14 articles in this issue
Behzad Sharif Makhmalzadeh ,Ommoleila Molavi ,Mohammad Reza Vakili ,Hai-Feng Zhang ,Amir Solimani ,Hoda Soleymani Abyaneh ,Raimar Loebenberg ,Raymond Lai ,Afsaneh Lavasanifar
Purpose: Silibinin, is a natural compound, which has shown anticancer activity in various malignancies. In this study, we evaluated the anticancer effects of silibinin in B16-F10 melanoma cells and developed a novel thermoresponsive hydrogel for local del... see more
Bahar Darsazan ,Alireza Shafaati ,Afshin Zarghi ,Seyed Alireza Mortazavi
Purpose: Adefovir is an antiviral drug that exhibits high hydrophilic properties and negligible bioavailability (less than 12%). It is only applied in the form of the ester prodrug adefovir dipivoxil (ADV). The oral bioavailability of ADV is limited (32% ... see more
Hila Yousefi ,Mohammas Abdollahi
Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. ... see more
Seyyedeh Elaheh Mousavi ,Pegah Saberi ,Naeemeh Ghasemkhani ,Nahid Fakhraei ,Rezvan Mokhtari ,Ahmad Reza Dehpour
PURPOSE: Licofelone, a dual cyclooxygenase/5-lipoxygenase inhibitor, possesses antioxidant, antiapoptotic, neuroprotective, and anti-inflammatory properties. The aim of the present study was to investigate the effect of licofelone on lipopolysaccharide (L... see more
Takashi Satoh ,Ayaka Igarashi ,Misaki Tanno ,Koki Yamada ,Natsuko Takahashi-Suzuki ,Kazuhiro Watanabe
Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs). The aim of the present study was to evalu... see more
WenHua Li ,SongQi Guo ,Shu Wang ,Xin Sun ,ZhuQin Li ,XinYong Sun ,YanMing Sun ,LanFeng Wang ,Wei Pan
Purpose. This study aimed to explore the effects of ticagrelor (a P2Y12 receptor inhibitor) on interleukin (IL)-17 and myeloperoxidase (MPO) expression in coronary thrombus as well as on the coronary blood flow in ST-segment elevation myocardial infarctio... see more
Hui-Qi See ,Jin-Ning Chan ,Shu-Jin Ling ,Shang-Cheng Gan ,Chee-Onn Leong ,Chun-Wai Mai
Big data is anticipated to have large implications in clinical pharmacy, in view of its potential in enhancing precision medicine and to avoid medication error. However, it is equally debatable since such a powerful tool may also disrupt the need of pharm... see more
Boyu Li ,Ying Wang ,Zhikang Ye ,Hui Yang ,Xiangli Cui ,Zhenjun Wang ,Lihong Liu
PURPOSE: Non-alcoholic fatty liver disease (NAFLD) affects about 75% of patients with type 2 diabetes mellitus (T2DM). We conducted a meta-analysis to determine the effect of canagliflozin on fatty liver indexes in T2DM patients. METHODS: A literature sea... see more
Daniel Valente Neves ,Carolina Pinto Vieira ,Adriana Rocha ,Vera Lucia Lanchote
PURPOSE: Ceftriaxone elimination occurs through breast cancer resistance transporter (BCRP) and multidrug resistance-associated protein 2 (MRP-2) which are expressed on the canalicular membrane of hepatocytes. Eltrombopag, a thrombopoetin receptor agonist... see more
Masashi Kawami ,Tadashi Shimonakamura ,Ryoko Yumoto ,Mikihisa Takano
Purpose. Alveolar clearance of proteins, such as albumin, plays an essential role in recovery from lung injuries. Albumin is known to be oxidized by reactive oxygen species (ROS), leading to generation of advanced oxidation protein products (AOPP)-albumin... see more
Matina Symeonidi ,Irene Panagiotou ,Eleni Tsilika ,Anna Roumeliotou ,Antonis Galanos ,Kyriaki Mystakidou
Purpose: Pain is prevalent in cancer patients, appearing to be moderate to severe in more than one third of them. Despite the fact that fentanyl is widely used with effective analgesic results, some patients do not correspond to treatment, resulting in op... see more
Bárbara Athayde Vaz Galvão da Silva ,Ana Marisa Chudzinski-Tavassi ,Kerly Fernanda Mesquita Pasqualoto
Background: The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated wit... see more
John SG Wells ,Michael Bergin ,Marie-Claire Van Hout ,Pádraig McGuinness ,Jaco De Pleissisc ,Eileen Rich ,Siphokazi Dada ,Richard Wells ,Martina Ann Gooney
Purpose. Codeine containing medicines can carry a number of health risks associated with the increase in reported misuse and dependence, however they are still readily available over the counter (OTC) in many countries. The aim of this novel study was to ... see more
Katsuhiko Matsui ,Saeko Kanai ,Manami Ikuta ,Saki Horikawa
Background: The skin of patients with atopic dermatitis (AD) is superficially colonized by Staphylococcus aureus. We have previously found that percutaneous permeation of peptidoglycan (PEG) from S. aureus increases the number of mast cells in the dermis,... see more