11 articles in this issue
Hugo Almeida ,Maria Helena Amaral ,Paulo Lobão ,Ana C Silva ,José Manuel Sousa Loboa
The unique properties and characteristics of ocular tissues and the whole set of defence mechanisms of the ocular globe make the instillation of ocular drugs into a difficult task with a low rate of therapeutic response. One of the challenges for the new ... see more
Teresa W Tam ,Rui Liu ,Ammar Saleem ,John Thor Arnason ,Anthony Krantis ,Brian C Foster
PURPOSE: Thirty-five commercially available Camellia sinensis (black and green) and herbal leisure teas and an assortment of Traditional Chinese medicinal teas were randomly selected and examined for their potential to inhibit the drug metabolizing enzyme... see more
Márcio Rodrigues ,Gilberto Alves ,Joana Francisco ,Ana Fortuna ,Amílcar Falcão
Purpose - Carica papaya has been traditionally used worldwide in folk medicine to treat a wide range of ailments in humans, including the management of obesity and digestive disorders. However, scientific information about its potential to interact with c... see more
Hiroyuki Tanaka ,Tatsuhiko Wada ,Yoko Takayama ,Keisuke Matsumoto ,Koichiro Atsuda ,Mitsutoshi Satoh
Purpose. Antiretroviral therapy is now available for HIV-infected patients, and so-called highly active antiretroviral therapy (HAART) now makes it possible to strongly suppress viral proliferation and restore immunity. However, the development of new dru... see more
Radu M Nanau ,Manuela G Neuman
Purpose. Inflammatory and rheumatic arthritis remain leading causes of disability worldwide. The arthritis therapeutic area commands the largest market for the prescription of biological and non-steroidal anti-inflammatory drugs (NSAID). Yet biotechnology... see more
Fan Yang ,Rachita K Sumbria ,Dong Xue ,Chuanhui Yu ,Dan He ,Shuo Liu ,Annlia Paganini-Hill ,Mark Fisher
PURPOSE: The first genomewide association study indicated that variations in the phosphodiesterase 4D (PDE4D) gene confer risk for ischemic stroke. However, inconsistencies among the studies designed to replicate the findings indicated the need for furthe... see more
Sergey Pustylnikov ,Divya Sagar ,Pooja Jain ,Zafar K Khan
Dextran, the a-1,6-linked glucose polymer widely used in biology and medicine, promises new applications. Linear dextran applied as a blood plasma substitute demonstrates a high rate of biocompatibility. Dextran is present in foods, drugs, and vaccines an... see more
Emmanuel O. Aiyere ,Jay Silverberg ,Safina Ali ,Jayson L. Parker
Purpose. To determine the risk of clinical trial failure for drugs developed for type-2 diabetes. Methods. Drugs were investigated by reviewing phase I to phase III studies that were conducted between 1998 and February 2013. The clinical trial success ra... see more
Asadullah Madni ,Muhammad Sarfraz ,Mubashar Rehman ,Mahmood Ahmad ,Naveed Akhtar ,Saeed Ahmad ,Nayab Tahir ,Shakeel Ijaz ,Raida Al-Kassas ,Raimar Löbenberg
Liposomes are lipid based vesicular systems that offer novel platform for versatile drug delivery to target cell. Liposomes were first reported by Bangham and his co-workers in 1964 (1). Since then, liposomes have undergone extensive research with the pri... see more
Amal Kaddoumi ,Loqman A. Mohamed
PURPOSE. The knowledge of hepatic disposition kinetics of tacrine, a first cholinesterase inhibitor was approved by FDA for the treatment of Alzheimer’s disease (AD), would help to understand its hepatotoxicity, its therapeutic effect, and improve the man... see more
Wayne Goh ,Inna Sleptsova-Freidrich ,Nenad Petrovic
PURPOSE: Triple negative breast cancers (estrogen, progesterone and human epidermal growth factor 2 (HER2) receptor-negative) are among the most aggressive forms of cancers with limited treatment options. Doxorubicin is one of the agents found in many of ... see more