13 articles in this issue
Negar Firouzabadi ,Roshanak Raeesi ,Kamiar Zomorrodian ,Ehsan Bahramali ,Ilnaz Yavarian
Purpose: The adrenoceptor family, as one of the main contributors in regulating the noradrenergic system, has been studied in involvement of depression and its treatment. A functional polymorphism of G1165C on beta adrenoceptor (ßAR) enhances post recepto... see more
Caroline Brais ,Josiane Larochelle ,Marie-Hélène Turgeon ,Lucie Blais ,Paul Farand ,Sylvie Perreault ,Geneviève Letemplier ,Marie-France Beauchesne
PURPOSE: Several factors have been associated with the prescription of direct oral anticoagulants (DOAC) over warfarin such as younger age, fewer concomitant medications, and lower CHADS2 or bleeding scores. The primary objective of this study was to iden... see more
yang hui ,cui xiangli ,wang xin ,qiu shuang ,liu lihong
Objectives:We conducted a systematic review and meta-analysis to compare the clinical outcomes of patients after liver transplantation accepting antiviral prophylaxis (AP) or preemptive therapy (PT) for preventing cytomegalovirus (CMV) disease. Methods: A... see more
Bhargavi Latha Athukuri ,Prasad Neerati
Purpose: Domperidone is a commonly used antiemetic drug. The oral bioavailability of domperidone is very low due to its rapid first pass metabolism in the intestine and liver. Piperine, the main alkaloid present in black pepper has been reported to show i... see more
Katsuhiko Matsui ,Kanta Tachioka ,Kei Onodera ,Reiko Ikeda
Background: Patients with atopic dermatitis (AD) have superficial skin colonization by Staphylococcus aureus and an increased number of T helper type 2 (Th2) cells in their peripheral blood. Our previous study showed that josamycin, a macrolide antibiotic... see more
Hussein Nori Rubaiy
The birth and discovery of electrophysiological science took place in the 18th century laying the path for our understanding of nerve membrane ionic currents. The pore-forming proteins, ion channels, are involved and play critical roles in very importan... see more
Ana-Maria Gheldiu ,Laurian Vlase ,Adina Popa ,Corina Briciu ,Dana Muntean ,Corina Bocsan ,Anca Buzoianu ,Marcela Achim ,Ioan Tomuta ,Ioana Todor ,Maria Neag
Purpose: To investigate whether fluvoxamine coadministration can influence the pharmacokinetic properties of nebivolol and its active hydroxylated metabolite (4-OH-nebivolol) and to assess the consequences of this potential pharmacokinetic interaction upo... see more
Seyyed Majid Eslami ,Shekoufeh Nikfar ,Maryam Ghasemi ,Mohammad Abdollahi
Proprotein convertase subtilisin-kexin type 9 (PCSK9) is a member of regulatory serine proteases which is mostly expressed in liver. In the physiological condition, LDL-C binds to LDL receptors (LDLRs) and via endocytosis, LDLRs are degraded. PCSK9 binds ... see more
Richard Tester ,Farage H Al-Ghazzewi
Glucomannans play a much broader role in human health then providing dietary fibre. They are biologically active molecules and can when added to the body imitate innate molecules found in different organs including surface carbohydrates on cells. This rev... see more
Lyghia Maria Araújo Meirelles ,Fernanda Nervo Raffin
There has been a growing trend in recent years for the development of hybrid materials, called composites, based on clay and polymers, whose innovative properties render them attractive for drug release. The objective of this manuscript was to conduct a r... see more
Zvetanka Dobreva Zhivkova
Purpose. The success of a new drug candidate is determined not only by its efficacy and safety, but also by proper pharmacokinetic behavior. The early prediction of pharmacokinetic parameters could save time and resources and accelerate drug development p... see more
Feridoun Parnia ,Javad Yazdani ,Vahid Javaherzadeh ,Solmaz Maleki Dizaj
PURPOSE: Nanomaterials are suitable candidates for coating of titanium based (Ti-based) dental implants due to their unique properties. The objective of this article is to summarize the application of nanoparticles as Ti-based implant coating materials in... see more
Qing Wang ,Si Chen ,Yan-Gang Zhou ,Ping Xu ,Yi-Ping Liu ,Hua-Lin Cai ,Hong Chen ,Zheng Luo ,Hoan Linh Banh
PURPOSE: This study investigated the association between vancomycin blood brain barrier penetration and clinical response in patients with postsurgical meningitis. METHODS: Adult patients with postsurgical meningitis were recruited. Eligible patients rece... see more