10 articles in this issue
Muhammad Umair ,Ibrahim Javed ,Mubashar Rehman ,Asadullah Madni ,Aqeel Javeed ,Aamir Ghafoor ,Muhammad Ashraf
Nanotechnology has opened a new horizon of research in various fields including applied physics, chemistry, electronics, optics, robotics, biotechnology and medicine. In the biomedical field, nanomaterials have shown remarkable potential as theranostic ag... see more
Wei Jiang ,Juan-juan Yang ,Lei Cao ,Xue Xiao ,Xiao-lian Shi ,Yong-xiao Cao
Purpose: Absolute bioavailability (F) is calculated as the ratio of the area under the plasma drug concentration-time curve (AUC) between extravascular administration and intravenous injection. However, as distribution of a drug after intravenous administ... see more
Takashi Satoh ,Haruka Fujisawa ,Ami Nakamura ,Natsuko Takahashi ,Kazuhiro Watanabe
PURPOSE: Green tea is a traditional beverage that has been enjoyed by the Japanese to this day. Recently, there has been an increase in the consumption of green tea beverage having high concentrations of catechins, such as (-)-epigallocatechin-3-O-gallate... see more
Ioana Todor ,Adina Popa ,Maria Neag ,Dana Muntean ,Corina Bocsan ,Anca Buzoianu ,Laurian Vlase ,Ana-Maria Gheldiu ,Corina Briciu
Purpose: To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. Methods: An open-label, non-randomized, two-period,... see more
Meiyan Yang ,Wei Gong ,Yuli Wang ,Li Shan ,Ying Li ,Chunsheng Gao
The formulation development for poorly soluble drugs still remains a challenge. Supersaturating drug delivery systems (SDDS) or drug delivery systems based on supersaturating provide a promising way to improve the oral bioavailability of poorly water-solu... see more
Nenad Petrovic
Since early seventies of the twentieth century, through seminal work of Judah Folkman, angiogenesis, the process of new blood vessel sprouting from the existing vasculature, was recognized as a necessary part of wound healing, development of placenta, tis... see more
Helal H. Alsulimani ,Jonghan Kim ,Shabnam N. Sani
Purpose. To develop a quantitative pharmacokinetic model to characterize the disposition of methotrexate (MTX) at tumor site in tumor-bearing mice and to predict MTX concentrations in the human tumor. Methods. The plasma profiles of MTX were obtained from... see more
Hashem Alsaab ,Sindhu Prabha Bonam ,Dherya Bahl ,Pallabita Chowdhury ,Kenneth Alexander ,Sai HS. Boddu
Organogels have emerged as an alternative carrier for small and macromolecules via transdermal, oral, rectal and ophthalmic routes. Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle fo... see more
Hui Yang ,Xiangli Cui ,Zhuo Ma ,Lihong Liu
A better dosing strategy can improve clinical outcomes for patients. We systematically reviewed the literatures to determine whether any clinical benefits exist for piperacillin/tazobactam by extended or continuous infusion. Methods - A search of PubMed, ... see more
Maki Matsuhama ,Tomoko Takishita ,Ryosuke Kuribayashi ,Kazunori Takagi ,Rika Wakao ,Kenichi Mikami
Purpose. A gap analysis survey of international practices for Active Substance Master Files (ASMFs)/Drug Master Files (DMFs) of human use was conducted as a project of the ASMF/DMF working group of the International Generic Drug Regulators Pilot (IGDRP) t... see more