7 articles in this issue
Saghi Sepehri ,Horacio Perez Sanchez ,Afshin Fassihi
Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to the convenient methods that exist for their synthesis an... see more
Manuela G Neuman ,Radu M Nanau ,Loida Oruña-Sanchez ,Gabriel Coto
Background. We developed an experimental model of ethanol-induced dermatotoxicity and hepatocytoxicity using normal human keratinocytes and normal human hepatocytes that preserve inducible cytochrome p450 activities. The original work was described in sev... see more
Roger K Verbeeck ,Sophie De Niet ,Sonia Lebrun ,Mickael Tremege ,Tim W. Rennie ,Monte Coffiner ,Bruno Streel ,Bernard Cahay
Purpose: The therapeutic equivalence of multiple registered fenofibrate formulations, several of which are suprabioavailable and therefore marketed at lower dosage strengths than their reference products, is based on the results of bioequivalence studies.... see more
Wimonchat Tangamornsuksan ,Ornrat Lohitnavy ,Chuenjid Kongkaew ,Nathorn Chaiyakunapruk ,Brad Reisfeld ,Norman Charles Scholfield ,Manupat Lohitnavy
OBJECTIVES: This study aimed to systematically review and quantitatively synthesize the association between HLA-B*5701 and abacavir-induced hypersensitivity reaction (ABC-HSR). METHODS: We searched for studies that investigated the association between HLA... see more
Rania A.H. Ishak
Gastric retentive drug delivery provides a promising technology exhibiting an extended gastric residence and a drug release independent of patient related variables. It is usually useful in improving local gastric treatment as well as overcoming drug-rela... see more
Brian Chapron ,Linda Risler ,Brian Phillips ,Carol Collins ,Kenneth Thummel ,Danny Shen
Purpose Telaprevir inhibits CYP3A resulting in drug-drug interactions (DDI) of unprecedented magnitude. We investigated the mechanisms by which telaprevir inhibits the oxidation of midazolam and tacrolimus in human liver microsomes (HLM). Methods We per... see more
Mohsen Sharifi Klishadi ,Farideh Zarei ,Seyyed Hassan Hejazian ,Ali Moradi ,Mahdieh Hemati ,Fatemeh Safari
PURPOSE: Sirtuin-3 (SIRT3) deacetylase protects the heart against oxidative stress via survival factors upregulation. Clinical and experimental studies have demonstrated that activation of systemic and local renin-angiotensin system (RAS) is implicated in... see more