11 articles in this issue
Duangchit Panomvana ,Tharathorn Traiyawong ,Somchai Towanabut
Purpose: To determine the effects of CYP3A5 polymorphisms on carbamazepine (CBZ) pharmacokinetic parameters when CBZ is used either as monotherapy or co-administered with phenytoin (PHT), phenobarbital (PB) or valproic acid (VPA). Methods: Retrospective d... see more
Harpreet K Chhina ,Vidula M Bhole ,Charles Goldsmith ,Wendy Hall ,Janusz Kaczorowski ,Diane Lacaille
PURPOSE. To synthesize current knowledge about the effectiveness and the magnitude of the effect, of Academic Detailing (AD), as a stand-alone intervention, at modifying drug prescription behavior of Family Physicians (FPs) in primary care settings. METHO... see more
Hitesh B Vaidya ,Abeer A Ahmed ,Ramesh K Goyal ,Sukhinder K Cheema
Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the ma... see more
Jiukuan Hao ,Ulrich Bickel
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue. The present... see more
Takayuki Furuishi ,Yukiko Kato ,Toshiro Fukami ,Toyofumi Suzuki ,Tomohiro Endo ,Hiromasa Nagase ,Haruhisa Ueda ,Kazuo Tomono
Purpose. Lomerizine dihydrochloride (LOM) is a Ca2+ channel blocker used as an antimigraine drug, which is currently administered orally in Japan. We therefore investigated the effect of terpenes in propylene glycol (PG) solvent on the percutaneous absorp... see more
Suja Abraham ,Minumaria Shaju
In the past twenty years, thirteen new antiepileptic drugs (AEDs) have been introduced, each differing in their efficacy spectrum, mechanism of action, pharmacokinetics, safety and tolerability profiles. These newer AEDs symbolize a welcoming future in th... see more
Ali Shayanfar ,Hamed Ghavimi ,Hamed Hamishekar ,Abolghasem Jouyban
Purpose: Atorvastatin calcium (ATC) is classified as class II (low solubility and high permeability) compound according to the biopharmaceutical classification system. The amorphous form of ATC possesses higher solubility, dissolution rate, and bioavailab... see more
Simin Dashti-Khavidaki ,Azadeh Moghaddas ,Behrooz Heydari ,Hossein Khalili ,Mahboob lessan-Pezeshki ,Mahbooh Lessan-Pezeshki
Drug-induced nephrotoxicity (DIN) accounts for up to 60% of hospital acquired acute kidney injury with considerable morbidity and mortality. Several efforts have been made to reduce drug-induced nephrotoxicity; however, DIN remains a matter of concern. St... see more
Advaita Ganguly ,Ravindra B. Malabadi ,Dipankar Das ,Mavanur R. Suresh ,Hoon H Sunwoo
Purpose. To highlight the expression and purification of the recombinant dengue virus type-1 antigen exploiting the codon optimized full length envelope for increased yield in E. coli. Methods. A 6x His tag was inserted at the C terminus to facilitate pur... see more
Katarina Nikolic ,Slavica Filipic ,Adam Smolinski ,Roman Kaliszan ,Danica Agbaba
PURPOSE. Rate of brain penetration (logPS), brain/plasma equilibration rate (logPS-brain), and extent of blood-brain barrier permeation (logBB) of 29 a-adrenergic and imidazoline-receptors ligands were examined in Quantitative-Structure-Property Relations... see more
Mi Hye Kwon ,Cheol Jung Lee ,Yong Yeon Cho ,Hee Eun Kang
Purpose. To evaluate the possible changes in CYP2E1 expression and activity in hyperlipidemia (HL), we evaluated the pharmacokinetics of chlorzoxazone (CZX) as a CYP2E1 probe in rats with HL induced by poloxamer 407 (HL rats). Methods. The pharmacokinetic... see more