,Larissa Belov ,Giles Best ,Stephen Peter Mulligan ,Richard Ian Christopherson
Purpose. Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, some patients may survive for many years, while 20-30% of patients progress and may die within several years. Currently, there is not a single procedure that enables accurate prognos... see more
Mary Bebawy ,Ariane Roseblade ,Frederick Luk ,Tristan Rawling ,Alison Ung ,Georges E. R. Grau
Intercellular communication is essential to maintain vital physiological activities and to regulate the organism’s phenotype. There are a number of ways in which cells communicate with one another. This can occur via autocrine signaling, endocrine signali... see more
Con Stough ,Andrew Scholey ,Vanessa Cropley ,Keith Wesnes ,Andrea Zangara ,Matthew Pase ,Karen Savage ,Karen Nolidin ,Luke Downey
Bacopa monniera (EBm), an Indian aquatic herb, has been used in traditional Ayurvedic medicine for centuries for indications related to memory and inflammation. More recently specific extracts of EBm have emerged that have been subjected to rigorous in vi... see more
Bradley S Simpson ,David J Claudie ,Nicholas M Smith ,Ross A McKinnon ,Susan J Semple
With one of the oldest surviving cultures in the world, Australian Aboriginal people have developed immense knowledge about the diverse Australian flora. Western scientific investigation of some Australian Aboriginal medicinal plants has demonstrated inte... see more
Casey Sayre ,Neal Davies
Purpose. Research indicating potentially beneficial bioactivity of flavonoids has produced a market and demand for natural health products and dietary supplements containing flavonoids. Implementation of the Canadian natural health product (NHP) regulatio... see more
Mohammad H. Gilzad-Kohan ,Kamaljit Kaur ,Fakhreddin Jamali
Purpose. We have previously shown favorable in vitro gut permeability for three novel di-peptide esters of glucosamine (GlcN) likely facilitated by the peptide transporter 1 (PepT1). Herein, we report the development of a novel assay for the determination... see more
Nuggehally R Srinivas
Cranberry juice is a popular beverage with many health benefits. It has anthocyanins to supplement dietary needs. Based on in vitro evidence cranberry juice is an inhibitor of CYP enzymes and at higher amounts as potent as ketoconazole (CYP3A) and flucona... see more
Yiming Li ,Van H Tran ,Nooshin Koolaji ,Colin Duke ,Basil D Roufogalis
PURPOSE. The aim of this study was to investigate the mechanism of (S)-[6]-gingerol in promoting glucose uptake in L6 skeletal muscle cells. METHODS. The effect of (S)-[6]-gingerol on glucose uptake in L6 myotubes was examined using 2-[1,2-3H]-deoxy-D-glu... see more
Sravan Mandadi ,Peter Hong ,Arjun Sunny Dhoopar ,Patrick Whelan
Pediatric spinal cord injury (SCI) often leads to increased nociceptive input resulting in aberrant motor output like tremor and spasticity. Acute plasticity within spinal pain and motor networks following pediatric SCI may result in long-term sensorimoto... see more
Nadeem Ahmad Siddique ,Mohd Mujeeb ,Sayeed Ahmad ,Bibhu P. Panda ,Mohd Makhmoor
Purpose. The intention of the proposed work is to study the presence of the aflatoxins B1, B2, G1 and G2 in medicinal plants, namely Mucuna pruriens, Delphinium denudatum and Portulaca oleraceae. Methodology. The aflatoxins were extracted, purified by imm... see more
Qiong Gu ,Xin Yan ,Jun Xu
Purpose. The Human Genome Project is producing a new biological ‘periodic table’, which defines all genes for making macromolecules (proteins, DNA, RNA, etc) and the relations between genes and their biological functions. We now need to consider whether t... see more
Srinivas Nammi ,Basil D Roufogalis
Purpose: Fatty liver disease, a hepatic manifestation of metabolic syndrome, is one of the major causes of chronic liver diseases. Epidemiological studies suggest that regular light-to-moderate ethanol consumption lowers the risk of developing metabolic d... see more
Saeed Samarghandian ,Abasalt Borji ,Mohammad Bagher Delkhosh ,Fariborz Samini
Purpose. Clinical research has confirmed the efficacy of several plant extracts in the modulation of oxidative stress associated with diabetes mellitus. Findings indicate that safranal has antioxidant properties. The aim of the present study was the evalu... see more